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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
RPS6
Full Name:
40S ribosomal protein S6
Alias:
Phosphoprotein NP33; Ribosomal protein S6; RS6; S6 Ribosomal Protein
Type:
Protein synthesis, 40S ribosome
Mass (Da):
28681
Number AA:
249
UniProt ID:
P62753
International Prot ID:
IPI00021840
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0022627
GO:0005730
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0003735
PhosphoSite+
KinaseNET
Biological Process:
GO:0031929
GO:0042593
GO:0043065
Phosida
TranscriptoNet
STRING
Kinexus Products
40S Ribosomal S6 S235+S236+S240 phosphosite-specific antibody AB-PN559#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PN559#40S Ribosomal S6 (R232-S242, human) pS235+pS236+pS240 phosphopeptide - Powder PE-04AQR95#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04AQR95
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S6
_
_
M
K
L
N
I
S
F
P
A
T
G
C
Q
Site 2
T10
L
N
I
S
F
P
A
T
G
C
Q
K
L
I
E
Site 3
T26
D
D
E
R
K
L
R
T
F
Y
E
K
R
M
A
Site 4
Y28
E
R
K
L
R
T
F
Y
E
K
R
M
A
T
E
Site 5
T34
F
Y
E
K
R
M
A
T
E
V
A
A
D
A
L
Site 6
Y48
L
G
E
E
W
K
G
Y
V
V
R
I
S
G
G
Site 7
S53
K
G
Y
V
V
R
I
S
G
G
N
D
K
Q
G
Site 8
T69
P
M
K
Q
G
V
L
T
H
G
R
V
R
L
L
Site 9
S78
G
R
V
R
L
L
L
S
K
G
H
S
C
Y
R
Site 10
S82
L
L
L
S
K
G
H
S
C
Y
R
P
R
R
T
Site 11
Y84
L
S
K
G
H
S
C
Y
R
P
R
R
T
G
E
Site 12
T89
S
C
Y
R
P
R
R
T
G
E
R
K
R
K
S
Site 13
S96
T
G
E
R
K
R
K
S
V
R
G
C
I
V
D
Site 14
T125
E
K
D
I
P
G
L
T
D
T
T
V
P
R
R
Site 15
T127
D
I
P
G
L
T
D
T
T
V
P
R
R
L
G
Site 16
T128
I
P
G
L
T
D
T
T
V
P
R
R
L
G
P
Site 17
S139
R
L
G
P
K
R
A
S
R
I
R
K
L
F
N
Site 18
S148
I
R
K
L
F
N
L
S
K
E
D
D
V
R
Q
Site 19
Y156
K
E
D
D
V
R
Q
Y
V
V
R
K
P
L
N
Site 20
T171
K
E
G
K
K
P
R
T
K
A
P
K
I
Q
R
Site 21
T181
P
K
I
Q
R
L
V
T
P
R
V
L
Q
H
K
Site 22
Y209
N
K
E
E
A
A
E
Y
A
K
L
L
A
K
R
Site 23
S235
I
A
K
R
R
R
L
S
S
L
R
A
S
T
S
40S Ribosomal S6 S235+S236+S240 phosphosite-specific antibody AB-PN559#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PN559#40S Ribosomal S6 (R232-S242, human) pS235+pS236+pS240 phosphopeptide - Powder PE-04AQR95#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04AQR95
Site 24
S236
A
K
R
R
R
L
S
S
L
R
A
S
T
S
K
40S Ribosomal S6 S235+S236+S240 phosphosite-specific antibody AB-PN559#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PN559#40S Ribosomal S6 (R232-S242, human) pS235+pS236+pS240 phosphopeptide - Powder PE-04AQR95#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04AQR95
Site 25
S240
R
L
S
S
L
R
A
S
T
S
K
S
E
S
S
40S Ribosomal S6 S235+S236+S240 phosphosite-specific antibody AB-PN559#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PN559#40S Ribosomal S6 (R232-S242, human) pS235+pS236+pS240 phosphopeptide - Powder PE-04AQR95#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04AQR95
Site 26
T241
L
S
S
L
R
A
S
T
S
K
S
E
S
S
Q
Site 27
S242
S
S
L
R
A
S
T
S
K
S
E
S
S
Q
K
Site 28
S244
L
R
A
S
T
S
K
S
E
S
S
Q
K
_
_
Site 29
S246
A
S
T
S
K
S
E
S
S
Q
K
_
_
_
_
Site 30
S247
S
T
S
K
S
E
S
S
Q
K
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation