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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PSMA6
Full Name:
Proteasome subunit alpha type-6
Alias:
27 kDa prosomal protein; IOTA; Macropain iota chain; MGC22756; MGC2333; MGC23846; Multicatalytic endopeptidase complex iota chain, p27K; P27K; PROS27; PROS-27; Proteasome (prosome, macropain) subunit, alpha type, 6; Proteasome iota chain; Proteasome subunit alpha type 6; PSA6
Type:
Proteasome complex; EC 3.4.25.1; Protease
Mass (Da):
27399
Number AA:
246
UniProt ID:
P60900
International Prot ID:
IPI00029623
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005739
GO:0005634
GO:0005839
Uniprot
OncoNet
Molecular Function:
GO:0003723
GO:0005515
GO:0004298
PhosphoSite+
KinaseNET
Biological Process:
GO:0031145
GO:0051436
GO:0051437
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S5
_
_
_
M
S
R
G
S
S
A
G
F
D
R
H
Site 2
S6
_
_
M
S
R
G
S
S
A
G
F
D
R
H
I
Site 3
T14
A
G
F
D
R
H
I
T
I
F
S
P
E
G
R
Site 4
S17
D
R
H
I
T
I
F
S
P
E
G
R
L
Y
Q
Site 5
Y23
F
S
P
E
G
R
L
Y
Q
V
E
Y
A
F
K
Site 6
Y27
G
R
L
Y
Q
V
E
Y
A
F
K
A
I
N
Q
Site 7
S39
I
N
Q
G
G
L
T
S
V
A
V
R
G
K
D
Site 8
S63
V
P
D
K
L
L
D
S
S
T
V
T
H
L
F
Site 9
S64
P
D
K
L
L
D
S
S
T
V
T
H
L
F
K
Site 10
T65
D
K
L
L
D
S
S
T
V
T
H
L
F
K
I
Site 11
S87
M
T
G
M
T
A
D
S
R
S
Q
V
Q
R
A
Site 12
S89
G
M
T
A
D
S
R
S
Q
V
Q
R
A
R
Y
Site 13
Y96
S
Q
V
Q
R
A
R
Y
E
A
A
N
W
K
Y
Site 14
Y103
Y
E
A
A
N
W
K
Y
K
Y
G
Y
E
I
P
Site 15
Y105
A
A
N
W
K
Y
K
Y
G
Y
E
I
P
V
D
Site 16
Y107
N
W
K
Y
K
Y
G
Y
E
I
P
V
D
M
L
Site 17
T126
A
D
I
S
Q
V
Y
T
Q
N
A
E
M
R
P
Site 18
Y152
E
E
Q
G
P
Q
V
Y
K
C
D
P
A
G
Y
Site 19
Y159
Y
K
C
D
P
A
G
Y
Y
C
G
F
K
A
T
Site 20
Y160
K
C
D
P
A
G
Y
Y
C
G
F
K
A
T
A
Site 21
S177
V
K
Q
T
E
S
T
S
F
L
E
K
K
V
K
Site 22
T190
V
K
K
K
F
D
W
T
F
E
Q
T
V
E
T
Site 23
T231
N
P
K
F
R
I
L
T
E
A
E
I
D
A
H
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation