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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PPP2CA
Full Name:
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
Alias:
EC 3.1.3.16; PP2AA; PP2A-alpha; PP2Calpha; Protein phosphatase 2 (formerly 2A) catalytic subunit, alpha isoform; Replication protein C; RP-C; Serine/threonine protein phosphatase 2A, catalytic subunit, alpha isoform
Type:
Protein phosphatase, Ser/Thr (non-receptor); EC 3.1.3.16
Mass (Da):
35594
Number AA:
309
UniProt ID:
P67775
International Prot ID:
IPI00008380
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0000775
GO:0005829
GO:0015630
Uniprot
OncoNet
Molecular Function:
GO:0005506
GO:0030145
GO:0004721
PhosphoSite+
KinaseNET
Biological Process:
GO:0008380
GO:0006672
GO:0000188
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S24
L
N
E
C
K
Q
L
S
E
S
Q
V
K
S
L
Site 2
S26
E
C
K
Q
L
S
E
S
Q
V
K
S
L
C
E
Site 3
S30
L
S
E
S
Q
V
K
S
L
C
E
K
A
K
E
Site 4
T53
Q
E
V
R
C
P
V
T
V
C
G
D
V
H
G
Site 5
S75
L
F
R
I
G
G
K
S
P
D
T
N
Y
L
F
Site 6
T78
I
G
G
K
S
P
D
T
N
Y
L
F
M
G
D
Site 7
Y80
G
K
S
P
D
T
N
Y
L
F
M
G
D
Y
V
Site 8
Y86
N
Y
L
F
M
G
D
Y
V
D
R
G
Y
Y
S
Site 9
Y91
G
D
Y
V
D
R
G
Y
Y
S
V
E
T
V
T
Site 10
Y92
D
Y
V
D
R
G
Y
Y
S
V
E
T
V
T
L
Site 11
T112
V
R
Y
R
E
R
I
T
I
L
R
G
N
H
E
Site 12
S120
I
L
R
G
N
H
E
S
R
Q
I
T
Q
V
Y
Site 13
T124
N
H
E
S
R
Q
I
T
Q
V
Y
G
F
Y
D
Site 14
Y127
S
R
Q
I
T
Q
V
Y
G
F
Y
D
E
C
L
Site 15
Y137
Y
D
E
C
L
R
K
Y
G
N
A
N
V
W
K
Site 16
Y145
G
N
A
N
V
W
K
Y
F
T
D
L
F
D
Y
Site 17
S201
P
M
C
D
L
L
W
S
D
P
D
D
R
G
G
Site 18
S212
D
R
G
G
W
G
I
S
P
R
G
A
G
Y
T
Site 19
T219
S
P
R
G
A
G
Y
T
F
G
Q
D
I
S
E
Site 20
T227
F
G
Q
D
I
S
E
T
F
N
H
A
N
G
L
Site 21
T235
F
N
H
A
N
G
L
T
L
V
S
R
A
H
Q
Site 22
Y248
H
Q
L
V
M
E
G
Y
N
W
C
H
D
R
N
Site 23
Y265
T
I
F
S
A
P
N
Y
C
Y
R
C
G
N
Q
Site 24
Y284
E
L
D
D
T
L
K
Y
S
F
L
Q
F
D
P
Site 25
S285
L
D
D
T
L
K
Y
S
F
L
Q
F
D
P
A
Site 26
T301
R
R
G
E
P
H
V
T
R
R
T
P
D
Y
F
Site 27
T304
E
P
H
V
T
R
R
T
P
D
Y
F
L
_
_
Site 28
Y307
V
T
R
R
T
P
D
Y
F
L
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation