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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PRPS1
Full Name:
Ribose-phosphate pyrophosphokinase 1
Alias:
CMTX5; Phosphoribosyl pyrophosphate synthetase 1; Phosphoribosyl pyrophosphate synthetase I; PPRibP; PRS I; PRS-I; Ribose-phosphate pyrophosphokinase I
Type:
Kinase (non-protein); Nucleotide Metabolism - purine; Carbohydrate Metabolism - pentose phosphate pathway; EC 2.7.6.1
Mass (Da):
34834
Number AA:
318
UniProt ID:
P60891
International Prot ID:
IPI00219616
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0016301
GO:0000287
PhosphoSite+
KinaseNET
Biological Process:
GO:0046101
GO:0007399
GO:0009116
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S8
M
P
N
I
K
I
F
S
G
S
S
H
Q
D
L
Site 2
S10
N
I
K
I
F
S
G
S
S
H
Q
D
L
S
Q
Site 3
S11
I
K
I
F
S
G
S
S
H
Q
D
L
S
Q
K
Site 4
S16
G
S
S
H
Q
D
L
S
Q
K
I
A
D
R
L
Site 5
T40
K
K
F
S
N
Q
E
T
C
V
E
I
G
E
S
Site 6
S47
T
C
V
E
I
G
E
S
V
R
G
E
D
V
Y
Site 7
Y54
S
V
R
G
E
D
V
Y
I
V
Q
S
G
C
G
Site 8
Y94
A
V
I
P
C
F
P
Y
A
R
Q
D
K
K
D
Site 9
S103
R
Q
D
K
K
D
K
S
R
A
P
I
S
A
K
Site 10
S108
D
K
S
R
A
P
I
S
A
K
L
V
A
N
M
Site 11
Y146
D
I
P
V
D
N
L
Y
A
E
P
A
V
L
K
Site 12
T166
I
S
E
W
R
N
C
T
I
V
S
P
D
A
G
Site 13
S169
W
R
N
C
T
I
V
S
P
D
A
G
G
A
K
Site 14
T179
A
G
G
A
K
R
V
T
S
I
A
D
R
L
N
Site 15
S180
G
G
A
K
R
V
T
S
I
A
D
R
L
N
V
Site 16
T242
K
L
L
S
A
G
A
T
R
V
Y
A
I
L
T
Site 17
Y245
S
A
G
A
T
R
V
Y
A
I
L
T
H
G
I
Site 18
T274
E
A
V
V
V
T
N
T
I
P
Q
E
D
K
M
Site 19
T303
L
A
E
A
I
R
R
T
H
N
G
E
S
V
S
Site 20
S308
R
R
T
H
N
G
E
S
V
S
Y
L
F
S
H
Site 21
S310
T
H
N
G
E
S
V
S
Y
L
F
S
H
V
P
Site 22
Y311
H
N
G
E
S
V
S
Y
L
F
S
H
V
P
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation