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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PSMC5
Full Name:
26S protease regulatory subunit 8
Alias:
P45; P45/SUG; Proteasome (prosome, macropain) 26S subunit, ATPase, 5; Proteasome 26S subunit ATPase 5; Proteasome subunit p45; PRS8; S8; SUG1; SUG-1; TBP10; Thyroid hormone receptor interacting protein 1; TRIP1
Type:
Ubiquitin conjugating system; Nuclear receptor co-regulator
Mass (Da):
45626
Number AA:
406
UniProt ID:
P62195
International Prot ID:
IPI00023919
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005634
GO:0000502
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0016887
GO:0031531
PhosphoSite+
KinaseNET
Biological Process:
GO:0031145
GO:0043069
GO:0051436
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S18
L
E
E
G
K
A
G
S
G
L
R
Q
Y
Y
L
Site 2
Y23
A
G
S
G
L
R
Q
Y
Y
L
S
K
I
E
E
Site 3
Y24
G
S
G
L
R
Q
Y
Y
L
S
K
I
E
E
L
Site 4
S26
G
L
R
Q
Y
Y
L
S
K
I
E
E
L
Q
L
Site 5
S39
Q
L
I
V
N
D
K
S
Q
N
L
R
R
L
Q
Site 6
S71
Q
L
L
Q
E
Q
G
S
Y
V
G
E
V
V
R
Site 7
Y72
L
L
Q
E
Q
G
S
Y
V
G
E
V
V
R
A
Site 8
S120
R
V
A
L
R
N
D
S
Y
T
L
H
K
I
L
Site 9
Y121
V
A
L
R
N
D
S
Y
T
L
H
K
I
L
P
Site 10
T122
A
L
R
N
D
S
Y
T
L
H
K
I
L
P
N
Site 11
S136
N
K
V
D
P
L
V
S
L
M
M
V
E
K
V
Site 12
S146
M
V
E
K
V
P
D
S
T
Y
E
M
I
G
G
Site 13
T147
V
E
K
V
P
D
S
T
Y
E
M
I
G
G
L
Site 14
Y148
E
K
V
P
D
S
T
Y
E
M
I
G
G
L
D
Site 15
Y189
Q
P
K
G
V
L
L
Y
G
P
P
G
T
G
K
Site 16
S215
D
C
T
F
I
R
V
S
G
S
E
L
V
Q
K
Site 17
S253
I
F
M
D
E
I
D
S
I
G
S
S
R
L
E
Site 18
S256
D
E
I
D
S
I
G
S
S
R
L
E
G
G
S
Site 19
S257
E
I
D
S
I
G
S
S
R
L
E
G
G
S
G
Site 20
S263
S
S
R
L
E
G
G
S
G
G
D
S
E
V
Q
Site 21
S267
E
G
G
S
G
G
D
S
E
V
Q
R
T
M
L
Site 22
T272
G
D
S
E
V
Q
R
T
M
L
E
L
L
N
Q
Site 23
S303
N
R
I
D
I
L
D
S
A
L
L
R
P
G
R
Site 24
T339
H
S
R
K
M
N
L
T
R
G
I
N
L
R
K
Site 25
T364
A
E
V
K
G
V
C
T
E
A
G
M
Y
A
L
Site 26
Y369
V
C
T
E
A
G
M
Y
A
L
R
E
R
R
V
Site 27
T379
R
E
R
R
V
H
V
T
Q
E
D
F
E
M
A
Site 28
S395
A
K
V
M
Q
K
D
S
E
K
N
M
S
I
K
Site 29
S400
K
D
S
E
K
N
M
S
I
K
K
L
W
K
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation