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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
IRX1
Full Name:
Iroquois-class homeodomain protein IRX-1
Alias:
Iroquois homeobox 1; IRX-5; IRXA1
Type:
Nucleus protein
Mass (Da):
49621
Number AA:
480
UniProt ID:
P78414
International Prot ID:
IPI00375629
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0043565
GO:0003700
PhosphoSite+
KinaseNET
Biological Process:
GO:0006355
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y8
M
S
F
P
Q
L
G
Y
P
Q
Y
L
S
A
A
Site 2
Y11
P
Q
L
G
Y
P
Q
Y
L
S
A
A
G
P
G
Site 3
S13
L
G
Y
P
Q
Y
L
S
A
A
G
P
G
A
Y
Site 4
S40
A
A
A
A
A
A
S
S
G
R
P
G
A
A
E
Site 5
Y76
P
Y
A
G
A
P
N
Y
S
A
F
L
P
Y
A
Site 6
S90
A
A
D
L
S
L
F
S
Q
M
G
S
Q
Y
E
Site 7
S94
S
L
F
S
Q
M
G
S
Q
Y
E
L
K
D
N
Site 8
T108
N
P
G
V
H
P
A
T
F
A
A
H
T
A
P
Site 9
Y117
A
A
H
T
A
P
A
Y
Y
P
Y
G
Q
F
Q
Site 10
Y118
A
H
T
A
P
A
Y
Y
P
Y
G
Q
F
Q
Y
Site 11
Y125
Y
P
Y
G
Q
F
Q
Y
G
D
P
G
R
P
K
Site 12
T135
P
G
R
P
K
N
A
T
R
E
S
T
S
T
L
Site 13
S138
P
K
N
A
T
R
E
S
T
S
T
L
K
A
W
Site 14
T139
K
N
A
T
R
E
S
T
S
T
L
K
A
W
L
Site 15
T141
A
T
R
E
S
T
S
T
L
K
A
W
L
N
E
Site 16
Y154
N
E
H
R
K
N
P
Y
P
T
K
G
E
K
I
Site 17
T192
L
K
K
E
N
K
V
T
W
G
A
R
S
K
D
Site 18
S208
E
D
G
A
L
F
G
S
D
T
E
G
D
P
E
Site 19
T210
G
A
L
F
G
S
D
T
E
G
D
P
E
K
A
Site 20
S241
D
E
H
D
G
D
Q
S
N
E
D
D
E
D
K
Site 21
S280
D
V
L
K
P
Q
D
S
P
L
G
L
A
K
E
Site 22
S293
K
E
A
P
E
P
G
S
T
R
L
L
S
P
G
Site 23
T294
E
A
P
E
P
G
S
T
R
L
L
S
P
G
A
Site 24
S298
P
G
S
T
R
L
L
S
P
G
A
A
A
G
G
Site 25
S318
H
G
K
P
K
I
W
S
L
A
E
T
A
T
S
Site 26
T322
K
I
W
S
L
A
E
T
A
T
S
P
D
G
A
Site 27
S325
S
L
A
E
T
A
T
S
P
D
G
A
P
K
A
Site 28
S333
P
D
G
A
P
K
A
S
P
P
P
P
A
G
H
Site 29
T375
I
G
K
F
S
N
W
T
N
S
A
F
L
A
Q
Site 30
S429
A
L
N
G
D
K
A
S
V
R
S
S
P
T
L
Site 31
S433
D
K
A
S
V
R
S
S
P
T
L
P
E
R
D
Site 32
S447
D
L
V
P
R
P
D
S
P
A
Q
Q
L
K
S
Site 33
S454
S
P
A
Q
Q
L
K
S
P
F
Q
P
V
R
D
Site 34
S463
F
Q
P
V
R
D
N
S
L
A
P
Q
E
G
T
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation