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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TUBA4A
Full Name:
Tubulin alpha-4A chain
Alias:
Alpha-tubulin 1; FLJ30169; H2-ALPHA; TBA1; TBA1A; TBA4A; Testis-specific alpha- tubulin; TUBA1; Tubulin alpha-1 chain; Tubulin H2-alpha; Tubulin, alpha 4a; Tubulin, alpha-4A
Type:
Cytoskeletal protein - Microtubule dynamics
Mass (Da):
49924
Number AA:
448
UniProt ID:
P68366
International Prot ID:
IPI00007750
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
GO:0005576
GO:0005874
Uniprot
OncoNet
Molecular Function:
GO:0005525
GO:0003924
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0007018
GO:0051258
GO:0007017
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S38
Q
P
D
G
Q
M
P
S
D
K
T
I
G
G
G
Site 2
T41
G
Q
M
P
S
D
K
T
I
G
G
G
D
D
S
Site 3
S48
T
I
G
G
G
D
D
S
F
T
T
F
F
C
E
Site 4
T50
G
G
G
D
D
S
F
T
T
F
F
C
E
T
G
Site 5
T51
G
G
D
D
S
F
T
T
F
F
C
E
T
G
A
Site 6
T73
V
F
V
D
L
E
P
T
V
I
D
E
I
R
N
Site 7
T94
F
H
P
E
Q
L
I
T
G
K
E
D
A
A
N
Site 8
Y103
K
E
D
A
A
N
N
Y
A
R
G
H
Y
T
I
Site 9
Y108
N
N
Y
A
R
G
H
Y
T
I
G
K
E
I
I
Site 10
T109
N
Y
A
R
G
H
Y
T
I
G
K
E
I
I
D
Site 11
S126
L
D
R
I
R
K
L
S
D
Q
C
T
G
L
Q
Site 12
T130
R
K
L
S
D
Q
C
T
G
L
Q
G
F
L
V
Site 13
S158
S
L
L
M
E
R
L
S
V
D
Y
G
K
K
S
Site 14
Y161
M
E
R
L
S
V
D
Y
G
K
K
S
K
L
E
Site 15
S165
S
V
D
Y
G
K
K
S
K
L
E
F
S
I
Y
Site 16
Y172
S
K
L
E
F
S
I
Y
P
A
P
Q
V
S
T
Site 17
Y185
S
T
A
V
V
E
P
Y
N
S
I
L
T
T
H
Site 18
S187
A
V
V
E
P
Y
N
S
I
L
T
T
H
T
T
Site 19
T190
E
P
Y
N
S
I
L
T
T
H
T
T
L
E
H
Site 20
T191
P
Y
N
S
I
L
T
T
H
T
T
L
E
H
S
Site 21
T193
N
S
I
L
T
T
H
T
T
L
E
H
S
D
C
Site 22
T194
S
I
L
T
T
H
T
T
L
E
H
S
D
C
A
Site 23
S198
T
H
T
T
L
E
H
S
D
C
A
F
M
V
D
Site 24
Y210
M
V
D
N
E
A
I
Y
D
I
C
R
R
N
L
Site 25
T223
N
L
D
I
E
R
P
T
Y
T
N
L
N
R
L
Site 26
Y224
L
D
I
E
R
P
T
Y
T
N
L
N
R
L
I
Site 27
T225
D
I
E
R
P
T
Y
T
N
L
N
R
L
I
S
Site 28
S232
T
N
L
N
R
L
I
S
Q
I
V
S
S
I
T
Site 29
S236
R
L
I
S
Q
I
V
S
S
I
T
A
S
L
R
Site 30
S237
L
I
S
Q
I
V
S
S
I
T
A
S
L
R
F
Site 31
T239
S
Q
I
V
S
S
I
T
A
S
L
R
F
D
G
Site 32
S241
I
V
S
S
I
T
A
S
L
R
F
D
G
A
L
Site 33
Y262
F
Q
T
N
L
V
P
Y
P
R
I
H
F
P
L
Site 34
T271
R
I
H
F
P
L
A
T
Y
A
P
V
I
S
A
Site 35
Y272
I
H
F
P
L
A
T
Y
A
P
V
I
S
A
E
Site 36
S277
A
T
Y
A
P
V
I
S
A
E
K
A
Y
H
E
Site 37
Y282
V
I
S
A
E
K
A
Y
H
E
Q
L
S
V
A
Site 38
S287
K
A
Y
H
E
Q
L
S
V
A
E
I
T
N
A
Site 39
T292
Q
L
S
V
A
E
I
T
N
A
C
F
E
P
A
Site 40
Y312
C
D
P
R
H
G
K
Y
M
A
C
C
L
L
Y
Site 41
Y319
Y
M
A
C
C
L
L
Y
R
G
D
V
V
P
K
Site 42
S340
A
A
I
K
T
K
R
S
I
Q
F
V
D
W
C
Site 43
T349
Q
F
V
D
W
C
P
T
G
F
K
V
G
I
N
Site 44
Y357
G
F
K
V
G
I
N
Y
Q
P
P
T
V
V
P
Site 45
T361
G
I
N
Y
Q
P
P
T
V
V
P
G
G
D
L
Site 46
S379
Q
R
A
V
C
M
L
S
N
T
T
A
I
A
E
Site 47
Y399
D
H
K
F
D
L
M
Y
A
K
R
A
F
V
H
Site 48
Y408
K
R
A
F
V
H
W
Y
V
G
E
G
M
E
E
Site 49
S419
G
M
E
E
G
E
F
S
E
A
R
E
D
M
A
Site 50
Y432
M
A
A
L
E
K
D
Y
E
E
V
G
I
D
S
Site 51
S439
Y
E
E
V
G
I
D
S
Y
E
D
E
D
E
G
Site 52
Y440
E
E
V
G
I
D
S
Y
E
D
E
D
E
G
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation