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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ACTA2
Full Name:
Actin, aortic smooth muscle
Alias:
ACTA; Actin, alpha 2; Actin, alpha 2, smooth muscle, aorta; ACTSA; ACTVS; Alpha-actin-2; Cell growth-inhibiting 46; GIG46
Type:
Actin
Mass (Da):
42009
Number AA:
377
UniProt ID:
P62736
International Prot ID:
IPI00008603
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T8
M
C
E
E
E
D
S
T
A
L
V
C
D
N
G
Site 2
S35
A
P
R
A
V
F
P
S
I
V
G
R
P
R
H
Site 3
S54
V
G
M
G
Q
K
D
S
Y
V
G
D
E
A
Q
Site 4
Y55
G
M
G
Q
K
D
S
Y
V
G
D
E
A
Q
S
Site 5
S62
Y
V
G
D
E
A
Q
S
K
R
G
I
L
T
L
Site 6
T68
Q
S
K
R
G
I
L
T
L
K
Y
P
I
E
H
Site 7
Y71
R
G
I
L
T
L
K
Y
P
I
E
H
G
I
I
Site 8
T79
P
I
E
H
G
I
I
T
N
W
D
D
M
E
K
Site 9
Y93
K
I
W
H
H
S
F
Y
N
E
L
R
V
A
P
Site 10
T105
V
A
P
E
E
H
P
T
L
L
T
E
A
P
L
Site 11
T108
E
E
H
P
T
L
L
T
E
A
P
L
N
P
K
Site 12
T128
M
T
Q
I
M
F
E
T
F
N
V
P
A
M
Y
Site 13
Y145
I
Q
A
V
L
S
L
Y
A
S
G
R
T
T
G
Site 14
S157
T
T
G
I
V
L
D
S
G
D
G
V
T
H
N
Site 15
Y168
V
T
H
N
V
P
I
Y
E
G
Y
A
L
P
H
Site 16
Y171
N
V
P
I
Y
E
G
Y
A
L
P
H
A
I
M
Site 17
Y190
A
G
R
D
L
T
D
Y
L
M
K
I
L
T
E
Site 18
T196
D
Y
L
M
K
I
L
T
E
R
G
Y
S
F
V
Site 19
Y200
K
I
L
T
E
R
G
Y
S
F
V
T
T
A
E
Site 20
S201
I
L
T
E
R
G
Y
S
F
V
T
T
A
E
R
Site 21
T205
R
G
Y
S
F
V
T
T
A
E
R
E
I
V
R
Site 22
Y220
D
I
K
E
K
L
C
Y
V
A
L
D
F
E
N
Site 23
T231
D
F
E
N
E
M
A
T
A
A
S
S
S
S
L
Site 24
S235
E
M
A
T
A
A
S
S
S
S
L
E
K
S
Y
Site 25
S237
A
T
A
A
S
S
S
S
L
E
K
S
Y
E
L
Site 26
S241
S
S
S
S
L
E
K
S
Y
E
L
P
D
G
Q
Site 27
Y242
S
S
S
L
E
K
S
Y
E
L
P
D
G
Q
V
Site 28
T251
L
P
D
G
Q
V
I
T
I
G
N
E
R
F
R
Site 29
T262
E
R
F
R
C
P
E
T
L
F
Q
P
S
F
I
Site 30
S267
P
E
T
L
F
Q
P
S
F
I
G
M
E
S
A
Site 31
T279
E
S
A
G
I
H
E
T
T
Y
N
S
I
M
K
Site 32
T280
S
A
G
I
H
E
T
T
Y
N
S
I
M
K
C
Site 33
Y281
A
G
I
H
E
T
T
Y
N
S
I
M
K
C
D
Site 34
S283
I
H
E
T
T
Y
N
S
I
M
K
C
D
I
D
Site 35
Y296
I
D
I
R
K
D
L
Y
A
N
N
V
L
S
G
Site 36
T305
N
N
V
L
S
G
G
T
T
M
Y
P
G
I
A
Site 37
T306
N
V
L
S
G
G
T
T
M
Y
P
G
I
A
D
Site 38
Y308
L
S
G
G
T
T
M
Y
P
G
I
A
D
R
M
Site 39
T320
D
R
M
Q
K
E
I
T
A
L
A
P
S
T
M
Site 40
S325
E
I
T
A
L
A
P
S
T
M
K
I
K
I
I
Site 41
T326
I
T
A
L
A
P
S
T
M
K
I
K
I
I
A
Site 42
Y339
I
A
P
P
E
R
K
Y
S
V
W
I
G
G
S
Site 43
S340
A
P
P
E
R
K
Y
S
V
W
I
G
G
S
I
Site 44
Y364
M
W
I
S
K
Q
E
Y
D
E
A
G
P
S
I
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation