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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
EIF4A1
Full Name:
Eukaryotic initiation factor 4A-I
Alias:
ATP-dependent RNA helicase eIF4A-1; DDX2A; EC 3.6.1.-; EIF4A; EIF-4A; IF4A1
Type:
Translation; EC 3.6.1.-; RNA binding protein; Helicase
Mass (Da):
46154
Number AA:
406
UniProt ID:
P60842
International Prot ID:
IPI00025491
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
GO:0016281
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0008026
GO:0000339
PhosphoSite+
KinaseNET
Biological Process:
GO:0006412
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S4
_
_
_
_
M
S
A
S
Q
D
S
R
S
R
D
Site 2
S7
_
M
S
A
S
Q
D
S
R
S
R
D
N
G
P
Site 3
S9
S
A
S
Q
D
S
R
S
R
D
N
G
P
D
G
Site 4
S40
S
F
D
D
M
N
L
S
E
S
L
L
R
G
I
Site 5
S42
D
D
M
N
L
S
E
S
L
L
R
G
I
Y
A
Site 6
Y48
E
S
L
L
R
G
I
Y
A
Y
G
F
E
K
P
Site 7
Y50
L
L
R
G
I
Y
A
Y
G
F
E
K
P
S
A
Site 8
Y70
I
L
P
C
I
K
G
Y
D
V
I
A
Q
A
Q
Site 9
Y126
V
V
M
A
L
G
D
Y
M
G
A
S
C
H
A
Site 10
T138
C
H
A
C
I
G
G
T
N
V
R
A
E
V
Q
Site 11
T158
A
P
H
I
I
V
G
T
P
G
R
V
F
D
M
Site 12
Y170
F
D
M
L
N
R
R
Y
L
S
P
K
Y
I
K
Site 13
S172
M
L
N
R
R
Y
L
S
P
K
Y
I
K
M
F
Site 14
Y175
R
R
Y
L
S
P
K
Y
I
K
M
F
V
L
D
Site 15
Y197
R
G
F
K
D
Q
I
Y
D
I
F
Q
K
L
N
Site 16
T224
P
S
D
V
L
E
V
T
K
K
F
M
R
D
P
Site 17
Y250
L
E
G
I
R
Q
F
Y
I
N
V
E
R
E
E
Site 18
T262
R
E
E
W
K
L
D
T
L
C
D
L
Y
E
T
Site 19
T289
R
R
K
V
D
W
L
T
E
K
M
H
A
R
D
Site 20
T298
K
M
H
A
R
D
F
T
V
S
A
M
H
G
D
Site 21
S322
M
R
E
F
R
S
G
S
S
R
V
L
I
T
T
Site 22
Y347
Q
V
S
L
V
I
N
Y
D
L
P
T
N
R
E
Site 23
T351
V
I
N
Y
D
L
P
T
N
R
E
N
Y
I
H
Site 24
Y356
L
P
T
N
R
E
N
Y
I
H
R
I
G
R
G
Site 25
T383
V
T
E
E
D
K
R
T
L
R
D
I
E
T
F
Site 26
T389
R
T
L
R
D
I
E
T
F
Y
N
T
S
I
E
Site 27
Y391
L
R
D
I
E
T
F
Y
N
T
S
I
E
E
M
Site 28
S394
I
E
T
F
Y
N
T
S
I
E
E
M
P
L
N
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation