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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
NKX6-1
Full Name:
Homeobox protein Nkx-6.1
Alias:
Homeobox protein NK-6 homolog A
Type:
Mass (Da):
37849
Number AA:
367
UniProt ID:
P78426
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S13
A
M
E
G
T
R
Q
S
A
F
L
L
S
S
P
Site 2
S27
P
P
L
A
A
L
H
S
M
A
E
M
K
T
P
Site 3
T33
H
S
M
A
E
M
K
T
P
L
Y
P
A
A
Y
Site 4
Y36
A
E
M
K
T
P
L
Y
P
A
A
Y
P
P
L
Site 5
Y40
T
P
L
Y
P
A
A
Y
P
P
L
P
A
G
P
Site 6
S49
P
L
P
A
G
P
P
S
S
S
S
S
S
S
S
Site 7
S50
L
P
A
G
P
P
S
S
S
S
S
S
S
S
S
Site 8
S51
P
A
G
P
P
S
S
S
S
S
S
S
S
S
S
Site 9
S52
A
G
P
P
S
S
S
S
S
S
S
S
S
S
S
Site 10
S53
G
P
P
S
S
S
S
S
S
S
S
S
S
S
P
Site 11
S54
P
P
S
S
S
S
S
S
S
S
S
S
S
P
S
Site 12
S55
P
S
S
S
S
S
S
S
S
S
S
S
P
S
P
Site 13
S56
S
S
S
S
S
S
S
S
S
S
S
P
S
P
P
Site 14
S57
S
S
S
S
S
S
S
S
S
S
P
S
P
P
L
Site 15
S58
S
S
S
S
S
S
S
S
S
P
S
P
P
L
G
Site 16
S59
S
S
S
S
S
S
S
S
P
S
P
P
L
G
T
Site 17
S61
S
S
S
S
S
S
P
S
P
P
L
G
T
H
N
Site 18
T66
S
P
S
P
P
L
G
T
H
N
P
G
G
L
K
Site 19
T77
G
G
L
K
P
P
A
T
G
G
L
S
S
L
G
Site 20
S81
P
P
A
T
G
G
L
S
S
L
G
S
P
P
Q
Site 21
S82
P
A
T
G
G
L
S
S
L
G
S
P
P
Q
Q
Site 22
S85
G
G
L
S
S
L
G
S
P
P
Q
Q
L
S
A
Site 23
S91
G
S
P
P
Q
Q
L
S
A
A
T
P
H
G
I
Site 24
T94
P
Q
Q
L
S
A
A
T
P
H
G
I
N
N
I
Site 25
S103
H
G
I
N
N
I
L
S
R
P
S
M
P
V
A
Site 26
S106
N
N
I
L
S
R
P
S
M
P
V
A
S
G
A
Site 27
S117
A
S
G
A
A
L
P
S
A
S
P
S
G
S
S
Site 28
S119
G
A
A
L
P
S
A
S
P
S
G
S
S
S
S
Site 29
S121
A
L
P
S
A
S
P
S
G
S
S
S
S
S
S
Site 30
S123
P
S
A
S
P
S
G
S
S
S
S
S
S
S
S
Site 31
S124
S
A
S
P
S
G
S
S
S
S
S
S
S
S
A
Site 32
S125
A
S
P
S
G
S
S
S
S
S
S
S
S
A
S
Site 33
S126
S
P
S
G
S
S
S
S
S
S
S
S
A
S
A
Site 34
S127
P
S
G
S
S
S
S
S
S
S
S
A
S
A
S
Site 35
S128
S
G
S
S
S
S
S
S
S
S
A
S
A
S
S
Site 36
S129
G
S
S
S
S
S
S
S
S
A
S
A
S
S
A
Site 37
S130
S
S
S
S
S
S
S
S
A
S
A
S
S
A
S
Site 38
S132
S
S
S
S
S
S
A
S
A
S
S
A
S
A
A
Site 39
S134
S
S
S
S
A
S
A
S
S
A
S
A
A
A
A
Site 40
S164
L
A
G
L
P
R
F
S
S
L
S
P
P
P
P
Site 41
S165
A
G
L
P
R
F
S
S
L
S
P
P
P
P
P
Site 42
S167
L
P
R
F
S
S
L
S
P
P
P
P
P
P
G
Site 43
Y176
P
P
P
P
P
G
L
Y
F
S
P
S
A
A
A
Site 44
T222
R
D
A
R
L
A
C
T
P
H
Q
G
S
I
L
Site 45
T239
K
D
G
K
R
K
H
T
R
P
T
F
S
G
Q
Site 46
T242
K
R
K
H
T
R
P
T
F
S
G
Q
Q
I
F
Site 47
T254
Q
I
F
A
L
E
K
T
F
E
Q
T
K
Y
L
Site 48
Y260
K
T
F
E
Q
T
K
Y
L
A
G
P
E
R
A
Site 49
Y271
P
E
R
A
R
L
A
Y
S
L
G
M
T
E
S
Site 50
S272
E
R
A
R
L
A
Y
S
L
G
M
T
E
S
Q
Site 51
S308
T
A
K
K
K
Q
D
S
E
T
E
R
L
K
G
Site 52
T310
K
K
K
Q
D
S
E
T
E
R
L
K
G
A
S
Site 53
S317
T
E
R
L
K
G
A
S
E
N
E
E
E
D
D
Site 54
Y326
N
E
E
E
D
D
D
Y
N
K
P
L
D
P
N
Site 55
S334
N
K
P
L
D
P
N
S
D
D
E
K
I
T
Q
Site 56
S348
Q
L
L
K
K
H
K
S
S
S
G
G
G
G
G
Site 57
S349
L
L
K
K
H
K
S
S
S
G
G
G
G
G
L
Site 58
S350
L
K
K
H
K
S
S
S
G
G
G
G
G
L
L
Site 59
S361
G
G
L
L
L
H
A
S
E
P
E
S
S
S
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation