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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
WDR5
Full Name:
WD repeat-containing protein 5
Alias:
BIG3; BIG-3; BMP2-induced 3-kb gene; SWD3; SWD3, Set1c WD40 repeat protein; WD repeat domain 5
Type:
Adaptor/scaffold
Mass (Da):
36588
Number AA:
334
UniProt ID:
P61964
International Prot ID:
IPI00005492
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0035097
Uniprot
OncoNet
Molecular Function:
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0051568
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T18
E
A
A
R
A
Q
P
T
P
S
S
S
A
T
Q
Site 2
S20
A
R
A
Q
P
T
P
S
S
S
A
T
Q
S
K
Site 3
S21
R
A
Q
P
T
P
S
S
S
A
T
Q
S
K
P
Site 4
S22
A
Q
P
T
P
S
S
S
A
T
Q
S
K
P
T
Site 5
T24
P
T
P
S
S
S
A
T
Q
S
K
P
T
P
V
Site 6
S26
P
S
S
S
A
T
Q
S
K
P
T
P
V
K
P
Site 7
T29
S
A
T
Q
S
K
P
T
P
V
K
P
N
Y
A
Site 8
Y35
P
T
P
V
K
P
N
Y
A
L
K
F
T
L
A
Site 9
T45
K
F
T
L
A
G
H
T
K
A
V
S
S
V
K
Site 10
S49
A
G
H
T
K
A
V
S
S
V
K
F
S
P
N
Site 11
S50
G
H
T
K
A
V
S
S
V
K
F
S
P
N
G
Site 12
S54
A
V
S
S
V
K
F
S
P
N
G
E
W
L
A
Site 13
S62
P
N
G
E
W
L
A
S
S
S
A
D
K
L
I
Site 14
S63
N
G
E
W
L
A
S
S
S
A
D
K
L
I
K
Site 15
T82
Y
D
G
K
F
E
K
T
I
S
G
H
K
L
G
Site 16
S84
G
K
F
E
K
T
I
S
G
H
K
L
G
I
S
Site 17
S91
S
G
H
K
L
G
I
S
D
V
A
W
S
S
D
Site 18
S99
D
V
A
W
S
S
D
S
N
L
L
V
S
A
S
Site 19
S104
S
D
S
N
L
L
V
S
A
S
D
D
K
T
L
Site 20
S106
S
N
L
L
V
S
A
S
D
D
K
T
L
K
I
Site 21
T110
V
S
A
S
D
D
K
T
L
K
I
W
D
V
S
Site 22
T124
S
S
G
K
C
L
K
T
L
K
G
H
S
N
Y
Site 23
Y131
T
L
K
G
H
S
N
Y
V
F
C
C
N
F
N
Site 24
S146
P
Q
S
N
L
I
V
S
G
S
F
D
E
S
V
Site 25
S152
V
S
G
S
F
D
E
S
V
R
I
W
D
V
K
Site 26
T166
K
T
G
K
C
L
K
T
L
P
A
H
S
D
P
Site 27
S171
L
K
T
L
P
A
H
S
D
P
V
S
A
V
H
Site 28
S175
P
A
H
S
D
P
V
S
A
V
H
F
N
R
D
Site 29
S184
V
H
F
N
R
D
G
S
L
I
V
S
S
S
Y
Site 30
S188
R
D
G
S
L
I
V
S
S
S
Y
D
G
L
C
Site 31
S189
D
G
S
L
I
V
S
S
S
Y
D
G
L
C
R
Site 32
T208
A
S
G
Q
C
L
K
T
L
I
D
D
D
N
P
Site 33
S218
D
D
D
N
P
P
V
S
F
V
K
F
S
P
N
Site 34
T237
L
A
A
T
L
D
N
T
L
K
L
W
D
Y
S
Site 35
Y243
N
T
L
K
L
W
D
Y
S
K
G
K
C
L
K
Site 36
T251
S
K
G
K
C
L
K
T
Y
T
G
H
K
N
E
Site 37
Y252
K
G
K
C
L
K
T
Y
T
G
H
K
N
E
K
Site 38
Y260
T
G
H
K
N
E
K
Y
C
I
F
A
N
F
S
Site 39
Y284
G
S
E
D
N
L
V
Y
I
W
N
L
Q
T
K
Site 40
T290
V
Y
I
W
N
L
Q
T
K
E
I
V
Q
K
L
Site 41
T326
A
A
L
E
N
D
K
T
I
K
L
W
K
S
D
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation