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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
AP2B1
Full Name:
AP-2 complex subunit beta
Alias:
adapter-related protein complex 2 beta 1 subunit; adaptin, beta; adaptor-related protein complex 2, beta 1 subunit; ADTB2; AP105B; beta-adaptin; CLAPB1; clathrin assembly protein complex 2 beta large chain; plasma membrane adaptor HA2/AP2 adaptin beta subunit
Type:
Vesicle protein
Mass (Da):
104553
Number AA:
937
UniProt ID:
P63010
International Prot ID:
IPI00784156
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0030131
GO:0005905
GO:0005829
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0008565
PhosphoSite+
KinaseNET
Biological Process:
GO:0006886
GO:0050690
GO:0016192
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T2
_
_
_
_
_
_
M
T
D
S
K
Y
F
T
T
Site 2
S4
_
_
_
_
M
T
D
S
K
Y
F
T
T
N
K
Site 3
Y6
_
_
M
T
D
S
K
Y
F
T
T
N
K
K
G
Site 4
T8
M
T
D
S
K
Y
F
T
T
N
K
K
G
E
I
Site 5
Y76
V
Y
L
Y
L
M
N
Y
A
K
S
Q
P
D
M
Site 6
S90
M
A
I
M
A
V
N
S
F
V
K
D
C
E
D
Site 7
Y121
R
V
D
K
I
T
E
Y
L
C
E
P
L
R
K
Site 8
Y136
C
L
K
D
E
D
P
Y
V
R
K
T
A
A
V
Site 9
T140
E
D
P
Y
V
R
K
T
A
A
V
C
V
A
K
Site 10
S164
E
D
Q
G
F
L
D
S
L
R
D
L
I
A
D
Site 11
S185
A
N
A
V
A
A
L
S
E
I
S
E
S
H
P
Site 12
S190
A
L
S
E
I
S
E
S
H
P
N
S
N
L
L
Site 13
S194
I
S
E
S
H
P
N
S
N
L
L
D
L
N
P
Site 14
T245
Q
S
I
C
E
R
V
T
P
R
L
S
H
A
N
Site 15
S249
E
R
V
T
P
R
L
S
H
A
N
S
A
V
V
Site 16
S274
L
E
L
L
P
K
D
S
D
Y
Y
N
M
L
L
Site 17
Y276
L
L
P
K
D
S
D
Y
Y
N
M
L
L
K
K
Site 18
Y277
L
P
K
D
S
D
Y
Y
N
M
L
L
K
K
L
Site 19
S293
P
P
L
V
T
L
L
S
G
E
P
E
V
Q
Y
Site 20
Y300
S
G
E
P
E
V
Q
Y
V
A
L
R
N
I
N
Site 21
Y333
V
K
Y
N
D
P
I
Y
V
K
L
E
K
L
D
Site 22
S347
D
I
M
I
R
L
A
S
Q
A
N
I
A
Q
V
Site 23
Y361
V
L
A
E
L
K
E
Y
A
T
E
V
D
V
D
Site 24
S393
Q
S
A
E
R
C
V
S
T
L
L
D
L
I
Q
Site 25
T394
S
A
E
R
C
V
S
T
L
L
D
L
I
Q
T
Site 26
Y421
I
R
D
I
F
R
K
Y
P
N
K
Y
E
S
I
Site 27
Y425
F
R
K
Y
P
N
K
Y
E
S
I
I
A
T
L
Site 28
T431
K
Y
E
S
I
I
A
T
L
C
E
N
L
D
S
Site 29
S438
T
L
C
E
N
L
D
S
L
D
E
P
D
A
R
Site 30
S468
N
A
D
E
L
L
E
S
F
L
E
G
F
H
D
Site 31
S477
L
E
G
F
H
D
E
S
T
Q
V
Q
L
T
L
Site 32
T478
E
G
F
H
D
E
S
T
Q
V
Q
L
T
L
L
Site 33
S497
K
L
F
L
K
K
P
S
E
T
Q
E
L
V
Q
Site 34
S508
E
L
V
Q
Q
V
L
S
L
A
T
Q
D
S
D
Site 35
S514
L
S
L
A
T
Q
D
S
D
N
P
D
L
R
D
Site 36
Y524
P
D
L
R
D
R
G
Y
I
Y
W
R
L
L
S
Site 37
Y526
L
R
D
R
G
Y
I
Y
W
R
L
L
S
T
D
Site 38
S531
Y
I
Y
W
R
L
L
S
T
D
P
V
T
A
K
Site 39
S543
T
A
K
E
V
V
L
S
E
K
P
L
I
S
E
Site 40
S572
C
H
I
G
S
L
A
S
V
Y
H
K
P
P
N
Site 41
Y574
I
G
S
L
A
S
V
Y
H
K
P
P
N
A
F
Site 42
S605
G
S
T
D
A
G
D
S
P
V
G
T
T
T
A
Site 43
T609
A
G
D
S
P
V
G
T
T
T
A
T
N
L
E
Site 44
S623
E
Q
P
Q
V
I
P
S
Q
G
D
L
L
G
D
Site 45
S680
V
P
A
T
F
A
P
S
P
T
P
A
V
V
S
Site 46
S726
K
A
K
G
L
E
I
S
G
T
F
T
H
R
Q
Site 47
T728
K
G
L
E
I
S
G
T
F
T
H
R
Q
G
H
Site 48
T730
L
E
I
S
G
T
F
T
H
R
Q
G
H
I
Y
Site 49
Y737
T
H
R
Q
G
H
I
Y
M
E
M
N
F
T
N
Site 50
S761
A
I
Q
F
N
K
N
S
F
G
V
I
P
S
T
Site 51
T768
S
F
G
V
I
P
S
T
P
L
A
I
H
T
P
Site 52
T774
S
T
P
L
A
I
H
T
P
L
M
P
N
Q
S
Site 53
S785
P
N
Q
S
I
D
V
S
L
P
L
N
T
L
G
Site 54
T840
E
R
Q
V
F
L
A
T
W
K
D
I
P
N
E
Site 55
T863
E
C
H
L
N
A
D
T
V
S
S
K
L
Q
N
Site 56
S865
H
L
N
A
D
T
V
S
S
K
L
Q
N
N
N
Site 57
S866
L
N
A
D
T
V
S
S
K
L
Q
N
N
N
V
Site 58
Y874
K
L
Q
N
N
N
V
Y
T
I
A
K
R
N
V
Site 59
T875
L
Q
N
N
N
V
Y
T
I
A
K
R
N
V
E
Site 60
Y888
V
E
G
Q
D
M
L
Y
Q
S
L
K
L
T
N
Site 61
S890
G
Q
D
M
L
Y
Q
S
L
K
L
T
N
G
I
Site 62
Y912
I
Q
P
G
N
P
N
Y
T
L
S
L
K
C
R
Site 63
S915
G
N
P
N
Y
T
L
S
L
K
C
R
A
P
E
Site 64
Y926
R
A
P
E
V
S
Q
Y
I
Y
Q
V
Y
D
S
Site 65
Y928
P
E
V
S
Q
Y
I
Y
Q
V
Y
D
S
I
L
Site 66
Y931
S
Q
Y
I
Y
Q
V
Y
D
S
I
L
K
N
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation