KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
ZNF445
Full Name:
Zinc finger protein 445
Alias:
Zinc finger protein 168;Zinc finger protein with KRAB and SCAN domains 15
Type:
Mass (Da):
118963
Number AA:
1031
UniProt ID:
P59923
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y10
P
G
R
W
H
A
A
Y
P
A
Q
A
Q
S
S
Site 2
S16
A
Y
P
A
Q
A
Q
S
S
R
E
R
G
R
L
Site 3
T25
R
E
R
G
R
L
Q
T
V
K
K
E
E
E
D
Site 4
S34
K
K
E
E
E
D
E
S
Y
T
P
V
Q
A
A
Site 5
Y35
K
E
E
E
D
E
S
Y
T
P
V
Q
A
A
R
Site 6
T36
E
E
E
D
E
S
Y
T
P
V
Q
A
A
R
P
Site 7
T45
V
Q
A
A
R
P
Q
T
L
N
R
P
G
Q
E
Site 8
Y63
Q
L
F
R
Q
L
R
Y
H
E
S
S
G
P
L
Site 9
S66
R
Q
L
R
Y
H
E
S
S
G
P
L
E
T
L
Site 10
S67
Q
L
R
Y
H
E
S
S
G
P
L
E
T
L
S
Site 11
T72
E
S
S
G
P
L
E
T
L
S
R
L
R
E
L
Site 12
S74
S
G
P
L
E
T
L
S
R
L
R
E
L
C
R
Site 13
S122
V
Q
L
H
N
P
E
S
G
E
E
A
V
A
L
Site 14
T140
L
Q
R
D
L
D
G
T
S
W
R
D
P
G
P
Site 15
S141
Q
R
D
L
D
G
T
S
W
R
D
P
G
P
A
Site 16
S150
R
D
P
G
P
A
Q
S
P
D
V
H
W
M
G
Site 17
S168
L
R
S
A
Q
I
W
S
L
A
S
P
L
R
S
Site 18
S171
A
Q
I
W
S
L
A
S
P
L
R
S
S
S
A
Site 19
S175
S
L
A
S
P
L
R
S
S
S
A
L
G
D
H
Site 20
S176
L
A
S
P
L
R
S
S
S
A
L
G
D
H
L
Site 21
S177
A
S
P
L
R
S
S
S
A
L
G
D
H
L
E
Site 22
Y187
G
D
H
L
E
P
P
Y
E
I
E
A
R
D
F
Site 23
S199
R
D
F
L
A
G
Q
S
D
T
P
A
A
Q
M
Site 24
T201
F
L
A
G
Q
S
D
T
P
A
A
Q
M
P
A
Site 25
T221
G
C
P
G
D
Q
V
T
P
T
R
S
L
T
A
Site 26
S225
D
Q
V
T
P
T
R
S
L
T
A
Q
L
Q
E
Site 27
T227
V
T
P
T
R
S
L
T
A
Q
L
Q
E
T
M
Site 28
T235
A
Q
L
Q
E
T
M
T
F
K
D
V
E
V
T
Site 29
Y259
D
S
A
Q
R
N
L
Y
R
D
V
M
L
E
N
Site 30
Y267
R
D
V
M
L
E
N
Y
R
N
M
A
S
L
V
Site 31
S272
E
N
Y
R
N
M
A
S
L
V
G
P
F
T
K
Site 32
S316
P
T
G
D
D
L
Q
S
K
T
N
K
F
I
L
Site 33
T318
G
D
D
L
Q
S
K
T
N
K
F
I
L
N
Q
Site 34
T333
E
P
L
E
E
A
E
T
L
A
V
S
S
G
C
Site 35
S346
G
C
P
A
T
S
V
S
E
G
I
G
L
R
E
Site 36
S354
E
G
I
G
L
R
E
S
F
Q
Q
K
S
R
Q
Site 37
S381
K
K
E
E
T
N
F
S
H
R
T
G
K
D
S
Site 38
S388
S
H
R
T
G
K
D
S
E
V
S
G
S
N
S
Site 39
S391
T
G
K
D
S
E
V
S
G
S
N
S
L
D
L
Site 40
S393
K
D
S
E
V
S
G
S
N
S
L
D
L
K
H
Site 41
S395
S
E
V
S
G
S
N
S
L
D
L
K
H
V
T
Site 42
T402
S
L
D
L
K
H
V
T
Y
L
R
V
S
G
R
Site 43
Y403
L
D
L
K
H
V
T
Y
L
R
V
S
G
R
K
Site 44
S407
H
V
T
Y
L
R
V
S
G
R
K
E
S
L
K
Site 45
S412
R
V
S
G
R
K
E
S
L
K
H
G
C
G
K
Site 46
S424
C
G
K
H
F
R
M
S
S
H
H
Y
D
Y
K
Site 47
Y428
F
R
M
S
S
H
H
Y
D
Y
K
K
Y
G
K
Site 48
Y430
M
S
S
H
H
Y
D
Y
K
K
Y
G
K
G
L
Site 49
Y433
H
H
Y
D
Y
K
K
Y
G
K
G
L
R
H
M
Site 50
S452
S
L
H
Q
R
I
H
S
G
L
K
G
N
K
K
Site 51
S467
D
V
C
G
K
D
F
S
L
S
S
H
H
Q
R
Site 52
S469
C
G
K
D
F
S
L
S
S
H
H
Q
R
G
Q
Site 53
S470
G
K
D
F
S
L
S
S
H
H
Q
R
G
Q
S
Site 54
S477
S
H
H
Q
R
G
Q
S
L
H
T
V
G
V
S
Site 55
T480
Q
R
G
Q
S
L
H
T
V
G
V
S
F
K
C
Site 56
T493
K
C
S
D
C
G
R
T
F
S
H
S
S
H
L
Site 57
S495
S
D
C
G
R
T
F
S
H
S
S
H
L
A
Y
Site 58
Y502
S
H
S
S
H
L
A
Y
H
Q
R
L
H
T
Q
Site 59
T508
A
Y
H
Q
R
L
H
T
Q
E
K
A
F
K
C
Site 60
S526
G
K
A
F
R
W
S
S
N
C
A
R
H
E
K
Site 61
T536
A
R
H
E
K
I
H
T
G
V
K
P
Y
K
C
Site 62
S554
E
K
A
F
R
R
L
S
A
Y
R
L
H
R
E
Site 63
Y556
A
F
R
R
L
S
A
Y
R
L
H
R
E
T
H
Site 64
T562
A
Y
R
L
H
R
E
T
H
A
K
K
K
F
L
Site 65
Y574
K
F
L
E
L
N
Q
Y
R
A
A
L
T
Y
S
Site 66
T579
N
Q
Y
R
A
A
L
T
Y
S
S
G
F
D
H
Site 67
Y580
Q
Y
R
A
A
L
T
Y
S
S
G
F
D
H
H
Site 68
S592
D
H
H
L
G
D
Q
S
G
E
K
L
F
D
C
Site 69
S610
R
K
S
F
H
C
K
S
Y
V
L
E
H
Q
R
Site 70
Y611
K
S
F
H
C
K
S
Y
V
L
E
H
Q
R
I
Site 71
T620
L
E
H
Q
R
I
H
T
Q
E
K
P
Y
K
C
Site 72
Y653
L
H
E
E
E
K
F
Y
K
Q
D
E
C
R
E
Site 73
S665
C
R
E
G
F
R
Q
S
P
D
C
S
Q
P
Q
Site 74
S669
F
R
Q
S
P
D
C
S
Q
P
Q
G
A
P
A
Site 75
T689
L
C
Q
Q
C
G
K
T
F
T
R
K
K
T
L
Site 76
T695
K
T
F
T
R
K
K
T
L
V
D
H
Q
R
I
Site 77
T704
V
D
H
Q
R
I
H
T
G
E
K
P
Y
Q
C
Site 78
Y709
I
H
T
G
E
K
P
Y
Q
C
S
D
C
G
K
Site 79
S712
G
E
K
P
Y
Q
C
S
D
C
G
K
D
F
A
Site 80
Y720
D
C
G
K
D
F
A
Y
R
S
A
F
I
V
H
Site 81
S722
G
K
D
F
A
Y
R
S
A
F
I
V
H
K
K
Site 82
S742
R
K
P
E
G
G
P
S
F
S
Q
D
T
V
F
Site 83
S744
P
E
G
G
P
S
F
S
Q
D
T
V
F
Q
V
Site 84
T747
G
P
S
F
S
Q
D
T
V
F
Q
V
P
Q
S
Site 85
S754
T
V
F
Q
V
P
Q
S
S
H
S
K
E
E
P
Site 86
S755
V
F
Q
V
P
Q
S
S
H
S
K
E
E
P
Y
Site 87
Y762
S
H
S
K
E
E
P
Y
K
C
S
Q
C
G
K
Site 88
S765
K
E
E
P
Y
K
C
S
Q
C
G
K
A
F
R
Site 89
S775
G
K
A
F
R
N
H
S
F
L
L
I
H
Q
R
Site 90
T785
L
I
H
Q
R
V
H
T
G
E
K
P
Y
K
C
Site 91
Y790
V
H
T
G
E
K
P
Y
K
C
R
E
C
G
K
Site 92
S803
G
K
A
F
R
W
S
S
N
L
Y
R
H
Q
R
Site 93
Y806
F
R
W
S
S
N
L
Y
R
H
Q
R
I
H
S
Site 94
Y818
I
H
S
L
Q
K
Q
Y
D
C
H
E
S
E
K
Site 95
T826
D
C
H
E
S
E
K
T
P
N
V
E
P
K
I
Site 96
T854
K
T
F
T
R
K
R
T
L
L
D
H
K
G
I
Site 97
Y877
C
N
L
C
G
K
S
Y
D
R
N
Y
R
L
V
Site 98
Y881
G
K
S
Y
D
R
N
Y
R
L
V
N
H
Q
R
Site 99
T910
K
E
F
I
G
R
H
T
L
S
S
H
Q
R
K
Site 100
S912
F
I
G
R
H
T
L
S
S
H
Q
R
K
H
T
Site 101
S913
I
G
R
H
T
L
S
S
H
Q
R
K
H
T
R
Site 102
T919
S
S
H
Q
R
K
H
T
R
A
A
Q
A
E
R
Site 103
S927
R
A
A
Q
A
E
R
S
P
P
A
R
S
S
S
Site 104
S932
E
R
S
P
P
A
R
S
S
S
Q
D
T
K
L
Site 105
S933
R
S
P
P
A
R
S
S
S
Q
D
T
K
L
R
Site 106
S934
S
P
P
A
R
S
S
S
Q
D
T
K
L
R
L
Site 107
T937
A
R
S
S
S
Q
D
T
K
L
R
L
Q
K
L
Site 108
S960
E
D
C
K
E
A
C
S
Q
S
S
R
L
T
G
Site 109
S962
C
K
E
A
C
S
Q
S
S
R
L
T
G
L
Q
Site 110
T966
C
S
Q
S
S
R
L
T
G
L
Q
D
I
S
I
Site 111
S972
L
T
G
L
Q
D
I
S
I
G
K
K
C
H
K
Site 112
T986
K
C
S
I
C
G
K
T
F
N
K
S
S
Q
L
Site 113
S990
C
G
K
T
F
N
K
S
S
Q
L
I
S
H
K
Site 114
S991
G
K
T
F
N
K
S
S
Q
L
I
S
H
K
R
Site 115
S995
N
K
S
S
Q
L
I
S
H
K
R
F
H
T
R
Site 116
T1001
I
S
H
K
R
F
H
T
R
E
R
P
F
K
C
Site 117
S1009
R
E
R
P
F
K
C
S
K
C
G
K
T
F
R
Site 118
T1014
K
C
S
K
C
G
K
T
F
R
W
S
S
N
L
Site 119
S1019
G
K
T
F
R
W
S
S
N
L
A
R
H
M
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation