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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
KCNJ2
Full Name:
Inward rectifier potassium channel 2
Alias:
Cardiac inward rectifier potassium channel; HHBIRK1; HHIRK1; HIRK1; Inward rectifier K; IRK1; IRK2; KIR2.1; LQT7; Potassium channel, inwardly rectifying subfamily J member 2; SQT3
Type:
Ion channel, inward rectifier-type potassium channel family
Mass (Da):
48288
Number AA:
427
UniProt ID:
P63252
International Prot ID:
IPI00007614
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005887
Uniprot
OncoNet
Molecular Function:
GO:0005242
GO:0030955
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0006813
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y9
G
S
V
R
T
N
R
Y
S
I
V
S
S
E
E
Site 2
S10
S
V
R
T
N
R
Y
S
I
V
S
S
E
E
D
Site 3
S13
T
N
R
Y
S
I
V
S
S
E
E
D
G
M
K
Site 4
S14
N
R
Y
S
I
V
S
S
E
E
D
G
M
K
L
Site 5
S35
N
G
F
G
N
G
K
S
K
V
H
T
R
Q
Q
Site 6
T39
N
G
K
S
K
V
H
T
R
Q
Q
C
R
S
R
Site 7
S45
H
T
R
Q
Q
C
R
S
R
F
V
K
K
D
G
Site 8
Y68
V
G
E
K
G
Q
R
Y
L
A
D
I
F
T
T
Site 9
S116
L
H
G
D
L
D
A
S
K
E
G
K
A
C
V
Site 10
S124
K
E
G
K
A
C
V
S
E
V
N
S
F
T
A
Site 11
T142
F
S
I
E
T
Q
T
T
I
G
Y
G
F
R
C
Site 12
T192
K
P
K
K
R
N
E
T
L
V
F
S
H
N
A
Site 13
S220
R
V
G
N
L
R
K
S
H
L
V
E
A
H
V
Site 14
S234
V
R
A
Q
L
L
K
S
R
I
T
S
E
G
E
Site 15
T237
Q
L
L
K
S
R
I
T
S
E
G
E
Y
I
P
Site 16
S238
L
L
K
S
R
I
T
S
E
G
E
Y
I
P
L
Site 17
Y242
R
I
T
S
E
G
E
Y
I
P
L
D
Q
I
D
Site 18
S277
V
H
E
I
D
E
D
S
P
L
Y
D
L
S
K
Site 19
Y280
I
D
E
D
S
P
L
Y
D
L
S
K
Q
D
I
Site 20
S283
D
S
P
L
Y
D
L
S
K
Q
D
I
D
N
A
Site 21
T309
V
E
A
T
A
M
T
T
Q
C
R
S
S
Y
L
Site 22
S314
M
T
T
Q
C
R
S
S
Y
L
A
N
E
I
L
Site 23
Y315
T
T
Q
C
R
S
S
Y
L
A
N
E
I
L
W
Site 24
Y326
E
I
L
W
G
H
R
Y
E
P
V
L
F
E
E
Site 25
Y336
V
L
F
E
E
K
H
Y
Y
K
V
D
Y
S
R
Site 26
Y337
L
F
E
E
K
H
Y
Y
K
V
D
Y
S
R
F
Site 27
Y341
K
H
Y
Y
K
V
D
Y
S
R
F
H
K
T
Y
Site 28
S342
H
Y
Y
K
V
D
Y
S
R
F
H
K
T
Y
E
Site 29
Y348
Y
S
R
F
H
K
T
Y
E
V
P
N
T
P
L
Site 30
T353
K
T
Y
E
V
P
N
T
P
L
C
S
A
R
D
Site 31
S357
V
P
N
T
P
L
C
S
A
R
D
L
A
E
K
Site 32
Y366
R
D
L
A
E
K
K
Y
I
L
S
N
A
N
S
Site 33
S390
T
S
K
E
E
D
D
S
E
N
G
V
P
E
S
Site 34
S397
S
E
N
G
V
P
E
S
T
S
T
D
T
P
P
Site 35
T400
G
V
P
E
S
T
S
T
D
T
P
P
D
I
D
Site 36
T402
P
E
S
T
S
T
D
T
P
P
D
I
D
L
H
Site 37
S413
I
D
L
H
N
Q
A
S
V
P
L
E
P
R
P
Site 38
S425
P
R
P
L
R
R
E
S
E
I
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation