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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CXCR4
Full Name:
C-X-C chemokine receptor type 4
Alias:
Stromal cell-derived factor 1 receptor
Type:
Receptor, G protein-coupled
Mass (Da):
39746
Number AA:
352
UniProt ID:
P61073
International Prot ID:
IPI00028159
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005886
GO:0005887
Uniprot
OncoNet
Molecular Function:
GO:0001584
GO:0001637
GO:0001653
PhosphoSite+
KinaseNET
Biological Process:
GO:0000187
GO:0001569
GO:0001666
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S5
_
_
_
M
E
G
I
S
I
Y
T
S
D
N
Y
Site 2
Y7
_
M
E
G
I
S
I
Y
T
S
D
N
Y
T
E
Site 3
S9
E
G
I
S
I
Y
T
S
D
N
Y
T
E
E
M
Site 4
Y12
S
I
Y
T
S
D
N
Y
T
E
E
M
G
S
G
Site 5
T13
I
Y
T
S
D
N
Y
T
E
E
M
G
S
G
D
Site 6
S18
N
Y
T
E
E
M
G
S
G
D
Y
D
S
M
K
Site 7
Y21
E
E
M
G
S
G
D
Y
D
S
M
K
E
P
C
Site 8
S23
M
G
S
G
D
Y
D
S
M
K
E
P
C
F
R
Site 9
T73
Q
K
K
L
R
S
M
T
D
K
Y
R
L
H
L
Site 10
Y76
L
R
S
M
T
D
K
Y
R
L
H
L
S
V
A
Site 11
S144
A
I
V
H
A
T
N
S
Q
R
P
R
K
L
L
Site 12
Y157
L
L
A
E
K
V
V
Y
V
G
V
W
I
P
A
Site 13
Y184
V
S
E
A
D
D
R
Y
I
C
D
R
F
Y
P
Site 14
S227
C
I
I
I
S
K
L
S
H
S
K
G
H
Q
K
Site 15
T318
T
S
A
Q
H
A
L
T
S
V
S
R
G
S
S
Site 16
S319
S
A
Q
H
A
L
T
S
V
S
R
G
S
S
L
Site 17
S321
Q
H
A
L
T
S
V
S
R
G
S
S
L
K
I
Site 18
S324
L
T
S
V
S
R
G
S
S
L
K
I
L
S
K
Site 19
S325
T
S
V
S
R
G
S
S
L
K
I
L
S
K
G
Site 20
S330
G
S
S
L
K
I
L
S
K
G
K
R
G
G
H
Site 21
S338
K
G
K
R
G
G
H
S
S
V
S
T
E
S
E
Site 22
S339
G
K
R
G
G
H
S
S
V
S
T
E
S
E
S
Site 23
S341
R
G
G
H
S
S
V
S
T
E
S
E
S
S
S
Site 24
T342
G
G
H
S
S
V
S
T
E
S
E
S
S
S
F
Site 25
S344
H
S
S
V
S
T
E
S
E
S
S
S
F
H
S
Site 26
S346
S
V
S
T
E
S
E
S
S
S
F
H
S
S
_
Site 27
S347
V
S
T
E
S
E
S
S
S
F
H
S
S
_
_
Site 28
S348
S
T
E
S
E
S
S
S
F
H
S
S
_
_
_
Site 29
S351
S
E
S
S
S
F
H
S
S
_
_
_
_
_
_
Site 30
S352
E
S
S
S
F
H
S
S
_
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation