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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PSMC1
Full Name:
26S protease regulatory subunit 4
Alias:
P26s4; p56; proteasome (prosome, macropain) 26S subunit, ATPase, 1; proteasome 26S subunit ATPase 1; PRS4; S4
Type:
Proteasome complex; Protease
Mass (Da):
49185
Number AA:
440
UniProt ID:
P62191
International Prot ID:
IPI00011126
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005634
GO:0000502
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0016887
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0031145
GO:0051436
GO:0051437
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S4
_
_
_
_
M
G
Q
S
Q
S
G
G
H
G
P
Site 2
S6
_
_
M
G
Q
S
Q
S
G
G
H
G
P
G
G
Site 3
Y25
D
K
D
K
K
K
K
Y
E
P
P
V
P
T
R
Site 4
T40
V
G
K
K
K
K
K
T
K
G
P
D
A
A
S
Site 5
T53
A
S
K
L
P
L
V
T
P
H
T
Q
C
R
L
Site 6
Y71
K
L
E
R
I
K
D
Y
L
L
M
E
E
E
F
Site 7
S97
E
K
Q
E
E
E
R
S
K
V
D
D
L
R
G
Site 8
T105
K
V
D
D
L
R
G
T
P
M
S
V
G
T
L
Site 9
S108
D
L
R
G
T
P
M
S
V
G
T
L
E
E
I
Site 10
T125
D
N
H
A
I
V
S
T
S
V
G
S
E
H
Y
Site 11
S126
N
H
A
I
V
S
T
S
V
G
S
E
H
Y
V
Site 12
Y132
T
S
V
G
S
E
H
Y
V
S
I
L
S
F
V
Site 13
Y184
E
K
A
P
Q
E
T
Y
A
D
I
G
G
L
D
Site 14
S200
Q
I
Q
E
I
K
E
S
V
E
L
P
L
T
H
Site 15
T206
E
S
V
E
L
P
L
T
H
P
E
Y
Y
E
E
Site 16
Y210
L
P
L
T
H
P
E
Y
Y
E
E
M
G
I
K
Site 17
Y211
P
L
T
H
P
E
Y
Y
E
E
M
G
I
K
P
Site 18
Y225
P
P
K
G
V
I
L
Y
G
P
P
G
T
G
K
Site 19
Y259
G
S
E
L
I
Q
K
Y
L
G
D
G
P
K
L
Site 20
Y295
D
A
I
G
T
K
R
Y
D
S
N
S
G
G
E
Site 21
S297
I
G
T
K
R
Y
D
S
N
S
G
G
E
R
E
Site 22
S299
T
K
R
Y
D
S
N
S
G
G
E
R
E
I
Q
Site 23
T308
G
E
R
E
I
Q
R
T
M
L
E
L
L
N
Q
Site 24
S321
N
Q
L
D
G
F
D
S
R
G
D
V
K
V
I
Site 25
T336
M
A
T
N
R
I
E
T
L
D
P
A
L
I
R
Site 26
T360
F
P
L
P
D
E
K
T
K
K
R
I
F
Q
I
Site 27
T369
K
R
I
F
Q
I
H
T
S
R
M
T
L
A
D
Site 28
T373
Q
I
H
T
S
R
M
T
L
A
D
D
V
T
L
Site 29
T415
R
E
R
R
M
K
V
T
N
E
D
F
K
K
S
Site 30
S422
T
N
E
D
F
K
K
S
K
E
N
V
L
Y
K
Site 31
Y428
K
S
K
E
N
V
L
Y
K
K
Q
E
G
T
P
Site 32
T434
L
Y
K
K
Q
E
G
T
P
E
G
L
Y
L
_
Site 33
Y439
E
G
T
P
E
G
L
Y
L
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation