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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ADAM17
Full Name:
Disintegrin and metalloproteinase domain-containing protein 17
Alias:
Disintegrin and metalloproteinase domain-containing protein 17; Snake venom-like protease; TNF-alpha convertase; TNF-alpha-converting enzyme
Type:
Protease
Mass (Da):
93021
Number AA:
824
UniProt ID:
P78536
International Prot ID:
IPI00288894
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0015629
GO:0016324
GO:0009986
Uniprot
OncoNet
Molecular Function:
GO:0030165
GO:0017124
GO:0005178
PhosphoSite+
KinaseNET
Biological Process:
GO:0030183
GO:0007219
GO:0051088
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S37
Q
R
L
E
K
L
D
S
L
L
S
D
Y
D
I
Site 2
S40
E
K
L
D
S
L
L
S
D
Y
D
I
L
S
L
Site 3
S46
L
S
D
Y
D
I
L
S
L
S
N
I
Q
Q
H
Site 4
S48
D
Y
D
I
L
S
L
S
N
I
Q
Q
H
S
V
Site 5
S54
L
S
N
I
Q
Q
H
S
V
R
K
R
D
L
Q
Site 6
S63
R
K
R
D
L
Q
T
S
T
H
V
E
T
L
L
Site 7
T71
T
H
V
E
T
L
L
T
F
S
A
L
K
R
H
Site 8
Y82
L
K
R
H
F
K
L
Y
L
T
S
S
T
E
R
Site 9
T84
R
H
F
K
L
Y
L
T
S
S
T
E
R
F
S
Site 10
S86
F
K
L
Y
L
T
S
S
T
E
R
F
S
Q
N
Site 11
T87
K
L
Y
L
T
S
S
T
E
R
F
S
Q
N
F
Site 12
S91
T
S
S
T
E
R
F
S
Q
N
F
K
V
V
V
Site 13
Y107
D
G
K
N
E
S
E
Y
T
V
K
W
Q
D
F
Site 14
T116
V
K
W
Q
D
F
F
T
G
H
V
V
G
E
P
Site 15
S125
H
V
V
G
E
P
D
S
R
V
L
A
H
I
R
Site 16
T142
D
V
I
I
R
I
N
T
D
G
A
E
Y
N
I
Site 17
T159
L
W
R
F
V
N
D
T
K
D
K
R
M
L
V
Site 18
S169
K
R
M
L
V
Y
K
S
E
D
I
K
N
V
S
Site 19
S176
S
E
D
I
K
N
V
S
R
L
Q
S
P
K
V
Site 20
S180
K
N
V
S
R
L
Q
S
P
K
V
C
G
Y
L
Site 21
Y379
P
V
G
K
K
N
I
Y
L
N
S
G
L
T
S
Site 22
S382
K
K
N
I
Y
L
N
S
G
L
T
S
T
K
N
Site 23
Y433
N
E
D
Q
G
G
K
Y
V
M
Y
P
I
A
V
Site 24
Y436
Q
G
G
K
Y
V
M
Y
P
I
A
V
S
G
D
Site 25
Y702
D
K
K
L
D
K
Q
Y
E
S
L
S
L
F
H
Site 26
S704
K
L
D
K
Q
Y
E
S
L
S
L
F
H
P
S
Site 27
S706
D
K
Q
Y
E
S
L
S
L
F
H
P
S
N
V
Site 28
S711
S
L
S
L
F
H
P
S
N
V
E
M
L
S
S
Site 29
S717
P
S
N
V
E
M
L
S
S
M
D
S
A
S
V
Site 30
S718
S
N
V
E
M
L
S
S
M
D
S
A
S
V
R
Site 31
T735
K
P
F
P
A
P
Q
T
P
G
R
L
Q
P
A
Site 32
T761
L
D
H
Q
R
M
D
T
I
Q
E
D
P
S
T
Site 33
S767
D
T
I
Q
E
D
P
S
T
D
S
H
M
D
E
Site 34
T768
T
I
Q
E
D
P
S
T
D
S
H
M
D
E
D
Site 35
S770
Q
E
D
P
S
T
D
S
H
M
D
E
D
G
F
Site 36
S785
E
K
D
P
F
P
N
S
S
T
A
A
K
S
F
Site 37
S786
K
D
P
F
P
N
S
S
T
A
A
K
S
F
E
Site 38
T787
D
P
F
P
N
S
S
T
A
A
K
S
F
E
D
Site 39
S791
N
S
S
T
A
A
K
S
F
E
D
L
T
D
H
Site 40
T796
A
K
S
F
E
D
L
T
D
H
P
V
T
R
S
Site 41
S803
T
D
H
P
V
T
R
S
E
K
A
A
S
F
K
Site 42
S808
T
R
S
E
K
A
A
S
F
K
L
Q
R
Q
N
Site 43
S819
Q
R
Q
N
R
V
D
S
K
E
T
E
C
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation