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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
G-alpha-s
Full Name:
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
Alias:
Adenylate cyclase-stimulating G alpha protein; GNAS; GNAS complex locus; GNAS1; GNAS2; GNASXL; GPSA; GSP; guanine nucleotide binding protein (G protein), alpha stimulating activity polypeptide 1; guanine nucleotide-binding protein G; NESP; NESP55; SCG6; secretogranin VI
Type:
G protein, heterotrimeric; G protein
Mass (Da):
45665
Number AA:
394
UniProt ID:
P63092
International Prot ID:
IPI00514055
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005834
GO:0031224
GO:0032588
Uniprot
OncoNet
Molecular Function:
GO:0005525
GO:0003924
GO:0042802
PhosphoSite+
KinaseNET
Biological Process:
GO:0007186
GO:0007190
GO:0009755
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T9
G
C
L
G
N
S
K
T
E
D
Q
R
N
E
E
Site 2
T40
D
K
Q
V
Y
R
A
T
H
R
L
L
L
L
G
Site 3
S54
G
A
G
E
S
G
K
S
T
I
V
K
Q
M
R
Site 4
T55
A
G
E
S
G
K
S
T
I
V
K
Q
M
R
I
Site 5
S82
E
D
P
Q
A
A
R
S
N
S
D
G
E
K
A
Site 6
S84
P
Q
A
A
R
S
N
S
D
G
E
K
A
T
K
Site 7
Y163
D
E
G
V
R
A
C
Y
E
R
S
N
E
Y
Q
Site 8
Y190
D
V
I
K
Q
A
D
Y
V
P
S
D
Q
D
L
Site 9
S193
K
Q
A
D
Y
V
P
S
D
Q
D
L
L
R
C
Site 10
T204
L
L
R
C
R
V
L
T
S
G
I
F
E
T
K
Site 11
T210
L
T
S
G
I
F
E
T
K
F
Q
V
D
K
V
Site 12
T263
V
I
R
E
D
N
Q
T
N
R
L
Q
E
A
L
Site 13
S306
E
K
V
L
A
G
K
S
K
I
E
D
Y
F
P
Site 14
Y311
G
K
S
K
I
E
D
Y
F
P
E
F
A
R
Y
Site 15
Y318
Y
F
P
E
F
A
R
Y
T
T
P
E
D
A
T
Site 16
T319
F
P
E
F
A
R
Y
T
T
P
E
D
A
T
P
Site 17
T320
P
E
F
A
R
Y
T
T
P
E
D
A
T
P
E
Site 18
T325
Y
T
T
P
E
D
A
T
P
E
P
G
E
D
P
Site 19
T335
P
G
E
D
P
R
V
T
R
A
K
Y
F
I
R
Site 20
Y339
P
R
V
T
R
A
K
Y
F
I
R
D
E
F
L
Site 21
S349
R
D
E
F
L
R
I
S
T
A
S
G
D
G
R
Site 22
T350
D
E
F
L
R
I
S
T
A
S
G
D
G
R
H
Site 23
S352
F
L
R
I
S
T
A
S
G
D
G
R
H
Y
C
Site 24
Y358
A
S
G
D
G
R
H
Y
C
Y
P
H
F
T
C
Site 25
Y360
G
D
G
R
H
Y
C
Y
P
H
F
T
C
A
V
Site 26
Y391
Q
R
M
H
L
R
Q
Y
E
L
L
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation