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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PRAME
Full Name:
Melanoma antigen preferentially expressed in tumors
Alias:
Opa-interacting protein 4;Preferentially expressed antigen of melanoma
Type:
Mass (Da):
57890
Number AA:
509
UniProt ID:
P78395
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S9
E
R
R
R
L
W
G
S
I
Q
S
R
Y
I
S
Site 2
S12
R
L
W
G
S
I
Q
S
R
Y
I
S
M
S
V
Site 3
Y14
W
G
S
I
Q
S
R
Y
I
S
M
S
V
W
T
Site 4
S16
S
I
Q
S
R
Y
I
S
M
S
V
W
T
S
P
Site 5
S18
Q
S
R
Y
I
S
M
S
V
W
T
S
P
R
R
Site 6
S66
A
A
F
D
G
R
H
S
Q
T
L
K
A
M
V
Site 7
T96
G
Q
H
L
H
L
E
T
F
K
A
V
L
D
G
Site 8
S142
V
W
S
G
N
R
A
S
L
Y
S
F
P
E
P
Site 9
Y144
S
G
N
R
A
S
L
Y
S
F
P
E
P
E
A
Site 10
S145
G
N
R
A
S
L
Y
S
F
P
E
P
E
A
A
Site 11
S165
K
R
K
V
D
G
L
S
T
E
A
E
Q
P
F
Site 12
Y194
A
C
D
E
L
F
S
Y
L
I
E
K
V
K
R
Site 13
T248
T
C
T
W
K
L
P
T
L
A
K
F
S
P
Y
Site 14
S268
N
L
R
R
L
L
L
S
H
I
H
A
S
S
Y
Site 15
S273
L
L
S
H
I
H
A
S
S
Y
I
S
P
E
K
Site 16
S274
L
S
H
I
H
A
S
S
Y
I
S
P
E
K
E
Site 17
Y275
S
H
I
H
A
S
S
Y
I
S
P
E
K
E
E
Site 18
S277
I
H
A
S
S
Y
I
S
P
E
K
E
E
Q
Y
Site 19
Y284
S
P
E
K
E
E
Q
Y
I
A
Q
F
T
S
Q
Site 20
S328
M
N
P
L
E
T
L
S
I
T
N
C
R
L
S
Site 21
T330
P
L
E
T
L
S
I
T
N
C
R
L
S
E
G
Site 22
S335
S
I
T
N
C
R
L
S
E
G
D
V
M
H
L
Site 23
S343
E
G
D
V
M
H
L
S
Q
S
P
S
V
S
Q
Site 24
S345
D
V
M
H
L
S
Q
S
P
S
V
S
Q
L
S
Site 25
T409
L
S
H
C
S
Q
L
T
T
L
S
F
Y
G
N
Site 26
T410
S
H
C
S
Q
L
T
T
L
S
F
Y
G
N
S
Site 27
Y441
S
N
L
T
H
V
L
Y
P
V
P
L
E
S
Y
Site 28
S447
L
Y
P
V
P
L
E
S
Y
E
D
I
H
G
T
Site 29
Y448
Y
P
V
P
L
E
S
Y
E
D
I
H
G
T
L
Site 30
Y462
L
H
L
E
R
L
A
Y
L
H
A
R
L
R
E
Site 31
T494
C
P
H
C
G
D
R
T
F
Y
D
P
E
P
I
Site 32
Y496
H
C
G
D
R
T
F
Y
D
P
E
P
I
L
C
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation