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Updated November 2019
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Protein Info
Short Name:
RES4-22D
Full Name:
Protein FAM193A
Alias:
RES4-22
Type:
Uncharacterized protein
Mass (Da):
139988
Number AA:
944
UniProt ID:
P78312
International Prot ID:
IPI00181821
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S32
P
Q
A
H
Q
F
I
S
L
L
L
E
E
Y
G
Site 2
T50
Q
A
A
R
S
I
S
T
F
L
G
T
L
E
N
Site 3
T66
H
L
K
K
F
Q
V
T
W
E
L
H
N
K
H
Site 4
T100
V
S
Q
I
R
L
G
T
T
T
H
D
T
C
S
Site 5
T102
Q
I
R
L
G
T
T
T
H
D
T
C
S
E
D
Site 6
T105
L
G
T
T
T
H
D
T
C
S
E
D
T
Y
S
Site 7
S107
T
T
T
H
D
T
C
S
E
D
T
Y
S
T
L
Site 8
T110
H
D
T
C
S
E
D
T
Y
S
T
L
L
Q
R
Site 9
Y111
D
T
C
S
E
D
T
Y
S
T
L
L
Q
R
Y
Site 10
S112
T
C
S
E
D
T
Y
S
T
L
L
Q
R
Y
Q
Site 11
Y118
Y
S
T
L
L
Q
R
Y
Q
R
S
E
E
E
L
Site 12
S121
L
L
Q
R
Y
Q
R
S
E
E
E
L
R
R
V
Site 13
Y142
C
Q
K
R
I
D
A
Y
V
D
E
Q
M
T
M
Site 14
T151
D
E
Q
M
T
M
K
T
K
Q
R
M
L
T
E
Site 15
T157
K
T
K
Q
R
M
L
T
E
D
W
E
L
F
K
Site 16
T174
R
F
I
E
E
Q
L
T
N
K
K
A
V
T
G
Site 17
T188
G
E
N
N
F
T
D
T
M
R
H
M
L
S
S
Site 18
S194
D
T
M
R
H
M
L
S
S
R
L
S
M
P
D
Site 19
S195
T
M
R
H
M
L
S
S
R
L
S
M
P
D
C
Site 20
S198
H
M
L
S
S
R
L
S
M
P
D
C
P
N
C
Site 21
Y250
Q
V
D
P
A
P
D
Y
L
A
E
R
S
P
P
Site 22
S255
P
D
Y
L
A
E
R
S
P
P
S
V
S
S
A
Site 23
S258
L
A
E
R
S
P
P
S
V
S
S
A
S
S
G
Site 24
S260
E
R
S
P
P
S
V
S
S
A
S
S
G
S
G
Site 25
S261
R
S
P
P
S
V
S
S
A
S
S
G
S
G
S
Site 26
S263
P
P
S
V
S
S
A
S
S
G
S
G
S
S
S
Site 27
S264
P
S
V
S
S
A
S
S
G
S
G
S
S
S
P
Site 28
S266
V
S
S
A
S
S
G
S
G
S
S
S
P
I
T
Site 29
S268
S
A
S
S
G
S
G
S
S
S
P
I
T
I
Q
Site 30
S270
S
S
G
S
G
S
S
S
P
I
T
I
Q
Q
H
Site 31
T273
S
G
S
S
S
P
I
T
I
Q
Q
H
P
R
L
Site 32
T283
Q
H
P
R
L
I
L
T
D
S
G
S
A
P
T
Site 33
S287
L
I
L
T
D
S
G
S
A
P
T
F
C
S
D
Site 34
T290
T
D
S
G
S
A
P
T
F
C
S
D
D
E
D
Site 35
S293
G
S
A
P
T
F
C
S
D
D
E
D
V
A
P
Site 36
S302
D
E
D
V
A
P
L
S
A
K
F
A
D
I
Y
Site 37
Y309
S
A
K
F
A
D
I
Y
P
L
S
N
Y
D
D
Site 38
S312
F
A
D
I
Y
P
L
S
N
Y
D
D
T
E
V
Site 39
Y314
D
I
Y
P
L
S
N
Y
D
D
T
E
V
V
A
Site 40
T317
P
L
S
N
Y
D
D
T
E
V
V
A
N
M
N
Site 41
S328
A
N
M
N
G
I
H
S
E
L
N
G
G
G
E
Site 42
S343
N
M
A
L
K
D
E
S
P
Q
I
S
S
T
S
Site 43
S347
K
D
E
S
P
Q
I
S
S
T
S
S
S
S
S
Site 44
S348
D
E
S
P
Q
I
S
S
T
S
S
S
S
S
E
Site 45
T349
E
S
P
Q
I
S
S
T
S
S
S
S
S
E
A
Site 46
S350
S
P
Q
I
S
S
T
S
S
S
S
S
E
A
D
Site 47
S351
P
Q
I
S
S
T
S
S
S
S
S
E
A
D
D
Site 48
S352
Q
I
S
S
T
S
S
S
S
S
E
A
D
D
E
Site 49
S354
S
S
T
S
S
S
S
S
E
A
D
D
E
E
A
Site 50
S381
K
E
D
G
V
L
G
S
R
S
P
R
T
E
E
Site 51
S383
D
G
V
L
G
S
R
S
P
R
T
E
E
S
K
Site 52
T386
L
G
S
R
S
P
R
T
E
E
S
K
A
D
S
Site 53
S389
R
S
P
R
T
E
E
S
K
A
D
S
P
P
P
Site 54
S393
T
E
E
S
K
A
D
S
P
P
P
S
Y
P
T
Site 55
S397
K
A
D
S
P
P
P
S
Y
P
T
Q
Q
A
E
Site 56
Y398
A
D
S
P
P
P
S
Y
P
T
Q
Q
A
E
Q
Site 57
T423
K
Q
E
A
S
G
L
T
P
S
A
M
T
A
G
Site 58
S440
P
P
G
H
Q
F
L
S
P
E
K
P
T
H
P
Site 59
Y452
T
H
P
A
L
H
L
Y
P
H
I
H
G
H
V
Site 60
T463
H
G
H
V
P
L
H
T
V
P
H
L
P
R
P
Site 61
T475
P
R
P
L
I
H
P
T
L
Y
A
T
P
P
F
Site 62
Y477
P
L
I
H
P
T
L
Y
A
T
P
P
F
T
H
Site 63
T479
I
H
P
T
L
Y
A
T
P
P
F
T
H
S
K
Site 64
T483
L
Y
A
T
P
P
F
T
H
S
K
A
L
P
P
Site 65
S485
A
T
P
P
F
T
H
S
K
A
L
P
P
A
P
Site 66
Y512
A
S
L
Q
D
H
I
Y
P
S
C
F
G
N
T
Site 67
T519
Y
P
S
C
F
G
N
T
P
E
W
N
S
S
K
Site 68
T545
D
K
N
W
N
P
G
T
F
L
P
D
T
I
S
Site 69
S562
E
I
L
G
P
T
L
S
E
T
R
P
E
A
L
Site 70
S573
P
E
A
L
P
P
P
S
S
N
E
T
P
A
V
Site 71
S574
E
A
L
P
P
P
S
S
N
E
T
P
A
V
S
Site 72
T577
P
P
P
S
S
N
E
T
P
A
V
S
D
S
K
Site 73
S581
S
N
E
T
P
A
V
S
D
S
K
E
K
K
N
Site 74
S583
E
T
P
A
V
S
D
S
K
E
K
K
N
A
A
Site 75
Y596
A
A
K
K
K
C
L
Y
N
F
Q
D
A
F
M
Site 76
S620
S
S
A
T
S
S
V
S
C
T
A
T
T
V
Q
Site 77
T622
A
T
S
S
V
S
C
T
A
T
T
V
Q
S
S
Site 78
T624
S
S
V
S
C
T
A
T
T
V
Q
S
S
N
S
Site 79
T625
S
V
S
C
T
A
T
T
V
Q
S
S
N
S
Q
Site 80
S631
T
T
V
Q
S
S
N
S
Q
F
R
V
S
S
K
Site 81
S636
S
N
S
Q
F
R
V
S
S
K
R
P
P
S
V
Site 82
S637
N
S
Q
F
R
V
S
S
K
R
P
P
S
V
G
Site 83
S642
V
S
S
K
R
P
P
S
V
G
D
V
F
H
G
Site 84
S658
S
K
E
D
H
R
H
S
A
P
A
A
P
R
N
Site 85
S666
A
P
A
A
P
R
N
S
P
T
G
L
A
P
L
Site 86
S677
L
A
P
L
P
A
L
S
P
A
A
L
S
P
A
Site 87
S682
A
L
S
P
A
A
L
S
P
A
A
L
S
P
A
Site 88
T705
A
A
P
S
F
P
K
T
A
T
T
T
P
G
F
Site 89
T707
P
S
F
P
K
T
A
T
T
T
P
G
F
V
D
Site 90
T709
F
P
K
T
A
T
T
T
P
G
F
V
D
T
R
Site 91
S718
G
F
V
D
T
R
K
S
F
C
P
A
P
L
P
Site 92
T728
P
A
P
L
P
P
A
T
D
G
S
I
S
A
P
Site 93
S731
L
P
P
A
T
D
G
S
I
S
A
P
P
S
V
Site 94
S733
P
A
T
D
G
S
I
S
A
P
P
S
V
C
S
Site 95
S737
G
S
I
S
A
P
P
S
V
C
S
D
P
D
C
Site 96
S740
S
A
P
P
S
V
C
S
D
P
D
C
E
G
H
Site 97
Y754
H
R
C
E
N
G
V
Y
D
P
Q
Q
D
D
G
Site 98
S764
Q
Q
D
D
G
D
E
S
A
D
E
D
S
C
S
Site 99
S769
D
E
S
A
D
E
D
S
C
S
E
H
S
S
S
Site 100
S771
S
A
D
E
D
S
C
S
E
H
S
S
S
T
S
Site 101
S774
E
D
S
C
S
E
H
S
S
S
T
S
T
S
T
Site 102
S775
D
S
C
S
E
H
S
S
S
T
S
T
S
T
N
Site 103
S776
S
C
S
E
H
S
S
S
T
S
T
S
T
N
Q
Site 104
S778
S
E
H
S
S
S
T
S
T
S
T
N
Q
K
E
Site 105
T779
E
H
S
S
S
T
S
T
S
T
N
Q
K
E
G
Site 106
S780
H
S
S
S
T
S
T
S
T
N
Q
K
E
G
K
Site 107
T807
G
G
P
P
A
A
P
T
S
R
N
Y
A
E
M
Site 108
S808
G
P
P
A
A
P
T
S
R
N
Y
A
E
M
R
Site 109
Y811
A
A
P
T
S
R
N
Y
A
E
M
R
E
K
L
Site 110
T823
E
K
L
R
L
R
L
T
K
R
K
E
E
Q
P
Site 111
S837
P
K
K
M
D
Q
I
S
E
R
E
S
V
V
D
Site 112
S841
D
Q
I
S
E
R
E
S
V
V
D
H
R
R
V
Site 113
S857
D
L
L
Q
F
I
N
S
S
E
T
K
P
V
S
Site 114
S858
L
L
Q
F
I
N
S
S
E
T
K
P
V
S
S
Site 115
S864
S
S
E
T
K
P
V
S
S
T
R
A
A
K
R
Site 116
S865
S
E
T
K
P
V
S
S
T
R
A
A
K
R
A
Site 117
S942
K
K
K
K
E
R
P
S
K
D
C
P
K
L
D
Site 118
S961
N
F
Q
A
A
T
E
S
V
P
N
S
G
N
I
Site 119
S965
A
T
E
S
V
P
N
S
G
N
I
H
N
G
S
Site 120
S972
S
G
N
I
H
N
G
S
L
E
Q
T
E
E
P
Site 121
T976
H
N
G
S
L
E
Q
T
E
E
P
E
T
S
S
Site 122
T981
E
Q
T
E
E
P
E
T
S
S
H
S
P
S
R
Site 123
S982
Q
T
E
E
P
E
T
S
S
H
S
P
S
R
H
Site 124
S983
T
E
E
P
E
T
S
S
H
S
P
S
R
H
M
Site 125
S985
E
P
E
T
S
S
H
S
P
S
R
H
M
N
H
Site 126
S987
E
T
S
S
H
S
P
S
R
H
M
N
H
S
E
Site 127
S993
P
S
R
H
M
N
H
S
E
P
R
P
G
L
G
Site 128
S1014
D
P
V
D
T
R
D
S
K
F
L
L
P
K
E
Site 129
T1052
G
K
Q
K
L
R
Q
T
S
K
A
S
S
E
P
Site 130
S1053
K
Q
K
L
R
Q
T
S
K
A
S
S
E
P
A
Site 131
S1057
R
Q
T
S
K
A
S
S
E
P
A
R
R
P
T
Site 132
T1064
S
E
P
A
R
R
P
T
E
P
P
K
A
T
E
Site 133
T1080
Q
S
K
P
R
A
Q
T
E
S
K
A
K
V
V
Site 134
S1082
K
P
R
A
Q
T
E
S
K
A
K
V
V
D
L
Site 135
S1091
A
K
V
V
D
L
M
S
I
T
E
Q
K
R
E
Site 136
S1120
N
H
I
K
D
E
K
S
N
P
T
P
M
E
P
Site 137
T1123
K
D
E
K
S
N
P
T
P
M
E
P
T
S
P
Site 138
S1129
P
T
P
M
E
P
T
S
P
G
E
H
Q
Q
N
Site 139
S1144
S
K
L
V
L
A
E
S
P
Q
P
K
G
K
N
Site 140
S1165
K
G
D
R
V
N
N
S
I
D
G
V
S
L
L
Site 141
S1193
C
N
L
R
L
P
G
S
S
D
C
A
A
S
A
Site 142
S1194
N
L
R
L
P
G
S
S
D
C
A
A
S
A
S
Site 143
S1220
P
K
D
I
D
L
D
S
V
D
M
D
E
T
E
Site 144
T1226
D
S
V
D
M
D
E
T
E
R
E
V
E
Y
F
Site 145
Y1232
E
T
E
R
E
V
E
Y
F
K
R
F
C
L
D
Site 146
S1240
F
K
R
F
C
L
D
S
A
R
Q
T
R
Q
R
Site 147
T1244
C
L
D
S
A
R
Q
T
R
Q
R
L
S
I
N
Site 148
S1249
R
Q
T
R
Q
R
L
S
I
N
W
S
N
F
S
Site 149
S1253
Q
R
L
S
I
N
W
S
N
F
S
L
K
K
A
Site 150
S1256
S
I
N
W
S
N
F
S
L
K
K
A
T
F
A
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation