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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ABCA4
Full Name:
Retinal-specific ATP-binding cassette transporter
Alias:
ABC10; ABCR; ARMD2; ATP binding cassette transporter; ATP-binding cassette sub-family A member 4
Type:
Transporter protein; Membrane fraction, membrane, integral plasma membrane protein
Mass (Da):
255944
Number AA:
2273
UniProt ID:
P78363
International Prot ID:
IPI00297763
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005887
GO:0005624
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0042626
PhosphoSite+
KinaseNET
Biological Process:
GO:0007603
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T16
L
L
L
W
K
N
W
T
L
R
K
R
Q
K
I
Site 2
Y49
L
R
N
A
N
P
L
Y
S
H
H
E
C
H
F
Site 3
S84
V
N
N
P
C
F
Q
S
P
T
P
G
E
S
P
Site 4
T86
N
P
C
F
Q
S
P
T
P
G
E
S
P
G
I
Site 5
S90
Q
S
P
T
P
G
E
S
P
G
I
V
S
N
Y
Site 6
S95
G
E
S
P
G
I
V
S
N
Y
N
N
S
I
L
Site 7
Y97
S
P
G
I
V
S
N
Y
N
N
S
I
L
A
R
Site 8
Y106
N
S
I
L
A
R
V
Y
R
D
F
Q
E
L
L
Site 9
S119
L
L
M
N
A
P
E
S
Q
H
L
G
R
I
W
Site 10
T127
Q
H
L
G
R
I
W
T
E
L
H
I
L
S
Q
Site 11
T138
I
L
S
Q
F
M
D
T
L
R
T
H
P
E
R
Site 12
S217
L
E
R
F
I
I
F
S
Q
R
R
G
A
K
T
Site 13
T224
S
Q
R
R
G
A
K
T
V
R
Y
A
L
C
S
Site 14
Y227
R
G
A
K
T
V
R
Y
A
L
C
S
L
S
Q
Site 15
Y245
Q
W
I
E
D
T
L
Y
A
N
V
D
F
F
K
Site 16
T259
K
L
F
R
V
L
P
T
L
L
D
S
R
S
Q
Site 17
S265
P
T
L
L
D
S
R
S
Q
G
I
N
L
R
S
Site 18
S272
S
Q
G
I
N
L
R
S
W
G
G
I
L
S
D
Site 19
S278
R
S
W
G
G
I
L
S
D
M
S
P
R
I
Q
Site 20
T311
M
Q
N
G
G
P
E
T
F
T
K
L
M
G
I
Site 21
Y326
L
S
D
L
L
C
G
Y
P
E
G
G
G
S
R
Site 22
S332
G
Y
P
E
G
G
G
S
R
V
L
S
F
N
W
Site 23
S336
G
G
G
S
R
V
L
S
F
N
W
Y
E
D
N
Site 24
Y340
R
V
L
S
F
N
W
Y
E
D
N
N
Y
K
A
Site 25
Y345
N
W
Y
E
D
N
N
Y
K
A
F
L
G
I
D
Site 26
S353
K
A
F
L
G
I
D
S
T
R
K
D
P
I
Y
Site 27
T354
A
F
L
G
I
D
S
T
R
K
D
P
I
Y
S
Site 28
Y360
S
T
R
K
D
P
I
Y
S
Y
D
R
R
T
T
Site 29
S361
T
R
K
D
P
I
Y
S
Y
D
R
R
T
T
S
Site 30
Y362
R
K
D
P
I
Y
S
Y
D
R
R
T
T
S
F
Site 31
T366
I
Y
S
Y
D
R
R
T
T
S
F
C
N
A
L
Site 32
T367
Y
S
Y
D
R
R
T
T
S
F
C
N
A
L
I
Site 33
S368
S
Y
D
R
R
T
T
S
F
C
N
A
L
I
Q
Site 34
T383
S
L
E
S
N
P
L
T
K
I
A
W
R
A
A
Site 35
Y400
L
L
M
G
K
I
L
Y
T
P
D
S
P
A
A
Site 36
T401
L
M
G
K
I
L
Y
T
P
D
S
P
A
A
R
Site 37
S404
K
I
L
Y
T
P
D
S
P
A
A
R
R
I
L
Site 38
S416
R
I
L
K
N
A
N
S
T
F
E
E
L
E
H
Site 39
T417
I
L
K
N
A
N
S
T
F
E
E
L
E
H
V
Site 40
Y440
E
V
G
P
Q
I
W
Y
F
F
D
N
S
T
Q
Site 41
T454
Q
M
N
M
I
R
D
T
L
G
N
P
T
V
K
Site 42
T459
R
D
T
L
G
N
P
T
V
K
D
F
L
N
R
Site 43
Y483
E
A
I
L
N
F
L
Y
K
G
P
R
E
S
Q
Site 44
S489
L
Y
K
G
P
R
E
S
Q
A
D
D
M
A
N
Site 45
T506
W
R
D
I
F
N
I
T
D
R
T
L
R
L
V
Site 46
T509
I
F
N
I
T
D
R
T
L
R
L
V
N
Q
Y
Site 47
S527
L
V
L
D
K
F
E
S
Y
N
D
E
T
Q
L
Site 48
T535
Y
N
D
E
T
Q
L
T
Q
R
A
L
S
L
L
Site 49
S540
Q
L
T
Q
R
A
L
S
L
L
E
E
N
M
F
Site 50
T560
F
P
D
M
Y
P
W
T
S
S
L
P
P
H
V
Site 51
Y569
S
L
P
P
H
V
K
Y
K
I
R
M
D
I
D
Site 52
Y588
T
N
K
I
K
D
R
Y
W
D
S
G
P
R
A
Site 53
S591
I
K
D
R
Y
W
D
S
G
P
R
A
D
P
V
Site 54
Y603
D
P
V
E
D
F
R
Y
I
W
G
G
F
A
Y
Site 55
T620
D
M
V
E
Q
G
I
T
R
S
Q
V
Q
A
E
Site 56
S622
V
E
Q
G
I
T
R
S
Q
V
Q
A
E
A
P
Site 57
Y633
A
E
A
P
V
G
I
Y
L
Q
Q
M
P
Y
P
Site 58
Y639
I
Y
L
Q
Q
M
P
Y
P
C
F
V
D
D
S
Site 59
T685
K
E
L
R
L
K
E
T
L
K
N
Q
G
V
S
Site 60
T787
F
A
W
Q
D
R
M
T
A
E
L
K
K
A
V
Site 61
Y808
A
F
G
F
G
T
E
Y
L
V
R
F
E
E
Q
Site 62
S822
Q
G
L
G
L
Q
W
S
N
I
G
N
S
P
T
Site 63
S827
Q
W
S
N
I
G
N
S
P
T
E
G
D
E
F
Site 64
T829
S
N
I
G
N
S
P
T
E
G
D
E
F
S
F
Site 65
S835
P
T
E
G
D
E
F
S
F
L
L
S
M
Q
M
Site 66
Y865
D
Q
V
F
P
G
D
Y
G
T
P
L
P
W
Y
Site 67
Y872
Y
G
T
P
L
P
W
Y
F
L
L
Q
E
S
Y
Site 68
Y879
Y
F
L
L
Q
E
S
Y
W
L
G
G
E
G
C
Site 69
S887
W
L
G
G
E
G
C
S
T
R
E
E
R
A
L
Site 70
T888
L
G
G
E
G
C
S
T
R
E
E
R
A
L
E
Site 71
T897
E
E
R
A
L
E
K
T
E
P
L
T
E
E
T
Site 72
T901
L
E
K
T
E
P
L
T
E
E
T
E
D
P
E
Site 73
S916
H
P
E
G
I
H
D
S
F
F
E
R
E
H
P
Site 74
T952
A
V
D
R
L
N
I
T
F
Y
E
N
Q
I
T
Site 75
Y954
D
R
L
N
I
T
F
Y
E
N
Q
I
T
A
F
Site 76
T970
G
H
N
G
A
G
K
T
T
T
L
S
I
L
T
Site 77
T996
V
G
G
R
D
I
E
T
S
L
D
A
V
R
Q
Site 78
S997
G
G
R
D
I
E
T
S
L
D
A
V
R
Q
S
Site 79
S1004
S
L
D
A
V
R
Q
S
L
G
M
C
P
Q
H
Site 80
S1071
G
G
M
Q
R
K
L
S
V
A
I
A
F
V
G
Site 81
S1090
V
I
L
D
E
P
T
S
G
V
D
P
Y
S
R
Site 82
Y1095
P
T
S
G
V
D
P
Y
S
R
R
S
I
W
D
Site 83
S1096
T
S
G
V
D
P
Y
S
R
R
S
I
W
D
L
Site 84
S1099
V
D
P
Y
S
R
R
S
I
W
D
L
L
L
K
Site 85
S1109
D
L
L
L
K
Y
R
S
G
R
T
I
I
M
S
Site 86
S1168
R
K
M
K
N
I
Q
S
Q
R
K
G
S
E
G
Site 87
S1173
I
Q
S
Q
R
K
G
S
E
G
T
C
S
C
S
Site 88
T1176
Q
R
K
G
S
E
G
T
C
S
C
S
S
K
G
Site 89
S1178
K
G
S
E
G
T
C
S
C
S
S
K
G
F
S
Site 90
S1180
S
E
G
T
C
S
C
S
S
K
G
F
S
T
T
Site 91
S1181
E
G
T
C
S
C
S
S
K
G
F
S
T
T
C
Site 92
S1185
S
C
S
S
K
G
F
S
T
T
C
P
A
H
V
Site 93
T1186
C
S
S
K
G
F
S
T
T
C
P
A
H
V
D
Site 94
T1196
P
A
H
V
D
D
L
T
P
E
Q
V
L
D
G
Site 95
Y1243
K
N
F
K
H
R
A
Y
A
S
L
F
R
E
L
Site 96
S1245
F
K
H
R
A
Y
A
S
L
F
R
E
L
E
E
Site 97
T1267
S
S
F
G
I
S
D
T
P
L
E
E
I
F
L
Site 98
S1280
F
L
K
V
T
E
D
S
D
S
G
P
L
F
A
Site 99
S1282
K
V
T
E
D
S
D
S
G
P
L
F
A
G
G
Site 100
T1313
P
R
E
K
A
G
Q
T
P
Q
D
S
N
V
C
Site 101
S1317
A
G
Q
T
P
Q
D
S
N
V
C
S
P
G
A
Site 102
S1321
P
Q
D
S
N
V
C
S
P
G
A
P
A
A
H
Site 103
T1366
L
V
K
R
F
Q
H
T
I
R
S
H
K
D
F
Site 104
S1418
G
Q
Q
Y
T
F
F
S
M
D
E
P
G
S
E
Site 105
S1424
F
S
M
D
E
P
G
S
E
Q
F
T
V
L
A
Site 106
Y1453
K
E
G
W
L
P
E
Y
P
C
G
N
S
T
P
Site 107
S1458
P
E
Y
P
C
G
N
S
T
P
W
K
T
P
S
Site 108
T1459
E
Y
P
C
G
N
S
T
P
W
K
T
P
S
V
Site 109
T1463
G
N
S
T
P
W
K
T
P
S
V
S
P
N
I
Site 110
S1465
S
T
P
W
K
T
P
S
V
S
P
N
I
T
Q
Site 111
S1467
P
W
K
T
P
S
V
S
P
N
I
T
Q
L
F
Site 112
T1471
P
S
V
S
P
N
I
T
Q
L
F
Q
K
Q
K
Site 113
S1485
K
W
T
Q
V
N
P
S
P
S
C
R
C
S
T
Site 114
S1487
T
Q
V
N
P
S
P
S
C
R
C
S
T
R
E
Site 115
S1491
P
S
P
S
C
R
C
S
T
R
E
K
L
T
M
Site 116
T1492
S
P
S
C
R
C
S
T
R
E
K
L
T
M
L
Site 117
T1515
G
L
P
P
P
Q
R
T
Q
R
S
T
E
I
L
Site 118
S1518
P
P
Q
R
T
Q
R
S
T
E
I
L
Q
D
L
Site 119
T1519
P
Q
R
T
Q
R
S
T
E
I
L
Q
D
L
T
Site 120
T1526
T
E
I
L
Q
D
L
T
D
R
N
I
S
D
F
Site 121
S1531
D
L
T
D
R
N
I
S
D
F
L
V
K
T
Y
Site 122
S1544
T
Y
P
A
L
I
R
S
S
L
K
S
K
F
W
Site 123
S1545
Y
P
A
L
I
R
S
S
L
K
S
K
F
W
V
Site 124
S1548
L
I
R
S
S
L
K
S
K
F
W
V
N
E
Q
Site 125
Y1557
F
W
V
N
E
Q
R
Y
G
G
I
S
I
G
G
Site 126
S1561
E
Q
R
Y
G
G
I
S
I
G
G
K
L
P
V
Site 127
S1590
L
G
R
I
M
N
V
S
G
G
P
I
T
R
E
Site 128
T1595
N
V
S
G
G
P
I
T
R
E
A
S
K
E
I
Site 129
S1599
G
P
I
T
R
E
A
S
K
E
I
P
D
F
L
Site 130
S1642
H
N
A
I
L
R
A
S
L
P
K
D
R
S
P
Site 131
S1648
A
S
L
P
K
D
R
S
P
E
E
Y
G
I
T
Site 132
Y1652
K
D
R
S
P
E
E
Y
G
I
T
V
I
S
Q
Site 133
T1655
S
P
E
E
Y
G
I
T
V
I
S
Q
P
L
N
Site 134
S1658
E
Y
G
I
T
V
I
S
Q
P
L
N
L
T
K
Site 135
S1709
I
Q
E
R
V
N
K
S
K
H
L
Q
F
I
S
Site 136
S1716
S
K
H
L
Q
F
I
S
G
V
S
P
T
T
Y
Site 137
Y1754
I
G
F
Q
K
K
A
Y
T
S
P
E
N
L
P
Site 138
S1756
F
Q
K
K
A
Y
T
S
P
E
N
L
P
A
L
Site 139
T1821
E
L
F
E
N
N
R
T
L
L
R
F
N
A
V
Site 140
Y1858
S
Q
A
V
T
D
V
Y
A
R
F
G
E
E
H
Site 141
T1930
E
E
R
Q
R
I
I
T
G
G
N
K
T
D
I
Site 142
T1935
I
I
T
G
G
N
K
T
D
I
L
R
L
H
E
Site 143
T1944
I
L
R
L
H
E
L
T
K
I
Y
P
G
T
S
Site 144
Y1947
L
H
E
L
T
K
I
Y
P
G
T
S
S
P
A
Site 145
T1950
L
T
K
I
Y
P
G
T
S
S
P
A
V
D
R
Site 146
S1952
K
I
Y
P
G
T
S
S
P
A
V
D
R
L
C
Site 147
T1981
N
G
A
G
K
T
T
T
F
K
M
L
T
G
D
Site 148
T1990
K
M
L
T
G
D
T
T
V
T
S
G
D
A
T
Site 149
S1993
T
G
D
T
T
V
T
S
G
D
A
T
V
A
G
Site 150
T2028
D
A
I
D
E
L
L
T
G
R
E
H
L
Y
L
Site 151
Y2034
L
T
G
R
E
H
L
Y
L
Y
A
R
L
R
G
Site 152
Y2036
G
R
E
H
L
Y
L
Y
A
R
L
R
G
V
P
Site 153
S2072
D
C
L
A
G
T
Y
S
G
G
N
K
R
K
L
Site 154
S2080
G
G
N
K
R
K
L
S
T
A
I
A
L
I
G
Site 155
T2098
L
V
L
L
D
E
P
T
T
G
M
D
P
Q
A
Site 156
S2115
M
L
W
N
V
I
V
S
I
I
R
E
G
R
A
Site 157
T2126
E
G
R
A
V
V
L
T
S
H
S
M
E
E
C
Site 158
S2159
G
T
I
Q
H
L
K
S
K
F
G
D
G
Y
I
Site 159
Y2165
K
S
K
F
G
D
G
Y
I
V
T
M
K
I
K
Site 160
T2168
F
G
D
G
Y
I
V
T
M
K
I
K
S
P
K
Site 161
S2173
I
V
T
M
K
I
K
S
P
K
D
D
L
L
P
Site 162
S2196
F
Q
G
N
F
P
G
S
V
Q
R
E
R
H
Y
Site 163
Y2203
S
V
Q
R
E
R
H
Y
N
M
L
Q
F
Q
V
Site 164
S2228
L
L
L
S
H
K
D
S
L
L
I
E
E
Y
S
Site 165
S2235
S
L
L
I
E
E
Y
S
V
T
Q
T
T
L
D
Site 166
T2237
L
I
E
E
Y
S
V
T
Q
T
T
L
D
Q
V
Site 167
S2268
H
P
R
A
A
G
A
S
R
Q
A
Q
D
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation