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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
NLRP5
Full Name:
NACHT, LRR and PYD domains-containing protein 5
Alias:
Mater protein homolog
Type:
Mass (Da):
134342
Number AA:
1200
UniProt ID:
P59047
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S46
L
F
P
Q
N
L
S
S
Q
P
C
I
K
M
E
Site 2
S57
I
K
M
E
G
D
K
S
L
T
F
S
S
Y
G
Site 3
T59
M
E
G
D
K
S
L
T
F
S
S
Y
G
L
Q
Site 4
S61
G
D
K
S
L
T
F
S
S
Y
G
L
Q
W
C
Site 5
Y70
Y
G
L
Q
W
C
L
Y
E
L
D
K
E
E
F
Site 6
T79
L
D
K
E
E
F
Q
T
F
K
E
L
L
K
K
Site 7
S88
K
E
L
L
K
K
K
S
S
E
S
T
T
C
S
Site 8
S89
E
L
L
K
K
K
S
S
E
S
T
T
C
S
I
Site 9
S91
L
K
K
K
S
S
E
S
T
T
C
S
I
P
Q
Site 10
T92
K
K
K
S
S
E
S
T
T
C
S
I
P
Q
F
Site 11
T93
K
K
S
S
E
S
T
T
C
S
I
P
Q
F
E
Site 12
S95
S
S
E
S
T
T
C
S
I
P
Q
F
E
I
E
Site 13
S139
N
M
N
L
R
T
L
S
E
K
A
R
D
D
M
Site 14
S150
R
D
D
M
K
R
H
S
P
E
D
P
E
A
T
Site 15
T159
E
D
P
E
A
T
M
T
D
Q
G
P
S
K
E
Site 16
S179
S
Q
A
V
Q
Q
D
S
A
T
A
A
E
T
K
Site 17
S191
E
T
K
E
Q
E
I
S
Q
A
M
E
Q
E
G
Site 18
S210
E
T
E
E
Q
E
I
S
Q
A
M
E
Q
E
G
Site 19
T223
E
G
A
T
A
A
E
T
E
E
Q
G
H
G
G
Site 20
Y235
H
G
G
D
T
W
D
Y
K
S
H
V
M
T
K
Site 21
T241
D
Y
K
S
H
V
M
T
K
F
A
E
E
E
D
Site 22
S252
E
E
E
D
V
R
R
S
F
E
N
T
A
A
D
Site 23
T256
V
R
R
S
F
E
N
T
A
A
D
W
P
E
M
Site 24
S272
T
L
A
G
A
F
D
S
D
R
W
G
F
R
P
Site 25
T281
R
W
G
F
R
P
R
T
V
V
L
H
G
K
S
Site 26
S293
G
K
S
G
I
G
K
S
A
L
A
R
R
I
V
Site 27
S331
M
Q
R
K
K
E
S
S
V
T
E
F
I
S
R
Site 28
T333
R
K
K
E
S
S
V
T
E
F
I
S
R
E
W
Site 29
S337
S
S
V
T
E
F
I
S
R
E
W
P
D
S
Q
Site 30
S343
I
S
R
E
W
P
D
S
Q
A
P
V
T
E
I
Site 31
T348
P
D
S
Q
A
P
V
T
E
I
M
S
R
P
E
Site 32
S369
D
G
F
D
D
L
G
S
V
L
N
N
D
T
K
Site 33
T389
A
E
K
Q
P
P
F
T
L
I
R
S
L
L
R
Site 34
S419
V
G
T
E
K
L
K
S
E
V
V
S
P
R
Y
Site 35
S423
K
L
K
S
E
V
V
S
P
R
Y
L
L
V
R
Site 36
T452
G
I
G
E
H
Q
K
T
Q
G
L
R
A
I
M
Site 37
S490
L
Q
D
V
V
G
E
S
V
A
P
F
N
Q
T
Site 38
S544
E
G
V
W
N
R
K
S
V
F
D
G
D
D
L
Site 39
Y579
P
D
S
H
C
E
E
Y
Y
T
F
F
H
L
S
Site 40
Y580
D
S
H
C
E
E
Y
Y
T
F
F
H
L
S
L
Site 41
Y611
E
P
A
L
C
P
L
Y
V
E
K
T
K
R
S
Site 42
T615
C
P
L
Y
V
E
K
T
K
R
S
M
E
L
K
Site 43
S642
R
F
L
F
G
L
V
S
E
D
V
R
R
P
L
Site 44
S670
Q
K
L
L
H
W
V
S
L
L
G
Q
Q
P
N
Site 45
T680
G
Q
Q
P
N
A
T
T
P
G
D
T
L
D
A
Site 46
Y732
F
C
L
Q
H
C
P
Y
L
R
K
I
R
V
D
Site 47
T764
P
L
W
M
R
D
K
T
L
I
E
E
Q
W
E
Site 48
T779
D
F
C
S
M
L
G
T
H
P
H
L
R
Q
L
Site 49
S791
R
Q
L
D
L
G
S
S
I
L
T
E
R
A
M
Site 50
T794
D
L
G
S
S
I
L
T
E
R
A
M
K
T
L
Site 51
T800
L
T
E
R
A
M
K
T
L
C
A
K
L
R
H
Site 52
S841
M
A
N
R
N
L
R
S
L
N
L
G
G
T
H
Site 53
T891
L
K
I
S
Q
I
L
T
T
S
P
S
L
K
S
Site 54
S898
T
T
S
P
S
L
K
S
L
S
L
A
G
N
K
Site 55
S900
S
P
S
L
K
S
L
S
L
A
G
N
K
V
T
Site 56
S915
D
Q
G
V
M
P
L
S
D
A
L
R
V
S
Q
Site 57
S945
T
G
C
Q
S
L
A
S
A
L
V
S
N
R
S
Site 58
T954
L
V
S
N
R
S
L
T
H
L
C
L
S
N
N
Site 59
S959
S
L
T
H
L
C
L
S
N
N
S
L
G
N
E
Site 60
S962
H
L
C
L
S
N
N
S
L
G
N
E
G
V
N
Site 61
S981
S
M
R
L
P
H
C
S
L
Q
R
L
M
L
N
Site 62
S1014
N
S
W
L
T
H
L
S
L
S
M
N
P
V
E
Site 63
S1016
W
L
T
H
L
S
L
S
M
N
P
V
E
D
N
Site 64
S1036
C
E
V
M
R
E
P
S
C
H
L
Q
D
L
E
Site 65
S1062
E
S
L
S
C
V
I
S
R
S
R
H
L
K
S
Site 66
S1064
L
S
C
V
I
S
R
S
R
H
L
K
S
L
D
Site 67
S1069
S
R
S
R
H
L
K
S
L
D
L
T
D
N
A
Site 68
T1073
H
L
K
S
L
D
L
T
D
N
A
L
G
D
G
Site 69
S1094
E
G
L
K
Q
K
N
S
V
L
A
R
L
G
L
Site 70
T1125
L
S
C
N
R
H
L
T
S
L
N
L
V
Q
N
Site 71
S1126
S
C
N
R
H
L
T
S
L
N
L
V
Q
N
N
Site 72
S1135
N
L
V
Q
N
N
F
S
P
K
G
M
M
K
L
Site 73
Y1163
I
G
L
W
K
W
Q
Y
P
V
Q
I
R
K
L
Site 74
S1186
P
R
V
V
I
D
G
S
W
H
S
F
D
E
D
Site 75
S1189
V
I
D
G
S
W
H
S
F
D
E
D
D
R
Y
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation