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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
USP46
Full Name:
Ubiquitin carboxyl-terminal hydrolase 46
Alias:
Deubiquitinating enzyme 46; EC 3.1.2.15; Ubiquitin thioesterase 46; Ubiquitin-specific-processing protease 46
Type:
Enzyme, Ubiquitin-specific-processing protease
Mass (Da):
42442
Number AA:
366
UniProt ID:
P62068
International Prot ID:
IPI00303458
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0004221
GO:0004843
PhosphoSite+
KinaseNET
Biological Process:
GO:0007610
GO:0016579
GO:0032228
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y34
Q
F
P
I
N
E
H
Y
F
G
L
V
N
F
G
Site 2
Y54
N
S
V
L
Q
A
L
Y
F
C
R
P
F
R
E
Site 3
T78
K
K
K
E
N
L
L
T
C
L
A
D
L
F
H
Site 4
S104
I
P
P
K
K
F
I
S
R
L
R
K
E
N
D
Site 5
Y116
E
N
D
L
F
D
N
Y
M
Q
Q
D
A
H
E
Site 6
Y127
D
A
H
E
F
L
N
Y
L
L
N
T
I
A
D
Site 7
T177
E
I
F
Q
G
T
L
T
N
E
T
R
C
L
N
Site 8
T187
T
R
C
L
N
C
E
T
V
S
S
K
D
E
D
Site 9
S190
L
N
C
E
T
V
S
S
K
D
E
D
F
L
D
Site 10
S199
D
E
D
F
L
D
L
S
V
D
V
E
Q
N
T
Site 11
S207
V
D
V
E
Q
N
T
S
I
T
H
C
L
R
D
Site 12
S216
T
H
C
L
R
D
F
S
N
T
E
T
L
C
S
Site 13
T218
C
L
R
D
F
S
N
T
E
T
L
C
S
E
Q
Site 14
T220
R
D
F
S
N
T
E
T
L
C
S
E
Q
K
Y
Site 15
Y227
T
L
C
S
E
Q
K
Y
Y
C
E
T
C
C
S
Site 16
Y228
L
C
S
E
Q
K
Y
Y
C
E
T
C
C
S
K
Site 17
Y260
L
H
L
K
R
F
K
Y
M
E
Q
L
H
R
Y
Site 18
Y267
Y
M
E
Q
L
H
R
Y
T
K
L
S
Y
R
V
Site 19
T268
M
E
Q
L
H
R
Y
T
K
L
S
Y
R
V
V
Site 20
S271
L
H
R
Y
T
K
L
S
Y
R
V
V
F
P
L
Site 21
Y272
H
R
Y
T
K
L
S
Y
R
V
V
F
P
L
E
Site 22
S286
E
L
R
L
F
N
T
S
S
D
A
V
N
L
D
Site 23
S287
L
R
L
F
N
T
S
S
D
A
V
N
L
D
R
Site 24
Y314
S
G
P
N
R
G
H
Y
I
T
I
V
K
S
H
Site 25
T316
P
N
R
G
H
Y
I
T
I
V
K
S
H
G
F
Site 26
S320
H
Y
I
T
I
V
K
S
H
G
F
W
L
L
F
Site 27
S348
E
E
F
Y
G
L
T
S
D
I
S
K
N
S
E
Site 28
S351
Y
G
L
T
S
D
I
S
K
N
S
E
S
G
Y
Site 29
S354
T
S
D
I
S
K
N
S
E
S
G
Y
I
L
F
Site 30
Y358
S
K
N
S
E
S
G
Y
I
L
F
Y
Q
S
R
Site 31
Y362
E
S
G
Y
I
L
F
Y
Q
S
R
E
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation