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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PSME3
Full Name:
Proteasome activator complex subunit 3
Alias:
11S regulator complex gamma; Activator of multicatalytic protease 3; Ki; Ki nuclear autoantigen; Ki); PA28g; PA28gamma; PA28-gamma; Proteasome (prosome, macropain) activator 3 (PA28 gamma; Proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Proteasome activator 28-gamma; Proteasome activator 3; Proteasome activator complex 3; REG-gamma
Type:
Nuclear receptor co-regulator; Proteasome complex; Protease
Mass (Da):
29506
Number AA:
254
UniProt ID:
P61289
International Prot ID:
IPI00030243
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005634
GO:0008537
Uniprot
OncoNet
Molecular Function:
GO:0070215
GO:0042802
GO:0002039
PhosphoSite+
KinaseNET
Biological Process:
GO:0031145
GO:0006915
GO:0051436
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S17
E
V
K
L
K
V
D
S
F
R
E
R
I
T
S
Site 2
T23
D
S
F
R
E
R
I
T
S
E
A
E
D
L
V
Site 3
S24
S
F
R
E
R
I
T
S
E
A
E
D
L
V
A
Site 4
S60
H
D
L
T
Q
I
H
S
D
M
N
L
P
V
P
Site 5
T73
V
P
D
P
I
L
L
T
N
S
H
D
G
L
D
Site 6
Y84
D
G
L
D
G
P
T
Y
K
K
R
R
L
D
E
Site 7
S156
D
G
N
N
F
G
V
S
I
Q
E
E
T
V
A
Site 8
T167
E
T
V
A
E
L
R
T
V
E
S
E
A
A
S
Site 9
S170
A
E
L
R
T
V
E
S
E
A
A
S
Y
L
D
Site 10
S174
T
V
E
S
E
A
A
S
Y
L
D
Q
I
S
R
Site 11
Y175
V
E
S
E
A
A
S
Y
L
D
Q
I
S
R
Y
Site 12
S180
A
S
Y
L
D
Q
I
S
R
Y
Y
I
T
R
A
Site 13
Y183
L
D
Q
I
S
R
Y
Y
I
T
R
A
K
L
V
Site 14
S191
I
T
R
A
K
L
V
S
K
I
A
K
Y
P
H
Site 15
Y196
L
V
S
K
I
A
K
Y
P
H
V
E
D
Y
R
Site 16
Y202
K
Y
P
H
V
E
D
Y
R
R
T
V
T
E
I
Site 17
T205
H
V
E
D
Y
R
R
T
V
T
E
I
D
E
K
Site 18
T207
E
D
Y
R
R
T
V
T
E
I
D
E
K
E
Y
Site 19
Y214
T
E
I
D
E
K
E
Y
I
S
L
R
L
I
I
Site 20
S216
I
D
E
K
E
Y
I
S
L
R
L
I
I
S
E
Site 21
Y228
I
S
E
L
R
N
Q
Y
V
T
L
H
D
M
I
Site 22
T230
E
L
R
N
Q
Y
V
T
L
H
D
M
I
L
K
Site 23
S247
E
K
I
K
R
P
R
S
S
N
A
E
T
L
Y
Site 24
S248
K
I
K
R
P
R
S
S
N
A
E
T
L
Y
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation