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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PSMC6
Full Name:
26S protease regulatory subunit 10B
Alias:
P42; Proteasome (prosome, macropain) 26S subunit, ATPase, 6; Proteasome 26S subunit ATPase 6; Proteasome subunit p42; PRS10; SUG2
Type:
Proteasome complex; Protease
Mass (Da):
44173
Number AA:
389
UniProt ID:
P62333
International Prot ID:
IPI00021926
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005634
GO:0000502
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0016887
GO:0030674
PhosphoSite+
KinaseNET
Biological Process:
GO:0031145
GO:0051436
GO:0051437
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y12
R
D
K
A
L
Q
D
Y
R
K
K
L
L
E
H
Site 2
S43
L
T
K
Q
Y
E
K
S
E
N
D
L
K
A
L
Site 3
S52
N
D
L
K
A
L
Q
S
V
G
Q
I
V
G
E
Site 4
Y79
K
A
T
N
G
P
R
Y
V
V
G
C
R
R
Q
Site 5
S90
C
R
R
Q
L
D
K
S
K
L
K
P
G
T
R
Site 6
T104
R
V
A
L
D
M
T
T
L
T
I
M
R
Y
L
Site 7
Y110
T
T
L
T
I
M
R
Y
L
P
R
E
V
D
P
Site 8
S123
D
P
L
V
Y
N
M
S
H
E
D
P
G
N
V
Site 9
S131
H
E
D
P
G
N
V
S
Y
S
E
I
G
G
L
Site 10
Y132
E
D
P
G
N
V
S
Y
S
E
I
G
G
L
S
Site 11
S133
D
P
G
N
V
S
Y
S
E
I
G
G
L
S
E
Site 12
S139
Y
S
E
I
G
G
L
S
E
Q
I
R
E
L
R
Site 13
T154
E
V
I
E
L
P
L
T
N
P
E
L
F
Q
R
Site 14
Y173
P
P
K
G
C
L
L
Y
G
P
P
G
T
G
K
Site 15
S201
N
F
L
K
V
V
S
S
S
I
V
D
K
Y
I
Site 16
S202
F
L
K
V
V
S
S
S
I
V
D
K
Y
I
G
Site 17
Y207
S
S
S
I
V
D
K
Y
I
G
E
S
A
R
L
Site 18
S211
V
D
K
Y
I
G
E
S
A
R
L
I
R
E
M
Site 19
Y221
L
I
R
E
M
F
N
Y
A
R
D
H
Q
P
C
Site 20
S244
A
I
G
G
R
R
F
S
E
G
T
S
A
D
R
Site 21
T247
G
R
R
F
S
E
G
T
S
A
D
R
E
I
Q
Site 22
S248
R
R
F
S
E
G
T
S
A
D
R
E
I
Q
R
Site 23
T256
A
D
R
E
I
Q
R
T
L
M
E
L
L
N
Q
Site 24
T279
R
V
K
M
I
M
A
T
N
R
P
D
T
L
D
Site 25
T284
M
A
T
N
R
P
D
T
L
D
P
A
L
L
R
Site 26
T321
K
I
H
A
G
P
I
T
K
H
G
E
I
D
Y
Site 27
Y328
T
K
H
G
E
I
D
Y
E
A
I
V
K
L
S
Site 28
S377
A
V
R
K
V
A
D
S
K
K
L
E
S
K
L
Site 29
Y386
K
L
E
S
K
L
D
Y
K
P
V
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation