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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
EIF4G2
Full Name:
Eukaryotic translation initiation factor 4 gamma 2
Alias:
DAP5; Death associated protein 5; EIF4G 2; EIF-4G 2; EIF-4-gamma 2; Eukaryotic translation initiation factor 4 gamma, 2; IF4G2; NAT1; Novel APOBEC-1 target 1; P97; Translation repressor NAT1
Type:
Translation protein, initiation complex
Mass (Da):
102362
Number AA:
907
UniProt ID:
P78344
International Prot ID:
IPI00015952
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016281
GO:0032991
GO:0043234
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0003743
GO:0005488
PhosphoSite+
KinaseNET
Biological Process:
GO:0016070
GO:0007050
GO:0008219
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S3
_
_
_
_
_
M
E
S
A
I
A
E
G
G
A
Site 2
S11
A
I
A
E
G
G
A
S
R
F
S
A
S
S
G
Site 3
S14
E
G
G
A
S
R
F
S
A
S
S
G
G
G
G
Site 4
S16
G
A
S
R
F
S
A
S
S
G
G
G
G
S
R
Site 5
S17
A
S
R
F
S
A
S
S
G
G
G
G
S
R
G
Site 6
S22
A
S
S
G
G
G
G
S
R
G
A
P
Q
H
Y
Site 7
Y29
S
R
G
A
P
Q
H
Y
P
K
T
A
G
N
S
Site 8
T32
A
P
Q
H
Y
P
K
T
A
G
N
S
E
F
L
Site 9
T42
N
S
E
F
L
G
K
T
P
G
Q
N
A
Q
K
Site 10
S55
Q
K
W
I
P
A
R
S
T
R
R
D
D
N
S
Site 11
T56
K
W
I
P
A
R
S
T
R
R
D
D
N
S
A
Site 12
S62
S
T
R
R
D
D
N
S
A
A
N
N
S
A
N
Site 13
T89
R
G
I
L
N
K
L
T
P
E
K
F
D
K
L
Site 14
Y128
K
A
L
E
E
P
K
Y
S
S
L
Y
A
Q
L
Site 15
S130
L
E
E
P
K
Y
S
S
L
Y
A
Q
L
C
L
Site 16
Y132
E
P
K
Y
S
S
L
Y
A
Q
L
C
L
R
L
Site 17
S160
G
Q
P
G
Q
K
Q
S
T
T
F
R
R
L
L
Site 18
T162
P
G
Q
K
Q
S
T
T
F
R
R
L
L
I
S
Site 19
S169
T
F
R
R
L
L
I
S
K
L
Q
D
E
F
E
Site 20
Y185
R
T
R
N
V
D
V
Y
D
K
R
E
N
P
L
Site 21
S226
K
L
D
L
I
H
E
S
I
L
H
K
C
I
K
Site 22
S272
L
D
H
E
R
A
K
S
L
M
D
Q
Y
F
A
Site 23
Y277
A
K
S
L
M
D
Q
Y
F
A
R
M
C
S
L
Site 24
S283
Q
Y
F
A
R
M
C
S
L
M
L
S
K
E
L
Site 25
T301
I
R
F
L
L
Q
D
T
V
E
L
R
E
H
H
Site 26
T322
F
L
D
N
G
P
K
T
I
N
Q
I
R
Q
D
Site 27
S348
P
M
A
Q
G
M
R
S
D
F
F
L
E
G
P
Site 28
S381
M
F
G
Q
M
P
G
S
G
I
G
T
G
P
G
Site 29
T385
M
P
G
S
G
I
G
T
G
P
G
V
I
Q
D
Site 30
S395
G
V
I
Q
D
R
F
S
P
T
M
G
R
H
R
Site 31
T397
I
Q
D
R
F
S
P
T
M
G
R
H
R
S
N
Site 32
S403
P
T
M
G
R
H
R
S
N
Q
L
F
N
G
H
Site 33
T418
G
G
H
I
M
P
P
T
Q
S
Q
F
G
E
M
Site 34
S420
H
I
M
P
P
T
Q
S
Q
F
G
E
M
G
G
Site 35
S432
M
G
G
K
F
M
K
S
Q
G
L
S
Q
L
Y
Site 36
S436
F
M
K
S
Q
G
L
S
Q
L
Y
H
N
Q
S
Site 37
Y439
S
Q
G
L
S
Q
L
Y
H
N
Q
S
Q
G
L
Site 38
S443
S
Q
L
Y
H
N
Q
S
Q
G
L
L
S
Q
L
Site 39
S448
N
Q
S
Q
G
L
L
S
Q
L
Q
G
Q
S
K
Site 40
S454
L
S
Q
L
Q
G
Q
S
K
D
M
P
P
R
F
Site 41
S462
K
D
M
P
P
R
F
S
K
K
G
Q
L
N
A
Site 42
S473
Q
L
N
A
D
E
I
S
L
R
P
A
Q
S
F
Site 43
S479
I
S
L
R
P
A
Q
S
F
L
M
N
K
N
Q
Site 44
T495
P
K
L
Q
P
Q
I
T
M
I
P
P
S
A
Q
Site 45
S500
Q
I
T
M
I
P
P
S
A
Q
P
P
R
T
Q
Site 46
T506
P
S
A
Q
P
P
R
T
Q
T
P
P
L
G
Q
Site 47
T508
A
Q
P
P
R
T
Q
T
P
P
L
G
Q
T
P
Site 48
T514
Q
T
P
P
L
G
Q
T
P
Q
L
G
L
K
T
Site 49
T521
T
P
Q
L
G
L
K
T
N
P
P
L
I
Q
E
Site 50
S534
Q
E
K
P
A
K
T
S
K
K
P
P
P
S
K
Site 51
S540
T
S
K
K
P
P
P
S
K
E
E
L
L
K
L
Site 52
T553
K
L
T
E
T
V
V
T
E
Y
L
N
S
G
N
Site 53
Y555
T
E
T
V
V
T
E
Y
L
N
S
G
N
A
N
Site 54
S558
V
V
T
E
Y
L
N
S
G
N
A
N
E
A
V
Site 55
S589
L
S
K
V
I
I
L
S
L
D
R
S
D
E
D
Site 56
S593
I
I
L
S
L
D
R
S
D
E
D
K
E
K
A
Site 57
S601
D
E
D
K
E
K
A
S
S
L
I
S
L
L
K
Site 58
S602
E
D
K
E
K
A
S
S
L
I
S
L
L
K
Q
Site 59
S605
E
K
A
S
S
L
I
S
L
L
K
Q
E
G
I
Site 60
T614
L
K
Q
E
G
I
A
T
S
D
N
F
M
Q
A
Site 61
S615
K
Q
E
G
I
A
T
S
D
N
F
M
Q
A
F
Site 62
S641
V
D
I
P
L
V
K
S
Y
L
A
Q
F
A
A
Site 63
Y642
D
I
P
L
V
K
S
Y
L
A
Q
F
A
A
R
Site 64
S667
E
L
A
Q
P
L
E
S
G
T
H
F
P
L
F
Site 65
S746
K
Q
I
K
L
D
P
S
P
Q
T
I
Y
K
W
Site 66
Y751
D
P
S
P
Q
T
I
Y
K
W
I
K
D
N
I
Site 67
S759
K
W
I
K
D
N
I
S
P
K
L
H
V
D
K
Site 68
S781
T
S
F
L
Q
Y
I
S
S
E
V
N
P
P
S
Site 69
S782
S
F
L
Q
Y
I
S
S
E
V
N
P
P
S
D
Site 70
S788
S
S
E
V
N
P
P
S
D
E
T
D
S
S
S
Site 71
T791
V
N
P
P
S
D
E
T
D
S
S
S
A
P
S
Site 72
S793
P
P
S
D
E
T
D
S
S
S
A
P
S
K
E
Site 73
S794
P
S
D
E
T
D
S
S
S
A
P
S
K
E
Q
Site 74
S795
S
D
E
T
D
S
S
S
A
P
S
K
E
Q
L
Site 75
S798
T
D
S
S
S
A
P
S
K
E
Q
L
E
Q
E
Site 76
S811
Q
E
K
Q
L
L
L
S
F
K
P
V
M
Q
K
Site 77
Y839
Y
A
L
Q
V
H
C
Y
N
S
N
F
P
K
G
Site 78
T874
L
A
W
K
E
D
I
T
Q
E
F
P
G
K
G
Site 79
T896
Q
W
L
T
W
L
E
T
A
E
E
E
E
S
E
Site 80
S902
E
T
A
E
E
E
E
S
E
E
E
A
D
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation