PhosphoNET

           
Protein Info 
   
Short Name:  PPP1CA
Full Name:  Serine/threonine-protein phosphatase PP1-alpha catalytic subunit
Alias:  EC 3.1.3.16; PP1A; PP-1A; PPP1A; Protein phosphatase 1, catalytic subunit, alpha isoform; Serine/threonine protein phosphatase PP1-alpha 1 catalytic subunit; Serine/threonine protein phosphatase PP1-alpha 1, catalytic subunit
Type:  Protein phosphatase, Ser/Thr (non-receptor); EC 3.1.3.16
Mass (Da):  37512
Number AA:  330
UniProt ID:  P62136
International Prot ID:  IPI00550451
Sequence:  Retrieve full protein sequence
   
GO Terms  External Links Internal Links  
   
Cellular Component:  GO:0070688  GO:0005829   Uniprot OncoNet
Molecular Function:  GO:0005506  GO:0030145  GO:0005515 PhosphoSite+ KinaseNET
Biological Process:  GO:0007049  GO:0051301  GO:0005977 Phosida TranscriptoNet
    STRING Kinexus Products
   
Info Box  A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites 
-7-6-5-4-3-2-101234567Expt. conf.EffectKinasePPaseKinexus ProductsRef.Evol.Kinase Pred.P-site Match
Site 1S2______MSDSEKLNL
Site 2S4____MSDSEKLNLDS
Site 3S11SEKLNLDSIIGRLLE
Site 4S22RLLEVQGSRPGKNVQ
Site 5T31PGKNVQLTENEIRGL
Site 6S42IRGLCLKSREIFLSQ
Site 7S48KSREIFLSQPILLEL
Site 8Y69CGDIHGQYYDLLRLF
Site 9Y70GDIHGQYYDLLRLFE
Site 10Y78DLLRLFEYGGFPPES
Site 11S85YGGFPPESNYLFLGD
Site 12Y87GFPPESNYLFLGDYV
Site 13Y93NYLFLGDYVDRGKQS
Site 14S100YVDRGKQSLETICLL
Site 15Y134CASINRIYGFYDECK
Site 16Y137INRIYGFYDECKRRY
Site 17Y144YDECKRRYNIKLWKT
Site 18S177FCCHGGLSPDLQSME
Site 19S182GLSPDLQSMEQIRRI
Site 20T193IRRIMRPTDVPDQGL
Site 21S207LLCDLLWSDPDKDVQ
Site 22S224GENDRGVSFTFGAEV
Site 23Y255HQVVEDGYEFFAKRQ
Site 24T265FAKRQLVTLFSAPNY
Site 25S268RQLVTLFSAPNYCGE
Site 26Y272TLFSAPNYCGEFDNA
Site 27Y306ADKNKGKYGQFSGLN
Site 28S310KGKYGQFSGLNPGGR
Site 29T320NPGGRPITPPRNSAK
Site 30S325PITPPRNSAKAKK__
 
Legend 
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available  
Products available
 


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