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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ISL1
Full Name:
Insulin gene enhancer protein ISL-1
Alias:
Islet-
Type:
Transcription protein
Mass (Da):
39036
Number AA:
349
UniProt ID:
P61371
International Prot ID:
IPI00025071
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0003702
GO:0005515
GO:0043565
PhosphoSite+
KinaseNET
Biological Process:
GO:0006091
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S15
P
K
K
K
R
L
I
S
L
C
V
G
C
G
N
Site 2
Y28
G
N
Q
I
H
D
Q
Y
I
L
R
V
S
P
D
Site 3
S33
D
Q
Y
I
L
R
V
S
P
D
L
E
W
H
A
Site 4
Y51
K
C
A
E
C
N
Q
Y
L
D
E
S
C
T
C
Site 5
Y66
F
V
R
D
G
K
T
Y
C
K
R
D
Y
I
R
Site 6
Y71
K
T
Y
C
K
R
D
Y
I
R
L
Y
G
I
K
Site 7
Y75
K
R
D
Y
I
R
L
Y
G
I
K
C
A
K
C
Site 8
S140
H
D
V
V
E
R
A
S
L
G
A
G
D
P
L
Site 9
S148
L
G
A
G
D
P
L
S
P
L
H
P
A
R
P
Site 10
S164
Q
M
A
A
E
P
I
S
A
R
Q
P
A
L
R
Site 11
T181
V
H
K
Q
P
E
K
T
T
R
V
R
T
V
L
Site 12
T182
H
K
Q
P
E
K
T
T
R
V
R
T
V
L
N
Site 13
T186
E
K
T
T
R
V
R
T
V
L
N
E
K
Q
L
Site 14
Y200
L
H
T
L
R
T
C
Y
A
A
N
P
R
P
D
Site 15
S240
R
C
K
D
K
K
R
S
I
M
M
K
Q
L
Q
Site 16
T255
Q
Q
Q
P
N
D
K
T
N
I
Q
G
M
T
G
Site 17
S269
G
T
P
M
V
A
A
S
P
E
R
H
D
G
G
Site 18
S286
A
N
P
V
E
V
Q
S
Y
Q
P
P
W
K
V
Site 19
Y287
N
P
V
E
V
Q
S
Y
Q
P
P
W
K
V
L
Site 20
S295
Q
P
P
W
K
V
L
S
D
F
A
L
Q
S
D
Site 21
S301
L
S
D
F
A
L
Q
S
D
I
D
Q
P
A
F
Site 22
S315
F
Q
Q
L
V
N
F
S
E
G
G
P
G
S
N
Site 23
S321
F
S
E
G
G
P
G
S
N
S
T
G
S
E
V
Site 24
S323
E
G
G
P
G
S
N
S
T
G
S
E
V
A
S
Site 25
T324
G
G
P
G
S
N
S
T
G
S
E
V
A
S
M
Site 26
S326
P
G
S
N
S
T
G
S
E
V
A
S
M
S
S
Site 27
S330
S
T
G
S
E
V
A
S
M
S
S
Q
L
P
D
Site 28
S333
S
E
V
A
S
M
S
S
Q
L
P
D
T
P
N
Site 29
T338
M
S
S
Q
L
P
D
T
P
N
S
M
V
A
S
Site 30
S341
Q
L
P
D
T
P
N
S
M
V
A
S
P
I
E
Site 31
S345
T
P
N
S
M
V
A
S
P
I
E
A
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation