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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
3BP2
Full Name:
SH3 domain-binding protein 2
Alias:
3BP-2; CRBM; RES4-23; SH3BP2; SH3-domain binding protein 2
Type:
Adapter/scaffold protein
Mass (Da):
62244
Number AA:
561
UniProt ID:
P78314
International Prot ID:
IPI00783201
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0017124
GO:0005070
PhosphoSite+
KinaseNET
Biological Process:
GO:0007165
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y32
G
G
V
A
K
A
G
Y
L
H
K
K
G
G
T
Site 2
T39
Y
L
H
K
K
G
G
T
Q
L
Q
L
L
K
W
Site 3
Y59
I
I
H
K
R
C
V
Y
Y
F
K
S
S
T
S
Site 4
Y60
I
H
K
R
C
V
Y
Y
F
K
S
S
T
S
A
Site 5
S63
R
C
V
Y
Y
F
K
S
S
T
S
A
S
P
Q
Site 6
S64
C
V
Y
Y
F
K
S
S
T
S
A
S
P
Q
G
Site 7
S66
Y
Y
F
K
S
S
T
S
A
S
P
Q
G
A
F
Site 8
S68
F
K
S
S
T
S
A
S
P
Q
G
A
F
S
L
Site 9
S74
A
S
P
Q
G
A
F
S
L
S
G
Y
N
R
V
Site 10
S76
P
Q
G
A
F
S
L
S
G
Y
N
R
V
M
R
Site 11
Y78
G
A
F
S
L
S
G
Y
N
R
V
M
R
A
A
Site 12
T88
V
M
R
A
A
E
E
T
T
S
N
N
V
F
P
Site 13
S90
R
A
A
E
E
T
T
S
N
N
V
F
P
F
K
Site 14
T107
H
I
S
K
K
H
R
T
W
F
F
S
A
S
S
Site 15
S111
K
H
R
T
W
F
F
S
A
S
S
E
E
E
R
Site 16
S113
R
T
W
F
F
S
A
S
S
E
E
E
R
K
S
Site 17
S114
T
W
F
F
S
A
S
S
E
E
E
R
K
S
W
Site 18
S120
S
S
E
E
E
R
K
S
W
M
A
L
L
R
R
Site 19
T142
K
K
D
L
P
L
D
T
S
D
S
S
S
D
T
Site 20
S143
K
D
L
P
L
D
T
S
D
S
S
S
D
T
D
Site 21
S145
L
P
L
D
T
S
D
S
S
S
D
T
D
S
F
Site 22
S146
P
L
D
T
S
D
S
S
S
D
T
D
S
F
Y
Site 23
S147
L
D
T
S
D
S
S
S
D
T
D
S
F
Y
G
Site 24
T149
T
S
D
S
S
S
D
T
D
S
F
Y
G
A
V
Site 25
S151
D
S
S
S
D
T
D
S
F
Y
G
A
V
E
R
Site 26
Y153
S
S
D
T
D
S
F
Y
G
A
V
E
R
P
V
Site 27
S163
V
E
R
P
V
D
I
S
L
S
P
Y
P
T
D
Site 28
S165
R
P
V
D
I
S
L
S
P
Y
P
T
D
N
E
Site 29
Y167
V
D
I
S
L
S
P
Y
P
T
D
N
E
D
Y
Site 30
T169
I
S
L
S
P
Y
P
T
D
N
E
D
Y
E
H
Site 31
Y174
Y
P
T
D
N
E
D
Y
E
H
D
D
E
D
D
Site 32
S182
E
H
D
D
E
D
D
S
Y
L
E
P
D
S
P
Site 33
Y183
H
D
D
E
D
D
S
Y
L
E
P
D
S
P
E
Site 34
S188
D
S
Y
L
E
P
D
S
P
E
P
G
R
L
E
Site 35
Y204
A
L
M
H
P
P
A
Y
P
P
P
P
V
P
T
Site 36
T211
Y
P
P
P
P
V
P
T
P
R
K
P
A
F
S
Site 37
S218
T
P
R
K
P
A
F
S
D
M
P
R
A
H
S
Site 38
S225
S
D
M
P
R
A
H
S
F
T
S
K
G
P
G
Site 39
T227
M
P
R
A
H
S
F
T
S
K
G
P
G
P
L
Site 40
S228
P
R
A
H
S
F
T
S
K
G
P
G
P
L
L
Site 41
S254
V
G
L
A
A
E
D
S
K
R
D
P
L
C
P
Site 42
T273
P
C
P
R
V
P
A
T
P
R
R
M
S
D
P
Site 43
S278
P
A
T
P
R
R
M
S
D
P
P
L
S
T
M
Site 44
S283
R
M
S
D
P
P
L
S
T
M
P
T
A
P
G
Site 45
T287
P
P
L
S
T
M
P
T
A
P
G
L
R
K
P
Site 46
S300
K
P
P
C
F
R
E
S
A
S
P
S
P
E
P
Site 47
S302
P
C
F
R
E
S
A
S
P
S
P
E
P
W
T
Site 48
S304
F
R
E
S
A
S
P
S
P
E
P
W
T
P
G
Site 49
T309
S
P
S
P
E
P
W
T
P
G
H
G
A
C
S
Site 50
S336
R
N
C
D
K
L
K
S
F
H
L
S
P
R
G
Site 51
S340
K
L
K
S
F
H
L
S
P
R
G
P
P
T
S
Site 52
T346
L
S
P
R
G
P
P
T
S
E
P
P
P
V
P
Site 53
S347
S
P
R
G
P
P
T
S
E
P
P
P
V
P
A
Site 54
S416
Q
L
P
H
L
Q
R
S
P
P
D
G
Q
S
F
Site 55
S422
R
S
P
P
D
G
Q
S
F
R
S
F
S
F
E
Site 56
S425
P
D
G
Q
S
F
R
S
F
S
F
E
K
P
R
Site 57
S427
G
Q
S
F
R
S
F
S
F
E
K
P
R
Q
P
Site 58
S435
F
E
K
P
R
Q
P
S
Q
A
D
T
G
G
D
Site 59
T439
R
Q
P
S
Q
A
D
T
G
G
D
D
S
D
E
Site 60
S444
A
D
T
G
G
D
D
S
D
E
D
Y
E
K
V
Site 61
Y448
G
D
D
S
D
E
D
Y
E
K
V
P
L
P
N
Site 62
S456
E
K
V
P
L
P
N
S
V
F
V
N
T
T
E
Site 63
T474
V
E
R
L
F
K
A
T
S
P
R
G
E
P
Q
Site 64
S475
E
R
L
F
K
A
T
S
P
R
G
E
P
Q
D
Site 65
Y485
G
E
P
Q
D
G
L
Y
C
I
R
N
S
S
T
Site 66
S490
G
L
Y
C
I
R
N
S
S
T
K
S
G
K
V
Site 67
S491
L
Y
C
I
R
N
S
S
T
K
S
G
K
V
L
Site 68
S494
I
R
N
S
S
T
K
S
G
K
V
L
V
V
W
Site 69
T504
V
L
V
V
W
D
E
T
S
N
K
V
R
N
Y
Site 70
Y511
T
S
N
K
V
R
N
Y
R
I
F
E
K
D
S
Site 71
Y538
V
G
S
M
V
E
H
Y
H
T
H
V
L
P
S
Site 72
T540
S
M
V
E
H
Y
H
T
H
V
L
P
S
H
Q
Site 73
S545
Y
H
T
H
V
L
P
S
H
Q
S
L
L
L
R
Site 74
S548
H
V
L
P
S
H
Q
S
L
L
L
R
H
P
Y
Site 75
Y555
S
L
L
L
R
H
P
Y
G
Y
T
G
P
R
_
Site 76
Y557
L
L
R
H
P
Y
G
Y
T
G
P
R
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation