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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
YWHAE
Full Name:
14-3-3 protein epsilon
Alias:
14-3-3 protein sigma; 14-3-3E; MVP
Type:
Adapter/scaffold protein
Mass (Da):
29174
Number AA:
255
UniProt ID:
P62258
International Prot ID:
IPI00000816
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
GO:0042470
GO:0016023
Uniprot
OncoNet
Molecular Function:
GO:0042826
GO:0050815
GO:0019899
PhosphoSite+
KinaseNET
Biological Process:
GO:0006915
GO:0008624
GO:0044419
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y9
D
D
R
E
D
L
V
Y
Q
A
K
L
A
E
Q
Site 2
Y20
L
A
E
Q
A
E
R
Y
D
E
M
V
E
S
M
Site 3
T38
A
G
M
D
V
E
L
T
V
E
E
R
N
L
L
Site 4
S46
V
E
E
R
N
L
L
S
V
A
Y
K
N
V
I
Site 5
Y49
R
N
L
L
S
V
A
Y
K
N
V
I
G
A
R
Site 6
S64
R
A
S
W
R
I
I
S
S
I
E
Q
K
E
E
Site 7
S65
A
S
W
R
I
I
S
S
I
E
Q
K
E
E
N
Site 8
Y85
K
L
K
M
I
R
E
Y
R
Q
M
V
E
T
E
Site 9
T91
E
Y
R
Q
M
V
E
T
E
L
K
L
I
C
C
Site 10
Y121
T
G
E
S
K
V
F
Y
Y
K
M
K
G
D
Y
Site 11
Y122
G
E
S
K
V
F
Y
Y
K
M
K
G
D
Y
H
Site 12
Y128
Y
Y
K
M
K
G
D
Y
H
R
Y
L
A
E
F
Site 13
Y131
M
K
G
D
Y
H
R
Y
L
A
E
F
A
T
G
Site 14
T137
R
Y
L
A
E
F
A
T
G
N
D
R
K
E
A
Site 15
S148
R
K
E
A
A
E
N
S
L
V
A
Y
K
A
A
Site 16
T161
A
A
S
D
I
A
M
T
E
L
P
P
T
H
P
Site 17
Y181
A
L
N
F
S
V
F
Y
Y
E
I
L
N
S
P
Site 18
Y182
L
N
F
S
V
F
Y
Y
E
I
L
N
S
P
D
Site 19
S187
F
Y
Y
E
I
L
N
S
P
D
R
A
C
R
L
Site 20
T208
D
A
I
A
E
L
D
T
L
S
E
E
S
Y
K
Site 21
S210
I
A
E
L
D
T
L
S
E
E
S
Y
K
D
S
Site 22
S213
L
D
T
L
S
E
E
S
Y
K
D
S
T
L
I
Site 23
Y214
D
T
L
S
E
E
S
Y
K
D
S
T
L
I
M
Site 24
S217
S
E
E
S
Y
K
D
S
T
L
I
M
Q
L
L
Site 25
T218
E
E
S
Y
K
D
S
T
L
I
M
Q
L
L
R
Site 26
T229
Q
L
L
R
D
N
L
T
L
W
T
S
D
M
Q
Site 27
S233
D
N
L
T
L
W
T
S
D
M
Q
G
D
G
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation