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Updated November 2019
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Protein Info
Short Name:
ST5
Full Name:
Suppression of tumorigenicity 5 protein
Alias:
DENN domain-containing protein 2B; DENN/MADD domain containing 2B; DENND2B; HeLa tumor suppression 1; HTS1; p126; suppression of tumorigenicity 5
Type:
Unknown function
Mass (Da):
126499
Number AA:
1137
UniProt ID:
P78524
International Prot ID:
IPI00162743
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S10
M
T
A
N
K
N
S
S
I
T
H
G
A
G
G
Site 2
T12
A
N
K
N
S
S
I
T
H
G
A
G
G
T
K
Site 3
T18
I
T
H
G
A
G
G
T
K
A
P
R
G
T
L
Site 4
T24
G
T
K
A
P
R
G
T
L
S
R
S
Q
S
V
Site 5
S26
K
A
P
R
G
T
L
S
R
S
Q
S
V
S
P
Site 6
S28
P
R
G
T
L
S
R
S
Q
S
V
S
P
P
P
Site 7
S30
G
T
L
S
R
S
Q
S
V
S
P
P
P
V
L
Site 8
S32
L
S
R
S
Q
S
V
S
P
P
P
V
L
S
P
Site 9
S38
V
S
P
P
P
V
L
S
P
P
R
S
P
I
Y
Site 10
S42
P
V
L
S
P
P
R
S
P
I
Y
P
L
S
D
Site 11
Y45
S
P
P
R
S
P
I
Y
P
L
S
D
S
E
T
Site 12
S48
R
S
P
I
Y
P
L
S
D
S
E
T
S
A
C
Site 13
S50
P
I
Y
P
L
S
D
S
E
T
S
A
C
R
Y
Site 14
T52
Y
P
L
S
D
S
E
T
S
A
C
R
Y
P
S
Site 15
S53
P
L
S
D
S
E
T
S
A
C
R
Y
P
S
H
Site 16
Y57
S
E
T
S
A
C
R
Y
P
S
H
S
S
S
R
Site 17
S59
T
S
A
C
R
Y
P
S
H
S
S
S
R
V
L
Site 18
S61
A
C
R
Y
P
S
H
S
S
S
R
V
L
L
K
Site 19
S62
C
R
Y
P
S
H
S
S
S
R
V
L
L
K
D
Site 20
S63
R
Y
P
S
H
S
S
S
R
V
L
L
K
D
R
Site 21
S76
D
R
H
P
P
A
P
S
P
Q
N
P
Q
D
P
Site 22
S84
P
Q
N
P
Q
D
P
S
P
D
T
S
P
P
T
Site 23
T87
P
Q
D
P
S
P
D
T
S
P
P
T
C
P
F
Site 24
S88
Q
D
P
S
P
D
T
S
P
P
T
C
P
F
K
Site 25
T91
S
P
D
T
S
P
P
T
C
P
F
K
T
A
S
Site 26
T96
P
P
T
C
P
F
K
T
A
S
F
G
Y
L
D
Site 27
S98
T
C
P
F
K
T
A
S
F
G
Y
L
D
R
S
Site 28
Y101
F
K
T
A
S
F
G
Y
L
D
R
S
P
S
A
Site 29
S105
S
F
G
Y
L
D
R
S
P
S
A
C
K
R
D
Site 30
S107
G
Y
L
D
R
S
P
S
A
C
K
R
D
A
Q
Site 31
T153
G
P
R
G
V
L
L
T
R
T
G
T
R
A
H
Site 32
T155
R
G
V
L
L
T
R
T
G
T
R
A
H
S
L
Site 33
S161
R
T
G
T
R
A
H
S
L
G
I
R
E
K
I
Site 34
S178
W
E
G
R
R
E
A
S
P
R
M
S
M
C
G
Site 35
S182
R
E
A
S
P
R
M
S
M
C
G
E
K
R
E
Site 36
S191
C
G
E
K
R
E
G
S
G
S
E
W
A
A
S
Site 37
S193
E
K
R
E
G
S
G
S
E
W
A
A
S
E
G
Site 38
S198
S
G
S
E
W
A
A
S
E
G
C
P
S
L
G
Site 39
S203
A
A
S
E
G
C
P
S
L
G
C
P
S
V
V
Site 40
S212
G
C
P
S
V
V
P
S
P
C
S
S
E
K
T
Site 41
S215
S
V
V
P
S
P
C
S
S
E
K
T
F
D
F
Site 42
S216
V
V
P
S
P
C
S
S
E
K
T
F
D
F
K
Site 43
T219
S
P
C
S
S
E
K
T
F
D
F
K
G
L
R
Site 44
S229
F
K
G
L
R
R
M
S
R
T
F
S
E
C
S
Site 45
T231
G
L
R
R
M
S
R
T
F
S
E
C
S
Y
P
Site 46
S233
R
R
M
S
R
T
F
S
E
C
S
Y
P
E
T
Site 47
S236
S
R
T
F
S
E
C
S
Y
P
E
T
E
E
E
Site 48
Y237
R
T
F
S
E
C
S
Y
P
E
T
E
E
E
G
Site 49
T240
S
E
C
S
Y
P
E
T
E
E
E
G
E
A
L
Site 50
S252
E
A
L
P
V
R
D
S
F
Y
R
L
E
K
R
Site 51
Y254
L
P
V
R
D
S
F
Y
R
L
E
K
R
L
G
Site 52
S266
R
L
G
R
S
E
P
S
A
F
L
R
G
H
G
Site 53
S274
A
F
L
R
G
H
G
S
R
K
E
S
S
A
V
Site 54
S278
G
H
G
S
R
K
E
S
S
A
V
L
S
R
I
Site 55
S279
H
G
S
R
K
E
S
S
A
V
L
S
R
I
Q
Site 56
S283
K
E
S
S
A
V
L
S
R
I
Q
K
I
E
Q
Site 57
S305
R
G
L
P
Q
L
P
S
S
C
Y
S
V
D
R
Site 58
S306
G
L
P
Q
L
P
S
S
C
Y
S
V
D
R
G
Site 59
Y308
P
Q
L
P
S
S
C
Y
S
V
D
R
G
K
R
Site 60
S309
Q
L
P
S
S
C
Y
S
V
D
R
G
K
R
K
Site 61
T317
V
D
R
G
K
R
K
T
G
T
L
G
S
L
E
Site 62
T319
R
G
K
R
K
T
G
T
L
G
S
L
E
E
P
Site 63
S322
R
K
T
G
T
L
G
S
L
E
E
P
A
G
G
Site 64
S331
E
E
P
A
G
G
A
S
V
S
A
G
S
R
A
Site 65
S357
P
P
P
E
R
E
G
S
G
S
T
K
P
G
T
Site 66
S359
P
E
R
E
G
S
G
S
T
K
P
G
T
P
G
Site 67
T360
E
R
E
G
S
G
S
T
K
P
G
T
P
G
N
Site 68
T364
S
G
S
T
K
P
G
T
P
G
N
S
P
S
S
Site 69
S368
K
P
G
T
P
G
N
S
P
S
S
Q
R
L
P
Site 70
S370
G
T
P
G
N
S
P
S
S
Q
R
L
P
S
K
Site 71
S371
T
P
G
N
S
P
S
S
Q
R
L
P
S
K
S
Site 72
S376
P
S
S
Q
R
L
P
S
K
S
S
L
D
P
A
Site 73
S378
S
Q
R
L
P
S
K
S
S
L
D
P
A
V
N
Site 74
S379
Q
R
L
P
S
K
S
S
L
D
P
A
V
N
P
Site 75
T393
P
V
P
K
P
K
R
T
F
E
Y
E
A
E
K
Site 76
Y396
K
P
K
R
T
F
E
Y
E
A
E
K
N
P
K
Site 77
S404
E
A
E
K
N
P
K
S
K
P
S
N
G
L
P
Site 78
S407
K
N
P
K
S
K
P
S
N
G
L
P
P
S
P
Site 79
S413
P
S
N
G
L
P
P
S
P
T
P
A
A
P
P
Site 80
T415
N
G
L
P
P
S
P
T
P
A
A
P
P
P
L
Site 81
S424
A
A
P
P
P
L
P
S
T
P
A
P
P
V
T
Site 82
T425
A
P
P
P
L
P
S
T
P
A
P
P
V
T
R
Site 83
T431
S
T
P
A
P
P
V
T
R
R
P
K
K
D
M
Site 84
S444
D
M
R
G
H
R
K
S
Q
S
R
K
S
F
E
Site 85
S446
R
G
H
R
K
S
Q
S
R
K
S
F
E
F
E
Site 86
S449
R
K
S
Q
S
R
K
S
F
E
F
E
D
A
S
Site 87
S456
S
F
E
F
E
D
A
S
S
L
Q
S
L
Y
P
Site 88
S457
F
E
F
E
D
A
S
S
L
Q
S
L
Y
P
S
Site 89
S460
E
D
A
S
S
L
Q
S
L
Y
P
S
S
P
T
Site 90
Y462
A
S
S
L
Q
S
L
Y
P
S
S
P
T
E
N
Site 91
S464
S
L
Q
S
L
Y
P
S
S
P
T
E
N
G
T
Site 92
S465
L
Q
S
L
Y
P
S
S
P
T
E
N
G
T
E
Site 93
S481
Q
P
K
F
G
S
K
S
T
L
E
E
N
A
Y
Site 94
Y488
S
T
L
E
E
N
A
Y
E
D
I
V
G
D
L
Site 95
Y501
D
L
P
K
E
N
P
Y
E
D
V
D
L
K
S
Site 96
S508
Y
E
D
V
D
L
K
S
R
R
A
G
R
K
S
Site 97
S515
S
R
R
A
G
R
K
S
Q
Q
L
S
E
N
S
Site 98
S519
G
R
K
S
Q
Q
L
S
E
N
S
L
D
S
L
Site 99
S522
S
Q
Q
L
S
E
N
S
L
D
S
L
H
R
M
Site 100
S525
L
S
E
N
S
L
D
S
L
H
R
M
W
S
P
Site 101
S531
D
S
L
H
R
M
W
S
P
Q
D
R
K
Y
N
Site 102
Y537
W
S
P
Q
D
R
K
Y
N
S
P
P
T
Q
L
Site 103
S539
P
Q
D
R
K
Y
N
S
P
P
T
Q
L
S
L
Site 104
S545
N
S
P
P
T
Q
L
S
L
K
P
N
S
Q
S
Site 105
S550
Q
L
S
L
K
P
N
S
Q
S
L
R
S
G
N
Site 106
S552
S
L
K
P
N
S
Q
S
L
R
S
G
N
W
S
Site 107
S555
P
N
S
Q
S
L
R
S
G
N
W
S
E
R
K
Site 108
S559
S
L
R
S
G
N
W
S
E
R
K
S
H
R
L
Site 109
S563
G
N
W
S
E
R
K
S
H
R
L
P
R
L
P
Site 110
S574
P
R
L
P
K
R
H
S
H
D
D
M
L
L
L
Site 111
S588
L
A
Q
L
S
L
P
S
S
P
S
S
L
N
E
Site 112
S589
A
Q
L
S
L
P
S
S
P
S
S
L
N
E
D
Site 113
S591
L
S
L
P
S
S
P
S
S
L
N
E
D
S
L
Site 114
S592
S
L
P
S
S
P
S
S
L
N
E
D
S
L
S
Site 115
S597
P
S
S
L
N
E
D
S
L
S
T
T
S
E
L
Site 116
S599
S
L
N
E
D
S
L
S
T
T
S
E
L
L
S
Site 117
T601
N
E
D
S
L
S
T
T
S
E
L
L
S
S
R
Site 118
S602
E
D
S
L
S
T
T
S
E
L
L
S
S
R
R
Site 119
S606
S
T
T
S
E
L
L
S
S
R
R
A
R
R
I
Site 120
S607
T
T
S
E
L
L
S
S
R
R
A
R
R
I
P
Site 121
S622
K
L
V
Q
R
I
N
S
I
Y
N
A
K
R
G
Site 122
Y624
V
Q
R
I
N
S
I
Y
N
A
K
R
G
K
K
Site 123
S637
K
K
R
L
K
K
L
S
M
S
S
I
E
T
A
Site 124
S639
R
L
K
K
L
S
M
S
S
I
E
T
A
S
L
Site 125
S640
L
K
K
L
S
M
S
S
I
E
T
A
S
L
R
Site 126
T643
L
S
M
S
S
I
E
T
A
S
L
R
D
E
N
Site 127
S645
M
S
S
I
E
T
A
S
L
R
D
E
N
S
E
Site 128
S651
A
S
L
R
D
E
N
S
E
S
E
S
D
S
D
Site 129
S653
L
R
D
E
N
S
E
S
E
S
D
S
D
D
R
Site 130
S655
D
E
N
S
E
S
E
S
D
S
D
D
R
F
K
Site 131
S657
N
S
E
S
E
S
D
S
D
D
R
F
K
A
H
Site 132
T665
D
D
R
F
K
A
H
T
Q
R
L
V
H
I
Q
Site 133
S673
Q
R
L
V
H
I
Q
S
M
L
K
R
A
P
S
Site 134
S680
S
M
L
K
R
A
P
S
Y
R
T
L
E
L
E
Site 135
Y699
Q
E
R
E
L
F
E
Y
F
V
V
V
S
L
K
Site 136
S704
F
E
Y
F
V
V
V
S
L
K
K
K
P
S
R
Site 137
S710
V
S
L
K
K
K
P
S
R
N
T
Y
L
P
E
Site 138
T713
K
K
K
P
S
R
N
T
Y
L
P
E
V
S
Y
Site 139
Y714
K
K
P
S
R
N
T
Y
L
P
E
V
S
Y
Q
Site 140
Y720
T
Y
L
P
E
V
S
Y
Q
F
P
K
L
D
R
Site 141
T729
F
P
K
L
D
R
P
T
K
Q
M
R
E
A
E
Site 142
S757
A
K
D
W
L
P
V
S
E
Y
S
S
E
T
F
Site 143
Y759
D
W
L
P
V
S
E
Y
S
S
E
T
F
S
F
Site 144
S760
W
L
P
V
S
E
Y
S
S
E
T
F
S
F
M
Site 145
T763
V
S
E
Y
S
S
E
T
F
S
F
M
L
T
G
Site 146
S765
E
Y
S
S
E
T
F
S
F
M
L
T
G
E
D
Site 147
T769
E
T
F
S
F
M
L
T
G
E
D
G
S
R
R
Site 148
S774
M
L
T
G
E
D
G
S
R
R
F
G
Y
C
R
Site 149
Y779
D
G
S
R
R
F
G
Y
C
R
R
L
L
P
S
Site 150
S786
Y
C
R
R
L
L
P
S
G
K
G
P
R
L
P
Site 151
S836
F
M
R
S
L
M
E
S
P
F
P
A
P
G
K
Site 152
T849
G
K
T
I
K
V
K
T
F
L
P
G
A
G
N
Site 153
S867
E
L
R
R
P
M
D
S
R
L
E
H
V
D
F
Site 154
T986
R
Q
M
D
D
E
D
T
L
L
P
R
K
L
Q
Site 155
S1008
E
R
K
N
E
L
I
S
Q
D
S
D
S
D
S
Site 156
S1011
N
E
L
I
S
Q
D
S
D
S
D
S
D
D
E
Site 157
S1013
L
I
S
Q
D
S
D
S
D
S
D
D
E
C
N
Site 158
S1015
S
Q
D
S
D
S
D
S
D
D
E
C
N
T
L
Site 159
Y1041
F
V
E
T
V
G
H
Y
S
L
F
L
T
Q
S
Site 160
S1042
V
E
T
V
G
H
Y
S
L
F
L
T
Q
S
E
Site 161
T1046
G
H
Y
S
L
F
L
T
Q
S
E
K
G
E
R
Site 162
S1048
Y
S
L
F
L
T
Q
S
E
K
G
E
R
A
F
Site 163
S1063
Q
R
E
A
F
R
K
S
V
A
S
K
S
I
R
Site 164
S1066
A
F
R
K
S
V
A
S
K
S
I
R
R
F
L
Site 165
S1068
R
K
S
V
A
S
K
S
I
R
R
F
L
E
V
Site 166
T1114
Y
L
E
E
L
P
D
T
E
Q
S
G
M
N
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation