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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
KRT85
Full Name:
Keratin, type II cuticular Hb5
Alias:
Hair keratin K2.12;Keratin-85;Type II hair keratin Hb5;Type-II keratin Kb25
Type:
Mass (Da):
55802
Number AA:
507
UniProt ID:
P78386
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S2
_
_
_
_
_
_
M
S
C
R
S
Y
R
I
S
Site 2
S9
S
C
R
S
Y
R
I
S
S
G
C
G
V
T
R
Site 3
S10
C
R
S
Y
R
I
S
S
G
C
G
V
T
R
N
Site 4
T15
I
S
S
G
C
G
V
T
R
N
F
S
S
C
S
Site 5
S20
G
V
T
R
N
F
S
S
C
S
A
V
A
P
K
Site 6
S43
A
A
P
Y
R
G
V
S
C
Y
R
G
L
T
G
Site 7
Y45
P
Y
R
G
V
S
C
Y
R
G
L
T
G
F
G
Site 8
T49
V
S
C
Y
R
G
L
T
G
F
G
S
R
S
L
Site 9
S53
R
G
L
T
G
F
G
S
R
S
L
C
N
L
G
Site 10
S75
V
G
G
F
R
A
G
S
C
G
R
S
F
G
Y
Site 11
S79
R
A
G
S
C
G
R
S
F
G
Y
R
S
G
G
Site 12
Y82
S
C
G
R
S
F
G
Y
R
S
G
G
V
C
G
Site 13
S84
G
R
S
F
G
Y
R
S
G
G
V
C
G
P
S
Site 14
S129
E
E
K
E
Q
I
K
S
L
N
S
R
F
A
A
Site 15
S173
S
N
L
E
P
L
F
S
G
Y
I
E
T
L
R
Site 16
T178
L
F
S
G
Y
I
E
T
L
R
R
E
A
E
C
Site 17
S190
A
E
C
V
E
A
D
S
G
R
L
A
S
E
L
Site 18
S195
A
D
S
G
R
L
A
S
E
L
N
H
V
Q
E
Site 19
Y211
L
E
G
Y
K
K
K
Y
E
E
E
V
A
L
R
Site 20
Y236
K
K
D
V
D
C
A
Y
L
R
K
S
D
L
E
Site 21
S240
D
C
A
Y
L
R
K
S
D
L
E
A
N
V
E
Site 22
S254
E
A
L
V
E
E
S
S
F
L
R
R
L
Y
E
Site 23
Y260
S
S
F
L
R
R
L
Y
E
E
E
I
R
V
L
Site 24
S275
Q
A
H
I
S
D
T
S
V
I
V
K
M
D
N
Site 25
S306
Y
D
D
V
A
S
R
S
R
A
E
A
E
S
W
Site 26
S312
R
S
R
A
E
A
E
S
W
Y
R
S
K
C
E
Site 27
Y314
R
A
E
A
E
S
W
Y
R
S
K
C
E
E
M
Site 28
S316
E
A
E
S
W
Y
R
S
K
C
E
E
M
K
A
Site 29
T324
K
C
E
E
M
K
A
T
V
I
R
H
G
E
T
Site 30
T331
T
V
I
R
H
G
E
T
L
R
R
T
K
E
E
Site 31
T335
H
G
E
T
L
R
R
T
K
E
E
I
N
E
L
Site 32
T350
N
R
M
I
Q
R
L
T
A
E
I
E
N
A
K
Site 33
S379
Q
Q
G
E
A
A
L
S
D
A
R
C
K
L
A
Site 34
Y406
M
A
C
L
L
K
E
Y
Q
E
V
M
N
S
K
Site 35
T422
G
L
D
I
E
I
A
T
Y
R
R
L
L
E
G
Site 36
Y423
L
D
I
E
I
A
T
Y
R
R
L
L
E
G
E
Site 37
S453
S
S
S
R
G
G
V
S
C
G
G
L
S
Y
S
Site 38
S458
G
V
S
C
G
G
L
S
Y
S
T
T
P
G
R
Site 39
S460
S
C
G
G
L
S
Y
S
T
T
P
G
R
Q
I
Site 40
T462
G
G
L
S
Y
S
T
T
P
G
R
Q
I
T
S
Site 41
T468
T
T
P
G
R
Q
I
T
S
G
P
S
A
I
G
Site 42
S469
T
P
G
R
Q
I
T
S
G
P
S
A
I
G
G
Site 43
S472
R
Q
I
T
S
G
P
S
A
I
G
G
S
I
T
Site 44
S493
C
A
P
C
Q
P
R
S
S
S
F
S
C
G
S
Site 45
S494
A
P
C
Q
P
R
S
S
S
F
S
C
G
S
S
Site 46
S495
P
C
Q
P
R
S
S
S
F
S
C
G
S
S
R
Site 47
S497
Q
P
R
S
S
S
F
S
C
G
S
S
R
S
V
Site 48
S500
S
S
S
F
S
C
G
S
S
R
S
V
R
F
A
Site 49
S501
S
S
F
S
C
G
S
S
R
S
V
R
F
A
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation