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Updated November 2019
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Protein Info
Short Name:
RELN
Full Name:
Reelin
Alias:
EC 3.4.21.-; PRO1598; Reelin; RL
Type:
EC 3.4.21.-; Protease; Cell development/differentiation; Adhesion; Motility/polarity/chemotaxis
Mass (Da):
388402
Number AA:
3460
UniProt ID:
P78509
International Prot ID:
IPI00241562
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005578
Uniprot
OncoNet
Molecular Function:
GO:0005509
GO:0005515
GO:0008236
PhosphoSite+
KinaseNET
Biological Process:
GO:0007155
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T10
R
S
G
W
A
R
Q
T
F
L
L
A
L
L
L
Site 2
Y29
R
A
R
A
A
A
G
Y
Y
P
R
F
S
P
F
Site 3
Y30
A
R
A
A
A
G
Y
Y
P
R
F
S
P
F
F
Site 4
T41
S
P
F
F
F
L
C
T
H
H
G
E
L
E
G
Site 5
Y67
H
I
A
G
N
P
T
Y
Y
V
P
G
Q
E
Y
Site 6
Y68
I
A
G
N
P
T
Y
Y
V
P
G
Q
E
Y
H
Site 7
T77
P
G
Q
E
Y
H
V
T
I
S
T
S
T
F
F
Site 8
S97
T
G
L
Y
T
S
T
S
V
Q
A
S
Q
S
I
Site 9
S101
T
S
T
S
V
Q
A
S
Q
S
I
G
G
S
S
Site 10
S103
T
S
V
Q
A
S
Q
S
I
G
G
S
S
A
F
Site 11
T138
S
H
V
S
H
L
P
T
T
N
L
S
F
I
W
Site 12
T187
Q
G
A
P
T
D
V
T
V
H
P
H
L
A
E
Site 13
S197
P
H
L
A
E
I
H
S
D
S
I
I
L
R
D
Site 14
S208
I
L
R
D
D
F
D
S
Y
H
Q
L
Q
L
N
Site 15
Y209
L
R
D
D
F
D
S
Y
H
Q
L
Q
L
N
P
Site 16
T254
G
P
R
E
L
I
T
T
G
L
N
T
T
T
A
Site 17
S272
Q
F
S
I
G
S
G
S
C
R
F
S
Y
S
D
Site 18
S276
G
S
G
S
C
R
F
S
Y
S
D
P
S
I
I
Site 19
Y277
S
G
S
C
R
F
S
Y
S
D
P
S
I
I
V
Site 20
Y286
D
P
S
I
I
V
L
Y
A
K
N
N
S
A
D
Site 21
S304
L
E
K
I
R
A
P
S
N
V
S
T
I
I
H
Site 22
S363
R
Q
V
V
L
E
D
S
L
D
P
V
D
T
G
Site 23
T369
D
S
L
D
P
V
D
T
G
N
W
L
F
F
P
Site 24
S383
P
G
A
T
V
K
H
S
C
Q
S
D
G
N
S
Site 25
Y392
Q
S
D
G
N
S
I
Y
F
H
G
N
E
G
S
Site 26
T405
G
S
E
F
N
F
A
T
T
R
D
V
D
L
S
Site 27
S412
T
T
R
D
V
D
L
S
T
E
D
I
Q
E
Q
Site 28
T413
T
R
D
V
D
L
S
T
E
D
I
Q
E
Q
W
Site 29
S421
E
D
I
Q
E
Q
W
S
E
E
F
E
S
Q
P
Site 30
T429
E
E
F
E
S
Q
P
T
G
W
D
V
L
G
A
Site 31
T463
D
G
E
R
K
L
C
T
P
S
M
D
T
T
G
Site 32
S465
E
R
K
L
C
T
P
S
M
D
T
T
G
Y
G
Site 33
T469
C
T
P
S
M
D
T
T
G
Y
G
N
L
R
F
Site 34
Y471
P
S
M
D
T
T
G
Y
G
N
L
R
F
Y
F
Site 35
Y497
H
E
N
D
I
I
L
Y
A
K
I
E
G
R
K
Site 36
T508
E
G
R
K
E
H
I
T
L
D
T
L
S
Y
S
Site 37
T511
K
E
H
I
T
L
D
T
L
S
Y
S
S
Y
K
Site 38
S513
H
I
T
L
D
T
L
S
Y
S
S
Y
K
V
P
Site 39
S515
T
L
D
T
L
S
Y
S
S
Y
K
V
P
S
L
Site 40
Y517
D
T
L
S
Y
S
S
Y
K
V
P
S
L
V
S
Site 41
T582
S
I
N
L
G
C
G
T
H
Q
P
G
N
S
V
Site 42
S588
G
T
H
Q
P
G
N
S
V
S
L
E
F
S
T
Site 43
S590
H
Q
P
G
N
S
V
S
L
E
F
S
T
N
H
Site 44
S594
N
S
V
S
L
E
F
S
T
N
H
G
R
S
W
Site 45
T595
S
V
S
L
E
F
S
T
N
H
G
R
S
W
S
Site 46
S602
T
N
H
G
R
S
W
S
L
L
H
T
E
C
L
Site 47
T606
R
S
W
S
L
L
H
T
E
C
L
P
E
I
C
Site 48
S621
A
G
P
H
L
P
H
S
T
V
Y
S
S
E
N
Site 49
T622
G
P
H
L
P
H
S
T
V
Y
S
S
E
N
Y
Site 50
S625
L
P
H
S
T
V
Y
S
S
E
N
Y
S
G
W
Site 51
S626
P
H
S
T
V
Y
S
S
E
N
Y
S
G
W
N
Site 52
T636
Y
S
G
W
N
R
I
T
I
P
L
P
N
A
A
Site 53
T648
N
A
A
L
T
R
N
T
R
I
R
W
R
Q
T
Site 54
T655
T
R
I
R
W
R
Q
T
G
P
I
L
G
N
M
Site 55
S679
P
S
C
L
K
F
C
S
G
R
G
Q
C
T
R
Site 56
S712
Q
T
F
P
M
F
I
S
E
S
F
G
S
S
R
Site 57
S717
F
I
S
E
S
F
G
S
S
R
L
S
S
Y
H
Site 58
S718
I
S
E
S
F
G
S
S
R
L
S
S
Y
H
N
Site 59
S721
S
F
G
S
S
R
L
S
S
Y
H
N
F
Y
S
Site 60
S722
F
G
S
S
R
L
S
S
Y
H
N
F
Y
S
I
Site 61
Y723
G
S
S
R
L
S
S
Y
H
N
F
Y
S
I
R
Site 62
S728
S
S
Y
H
N
F
Y
S
I
R
G
A
E
V
S
Site 63
S735
S
I
R
G
A
E
V
S
F
G
C
G
V
L
A
Site 64
S743
F
G
C
G
V
L
A
S
G
K
A
L
V
F
N
Site 65
T759
D
G
R
R
Q
L
I
T
S
F
L
D
S
S
Q
Site 66
S760
G
R
R
Q
L
I
T
S
F
L
D
S
S
Q
S
Site 67
S764
L
I
T
S
F
L
D
S
S
Q
S
R
F
L
Q
Site 68
S765
I
T
S
F
L
D
S
S
Q
S
R
F
L
Q
F
Site 69
S767
S
F
L
D
S
S
Q
S
R
F
L
Q
F
T
L
Site 70
T773
Q
S
R
F
L
Q
F
T
L
R
L
G
S
K
S
Site 71
S780
T
L
R
L
G
S
K
S
V
L
S
T
C
R
A
Site 72
S783
L
G
S
K
S
V
L
S
T
C
R
A
P
D
Q
Site 73
T784
G
S
K
S
V
L
S
T
C
R
A
P
D
Q
P
Site 74
Y799
G
E
G
V
L
L
H
Y
S
Y
D
N
G
I
T
Site 75
Y801
G
V
L
L
H
Y
S
Y
D
N
G
I
T
W
K
Site 76
Y813
T
W
K
L
L
E
H
Y
S
Y
L
S
Y
H
E
Site 77
Y815
K
L
L
E
H
Y
S
Y
L
S
Y
H
E
P
R
Site 78
S817
L
E
H
Y
S
Y
L
S
Y
H
E
P
R
I
I
Site 79
Y818
E
H
Y
S
Y
L
S
Y
H
E
P
R
I
I
S
Site 80
S825
Y
H
E
P
R
I
I
S
V
E
L
P
G
D
A
Site 81
S906
T
L
C
F
T
G
D
S
K
L
A
S
S
M
R
Site 82
S910
T
G
D
S
K
L
A
S
S
M
R
Y
V
E
T
Site 83
S911
G
D
S
K
L
A
S
S
M
R
Y
V
E
T
Q
Site 84
Y914
K
L
A
S
S
M
R
Y
V
E
T
Q
S
M
Q
Site 85
S970
V
Q
E
E
C
L
P
S
M
P
S
C
Q
E
F
Site 86
S973
E
C
L
P
S
M
P
S
C
Q
E
F
T
S
A
Site 87
S979
P
S
C
Q
E
F
T
S
A
S
I
Y
H
A
S
Site 88
Y983
E
F
T
S
A
S
I
Y
H
A
S
E
F
T
Q
Site 89
S1005
L
P
Q
K
T
W
S
S
A
T
R
F
R
W
S
Site 90
S1012
S
A
T
R
F
R
W
S
Q
S
Y
Y
T
A
Q
Site 91
Y1015
R
F
R
W
S
Q
S
Y
Y
T
A
Q
D
E
W
Site 92
Y1016
F
R
W
S
Q
S
Y
Y
T
A
Q
D
E
W
A
Site 93
Y1028
E
W
A
L
D
S
I
Y
I
G
Q
Q
C
P
N
Site 94
S1067
H
P
E
A
A
L
P
S
T
I
M
S
D
F
E
Site 95
S1071
A
L
P
S
T
I
M
S
D
F
E
N
Q
N
G
Site 96
Y1108
I
S
S
G
S
S
L
Y
F
S
K
A
G
K
R
Site 97
S1110
S
G
S
S
L
Y
F
S
K
A
G
K
R
Q
L
Site 98
S1119
A
G
K
R
Q
L
V
S
W
D
L
D
T
S
W
Site 99
S1142
Q
I
G
G
E
S
A
S
C
N
K
P
D
S
R
Site 100
S1148
A
S
C
N
K
P
D
S
R
E
E
G
V
L
L
Site 101
Y1157
E
E
G
V
L
L
Q
Y
S
N
N
G
G
I
Q
Site 102
Y1172
W
H
L
L
A
E
M
Y
F
S
D
F
S
K
P
Site 103
S1174
L
L
A
E
M
Y
F
S
D
F
S
K
P
R
F
Site 104
T1192
E
L
P
A
A
A
K
T
P
C
T
R
F
R
W
Site 105
Y1209
P
V
F
S
G
E
D
Y
D
Q
W
A
V
D
D
Site 106
Y1240
P
T
L
P
Q
N
F
Y
E
K
P
A
F
D
Y
Site 107
Y1247
Y
E
K
P
A
F
D
Y
P
M
N
Q
M
S
V
Site 108
T1268
E
G
M
V
K
N
E
T
F
C
A
A
T
P
S
Site 109
T1273
N
E
T
F
C
A
A
T
P
S
A
M
I
F
G
Site 110
S1282
S
A
M
I
F
G
K
S
D
G
D
R
F
A
V
Site 111
Y1299
D
L
T
L
K
P
G
Y
V
L
Q
F
K
L
N
Site 112
Y1323
T
A
P
V
L
L
Q
Y
S
H
D
A
G
M
S
Site 113
Y1339
F
L
V
K
E
G
C
Y
P
A
S
A
G
K
G
Site 114
S1342
K
E
G
C
Y
P
A
S
A
G
K
G
C
E
G
Site 115
S1355
E
G
N
S
R
E
L
S
E
P
T
M
Y
H
T
Site 116
Y1360
E
L
S
E
P
T
M
Y
H
T
G
D
F
E
E
Site 117
S1382
I
P
R
S
L
A
S
S
K
T
R
F
R
W
I
Site 118
T1384
R
S
L
A
S
S
K
T
R
F
R
W
I
Q
E
Site 119
S1392
R
F
R
W
I
Q
E
S
S
S
Q
K
N
V
P
Site 120
S1394
R
W
I
Q
E
S
S
S
Q
K
N
V
P
P
F
Site 121
Y1415
I
S
E
P
C
P
S
Y
C
S
G
H
G
D
C
Site 122
S1459
D
R
F
E
G
K
L
S
P
L
W
Y
K
I
T
Site 123
Y1463
G
K
L
S
P
L
W
Y
K
I
T
G
A
Q
V
Site 124
T1466
S
P
L
W
Y
K
I
T
G
A
Q
V
G
T
G
Site 125
S1482
G
T
L
N
D
G
K
S
L
Y
F
N
G
P
G
Site 126
Y1484
L
N
D
G
K
S
L
Y
F
N
G
P
G
K
R
Site 127
T1495
P
G
K
R
E
A
R
T
V
P
L
D
T
R
N
Site 128
Y1535
N
E
G
L
I
V
Q
Y
S
N
D
N
G
I
L
Site 129
T1570
D
L
P
Q
D
A
K
T
P
A
T
A
F
R
W
Site 130
S1601
V
L
I
G
M
N
D
S
S
Q
T
G
F
Q
D
Site 131
S1602
L
I
G
M
N
D
S
S
Q
T
G
F
Q
D
K
Site 132
Y1621
I
D
L
Q
A
N
W
Y
R
I
Q
G
G
Q
V
Site 133
Y1650
E
N
I
G
K
P
R
Y
A
E
T
W
D
F
H
Site 134
S1677
M
G
C
S
K
P
F
S
N
S
H
S
V
Q
L
Site 135
S1679
C
S
K
P
F
S
N
S
H
S
V
Q
L
Q
Y
Site 136
S1681
K
P
F
S
N
S
H
S
V
Q
L
Q
Y
S
L
Site 137
T1698
G
K
D
W
H
L
V
T
E
E
C
V
P
P
T
Site 138
Y1711
P
T
I
G
C
L
H
Y
T
E
S
S
I
Y
T
Site 139
T1712
T
I
G
C
L
H
Y
T
E
S
S
I
Y
T
S
Site 140
S1714
G
C
L
H
Y
T
E
S
S
I
Y
T
S
E
R
Site 141
S1715
C
L
H
Y
T
E
S
S
I
Y
T
S
E
R
F
Site 142
Y1717
H
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A
V
D
K
Site 294
Y3363
D
K
A
V
L
L
Q
Y
S
V
N
N
G
I
T
Site 295
T3383
Q
H
Q
P
K
D
F
T
Q
A
Q
R
V
S
Y
Site 296
S3389
F
T
Q
A
Q
R
V
S
Y
N
V
P
L
E
A
Site 297
Y3390
T
Q
A
Q
R
V
S
Y
N
V
P
L
E
A
R
Site 298
Y3435
N
S
T
R
K
Q
N
Y
M
M
N
F
S
R
Q
Site 299
Y3449
Q
H
G
L
R
H
F
Y
N
R
R
R
R
S
L
Site 300
S3455
F
Y
N
R
R
R
R
S
L
R
R
Y
P
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation