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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
RBM6
Full Name:
RNA-binding protein 6
Alias:
3G2; DEF3; DEF-3; G16; Lung cancer antigen NY-LU-12; NY-LU-12; RNA binding motif protein 6; RNA-binding motif protein 6; RNA-binding protein DEF-3
Type:
RNA binding protein
Mass (Da):
128644
Number AA:
1123
UniProt ID:
P78332
International Prot ID:
IPI00297723
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0003677
GO:0003723
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0006396
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T11
D
S
R
P
A
N
R
T
G
P
F
R
G
S
Q
Site 2
S17
R
T
G
P
F
R
G
S
Q
E
E
R
F
A
P
Site 3
Y30
A
P
G
W
N
R
D
Y
P
P
P
P
L
K
S
Site 4
S37
Y
P
P
P
P
L
K
S
H
A
Q
E
R
H
S
Site 5
S44
S
H
A
Q
E
R
H
S
G
N
F
P
G
R
D
Site 6
S52
G
N
F
P
G
R
D
S
L
P
F
D
F
Q
G
Site 7
S61
P
F
D
F
Q
G
H
S
G
P
P
F
A
N
V
Site 8
S72
F
A
N
V
E
E
H
S
F
S
Y
G
A
R
D
Site 9
S74
N
V
E
E
H
S
F
S
Y
G
A
R
D
G
P
Site 10
Y75
V
E
E
H
S
F
S
Y
G
A
R
D
G
P
H
Site 11
Y85
R
D
G
P
H
G
D
Y
R
G
G
E
G
P
G
Site 12
S101
D
F
R
G
G
D
F
S
S
S
D
F
Q
S
R
Site 13
S102
F
R
G
G
D
F
S
S
S
D
F
Q
S
R
D
Site 14
S103
R
G
G
D
F
S
S
S
D
F
Q
S
R
D
S
Site 15
S107
F
S
S
S
D
F
Q
S
R
D
S
S
Q
L
D
Site 16
S110
S
D
F
Q
S
R
D
S
S
Q
L
D
F
R
G
Site 17
S111
D
F
Q
S
R
D
S
S
Q
L
D
F
R
G
R
Site 18
Y135
R
E
G
P
P
M
D
Y
R
G
G
D
G
T
S
Site 19
T141
D
Y
R
G
G
D
G
T
S
M
D
Y
R
G
R
Site 20
S142
Y
R
G
G
D
G
T
S
M
D
Y
R
G
R
E
Site 21
Y145
G
D
G
T
S
M
D
Y
R
G
R
E
A
P
H
Site 22
Y155
R
E
A
P
H
M
N
Y
R
D
R
D
A
H
A
Site 23
S173
R
G
R
D
A
P
P
S
D
F
R
G
R
G
T
Site 24
T180
S
D
F
R
G
R
G
T
Y
D
L
D
F
R
G
Site 25
Y181
D
F
R
G
R
G
T
Y
D
L
D
F
R
G
R
Site 26
S191
D
F
R
G
R
D
G
S
H
A
D
F
R
G
R
Site 27
S201
D
F
R
G
R
D
L
S
D
L
D
F
R
A
R
Site 28
S211
D
F
R
A
R
E
Q
S
R
S
D
F
R
N
R
Site 29
S213
R
A
R
E
Q
S
R
S
D
F
R
N
R
D
V
Site 30
S221
D
F
R
N
R
D
V
S
D
L
D
F
R
D
K
Site 31
T231
D
F
R
D
K
D
G
T
Q
V
D
F
R
G
R
Site 32
S240
V
D
F
R
G
R
G
S
G
T
T
D
L
D
F
Site 33
T243
R
G
R
G
S
G
T
T
D
L
D
F
R
D
R
Site 34
T252
L
D
F
R
D
R
D
T
P
H
S
D
F
R
G
Site 35
S255
R
D
R
D
T
P
H
S
D
F
R
G
R
H
R
Site 36
S263
D
F
R
G
R
H
R
S
R
T
D
Q
D
F
R
Site 37
T265
R
G
R
H
R
S
R
T
D
Q
D
F
R
G
R
Site 38
Y295
V
D
P
N
I
L
D
Y
I
Q
P
S
T
Q
D
Site 39
S299
I
L
D
Y
I
Q
P
S
T
Q
D
R
E
H
S
Site 40
T300
L
D
Y
I
Q
P
S
T
Q
D
R
E
H
S
G
Site 41
S306
S
T
Q
D
R
E
H
S
G
M
N
V
N
R
R
Site 42
S316
N
V
N
R
R
E
E
S
T
H
D
H
T
I
E
Site 43
T317
V
N
R
R
E
E
S
T
H
D
H
T
I
E
R
Site 44
T321
E
E
S
T
H
D
H
T
I
E
R
P
A
F
G
Site 45
S337
Q
K
G
E
F
E
H
S
E
T
R
E
G
E
T
Site 46
T339
G
E
F
E
H
S
E
T
R
E
G
E
T
Q
G
Site 47
T344
S
E
T
R
E
G
E
T
Q
G
V
A
F
E
H
Site 48
S353
G
V
A
F
E
H
E
S
P
A
D
F
Q
N
S
Site 49
S360
S
P
A
D
F
Q
N
S
Q
S
P
V
Q
D
Q
Site 50
S362
A
D
F
Q
N
S
Q
S
P
V
Q
D
Q
D
K
Site 51
S370
P
V
Q
D
Q
D
K
S
Q
L
S
G
R
E
E
Site 52
S373
D
Q
D
K
S
Q
L
S
G
R
E
E
Q
S
S
Site 53
S379
L
S
G
R
E
E
Q
S
S
D
A
G
L
F
K
Site 54
S380
S
G
R
E
E
Q
S
S
D
A
G
L
F
K
E
Site 55
T399
D
F
L
G
R
Q
D
T
D
Y
R
S
M
E
Y
Site 56
Y401
L
G
R
Q
D
T
D
Y
R
S
M
E
Y
R
D
Site 57
S403
R
Q
D
T
D
Y
R
S
M
E
Y
R
D
V
D
Site 58
S416
V
D
H
R
L
P
G
S
Q
M
F
G
Y
G
Q
Site 59
Y421
P
G
S
Q
M
F
G
Y
G
Q
S
K
S
F
P
Site 60
S424
Q
M
F
G
Y
G
Q
S
K
S
F
P
E
G
K
Site 61
S426
F
G
Y
G
Q
S
K
S
F
P
E
G
K
T
A
Site 62
T432
K
S
F
P
E
G
K
T
A
R
D
A
Q
R
D
Site 63
Y445
R
D
L
Q
D
Q
D
Y
R
T
G
P
S
E
E
Site 64
T447
L
Q
D
Q
D
Y
R
T
G
P
S
E
E
K
P
Site 65
S450
Q
D
Y
R
T
G
P
S
E
E
K
P
S
R
L
Site 66
S455
G
P
S
E
E
K
P
S
R
L
I
R
L
S
G
Site 67
S461
P
S
R
L
I
R
L
S
G
V
P
E
D
A
T
Site 68
T468
S
G
V
P
E
D
A
T
K
E
E
I
L
N
A
Site 69
T478
E
I
L
N
A
F
R
T
P
D
G
M
P
V
K
Site 70
Y492
K
N
L
Q
L
K
E
Y
N
T
G
Y
D
Y
G
Site 71
Y496
L
K
E
Y
N
T
G
Y
D
Y
G
Y
V
C
V
Site 72
Y498
E
Y
N
T
G
Y
D
Y
G
Y
V
C
V
E
F
Site 73
Y500
N
T
G
Y
D
Y
G
Y
V
C
V
E
F
S
L
Site 74
Y533
D
K
E
V
T
L
E
Y
V
S
S
L
D
F
W
Site 75
Y541
V
S
S
L
D
F
W
Y
C
K
R
C
K
A
N
Site 76
S554
A
N
I
G
G
H
R
S
S
C
S
F
C
K
N
Site 77
S555
N
I
G
G
H
R
S
S
C
S
F
C
K
N
P
Site 78
S557
G
G
H
R
S
S
C
S
F
C
K
N
P
R
E
Site 79
T566
C
K
N
P
R
E
V
T
E
A
K
Q
E
L
I
Site 80
Y575
A
K
Q
E
L
I
T
Y
P
Q
P
Q
K
T
S
Site 81
T581
T
Y
P
Q
P
Q
K
T
S
I
P
A
P
L
E
Site 82
Y625
Q
K
R
E
A
E
R
Y
L
P
P
S
R
R
E
Site 83
S629
A
E
R
Y
L
P
P
S
R
R
E
G
P
T
F
Site 84
T635
P
S
R
R
E
G
P
T
F
R
R
D
R
E
R
Site 85
S644
R
R
D
R
E
R
E
S
W
S
G
E
T
R
Q
Site 86
S655
E
T
R
Q
D
G
E
S
K
T
I
M
L
K
R
Site 87
T657
R
Q
D
G
E
S
K
T
I
M
L
K
R
I
Y
Site 88
Y664
T
I
M
L
K
R
I
Y
R
S
T
P
P
E
V
Site 89
T667
L
K
R
I
Y
R
S
T
P
P
E
V
I
V
E
Site 90
T684
E
P
Y
V
R
L
T
T
A
N
V
R
I
I
K
Site 91
Y701
T
G
P
M
G
H
T
Y
G
F
I
D
L
D
S
Site 92
S727
Q
N
L
D
P
P
F
S
I
D
G
K
M
V
A
Site 93
S746
T
G
K
R
R
N
D
S
G
D
H
S
D
H
M
Site 94
Y755
D
H
S
D
H
M
H
Y
Y
Q
G
K
K
Y
F
Site 95
Y761
H
Y
Y
Q
G
K
K
Y
F
R
D
R
R
G
G
Site 96
S772
R
R
G
G
G
R
N
S
D
W
S
S
D
T
N
Site 97
S775
G
G
R
N
S
D
W
S
S
D
T
N
R
Q
G
Site 98
S776
G
R
N
S
D
W
S
S
D
T
N
R
Q
G
Q
Site 99
T778
N
S
D
W
S
S
D
T
N
R
Q
G
Q
Q
S
Site 100
S785
T
N
R
Q
G
Q
Q
S
S
S
D
C
Y
I
Y
Site 101
S786
N
R
Q
G
Q
Q
S
S
S
D
C
Y
I
Y
D
Site 102
S787
R
Q
G
Q
Q
S
S
S
D
C
Y
I
Y
D
S
Site 103
Y790
Q
Q
S
S
S
D
C
Y
I
Y
D
S
A
T
G
Site 104
Y792
S
S
S
D
C
Y
I
Y
D
S
A
T
G
Y
Y
Site 105
Y798
I
Y
D
S
A
T
G
Y
Y
Y
D
P
L
A
G
Site 106
Y799
Y
D
S
A
T
G
Y
Y
Y
D
P
L
A
G
T
Site 107
Y800
D
S
A
T
G
Y
Y
Y
D
P
L
A
G
T
Y
Site 108
Y807
Y
D
P
L
A
G
T
Y
Y
D
P
N
T
Q
Q
Site 109
Y808
D
P
L
A
G
T
Y
Y
D
P
N
T
Q
Q
E
Site 110
T812
G
T
Y
Y
D
P
N
T
Q
Q
E
V
Y
V
P
Site 111
Y817
P
N
T
Q
Q
E
V
Y
V
P
Q
D
P
G
L
Site 112
T836
E
I
K
E
K
K
P
T
S
Q
G
K
S
S
S
Site 113
S837
I
K
E
K
K
P
T
S
Q
G
K
S
S
S
K
Site 114
S841
K
P
T
S
Q
G
K
S
S
S
K
K
E
M
S
Site 115
S842
P
T
S
Q
G
K
S
S
S
K
K
E
M
S
K
Site 116
S843
T
S
Q
G
K
S
S
S
K
K
E
M
S
K
R
Site 117
S848
S
S
S
K
K
E
M
S
K
R
D
G
K
E
K
Site 118
T861
E
K
K
D
R
G
V
T
R
F
Q
E
N
A
S
Site 119
T885
F
K
K
P
L
P
P
T
V
K
K
E
E
S
P
Site 120
S891
P
T
V
K
K
E
E
S
P
P
P
P
K
V
V
Site 121
Y908
L
I
G
L
L
G
E
Y
G
G
D
S
D
Y
E
Site 122
S912
L
G
E
Y
G
G
D
S
D
Y
E
E
E
E
E
Site 123
Y914
E
Y
G
G
D
S
D
Y
E
E
E
E
E
E
E
Site 124
T923
E
E
E
E
E
E
Q
T
P
P
P
Q
P
R
T
Site 125
T930
T
P
P
P
Q
P
R
T
A
Q
P
Q
K
R
E
Site 126
T950
E
N
E
E
D
K
L
T
D
W
N
K
L
A
C
Site 127
S977
L
I
K
H
Q
Q
L
S
D
L
H
K
Q
N
L
Site 128
S993
I
H
R
K
I
K
Q
S
E
Q
E
L
A
Y
L
Site 129
Y999
Q
S
E
Q
E
L
A
Y
L
E
R
R
E
R
E
Site 130
S1022
D
R
R
E
K
L
Q
S
F
D
S
P
E
R
K
Site 131
S1025
E
K
L
Q
S
F
D
S
P
E
R
K
R
I
K
Site 132
Y1033
P
E
R
K
R
I
K
Y
S
R
E
T
D
S
D
Site 133
T1037
R
I
K
Y
S
R
E
T
D
S
D
R
K
L
V
Site 134
S1039
K
Y
S
R
E
T
D
S
D
R
K
L
V
D
K
Site 135
T1051
V
D
K
E
D
I
D
T
S
S
K
G
G
C
V
Site 136
S1053
K
E
D
I
D
T
S
S
K
G
G
C
V
Q
Q
Site 137
T1062
G
G
C
V
Q
Q
A
T
G
W
R
K
G
T
G
Site 138
T1068
A
T
G
W
R
K
G
T
G
L
G
Y
G
H
P
Site 139
Y1072
R
K
G
T
G
L
G
Y
G
H
P
G
L
A
S
Site 140
S1079
Y
G
H
P
G
L
A
S
S
E
E
A
E
G
R
Site 141
S1080
G
H
P
G
L
A
S
S
E
E
A
E
G
R
M
Site 142
S1091
E
G
R
M
R
G
P
S
V
G
A
S
G
R
T
Site 143
S1095
R
G
P
S
V
G
A
S
G
R
T
S
K
R
Q
Site 144
S1099
V
G
A
S
G
R
T
S
K
R
Q
S
N
E
T
Site 145
S1103
G
R
T
S
K
R
Q
S
N
E
T
Y
R
D
A
Site 146
T1106
S
K
R
Q
S
N
E
T
Y
R
D
A
V
R
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation