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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
NTHL1
Full Name:
Endonuclease III-like protein 1
Alias:
endonuclease III-like 1; nth endonuclease III-like 1; NTH1; OCTS3
Type:
EC 4.2.99.18; Lyase; DNA repair; Hydrolase; Mitochondrial
Mass (Da):
34390
Number AA:
312
UniProt ID:
P78549
International Prot ID:
IPI00001722
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005654
GO:0005634
GO:0005654
Uniprot
OncoNet
Molecular Function:
GO:0051539
GO:0003690
GO:0004519
PhosphoSite+
KinaseNET
Biological Process:
GO:0045008
GO:0006296
GO:0006220
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S7
_
M
C
S
P
Q
E
S
G
M
T
A
L
S
A
Site 2
T10
S
P
Q
E
S
G
M
T
A
L
S
A
R
M
L
Site 3
S13
E
S
G
M
T
A
L
S
A
R
M
L
T
R
S
Site 4
T18
A
L
S
A
R
M
L
T
R
S
R
S
L
G
P
Site 5
S20
S
A
R
M
L
T
R
S
R
S
L
G
P
G
A
Site 6
S22
R
M
L
T
R
S
R
S
L
G
P
G
A
G
P
Site 7
S51
A
A
A
E
A
R
K
S
H
S
P
V
K
R
P
Site 8
S53
A
E
A
R
K
S
H
S
P
V
K
R
P
R
K
Site 9
Y68
A
Q
R
L
R
V
A
Y
E
G
S
D
S
E
K
Site 10
S71
L
R
V
A
Y
E
G
S
D
S
E
K
G
E
G
Site 11
S73
V
A
Y
E
G
S
D
S
E
K
G
E
G
A
E
Site 12
Y119
H
L
G
T
E
H
C
Y
D
S
S
A
P
P
K
Site 13
S122
T
E
H
C
Y
D
S
S
A
P
P
K
V
R
R
Site 14
S135
R
R
Y
Q
V
L
L
S
L
M
L
S
S
Q
T
Site 15
T147
S
Q
T
K
D
Q
V
T
A
G
A
M
Q
R
L
Site 16
T160
R
L
R
A
R
G
L
T
V
D
S
I
L
Q
T
Site 17
S163
A
R
G
L
T
V
D
S
I
L
Q
T
D
D
A
Site 18
T167
T
V
D
S
I
L
Q
T
D
D
A
T
L
G
K
Site 19
T171
I
L
Q
T
D
D
A
T
L
G
K
L
I
Y
P
Site 20
Y188
F
W
R
S
K
V
K
Y
I
K
Q
T
S
A
I
Site 21
Y200
S
A
I
L
Q
Q
H
Y
G
G
D
I
P
A
S
Site 22
T252
I
A
N
R
L
R
W
T
K
K
A
T
K
S
P
Site 23
S258
W
T
K
K
A
T
K
S
P
E
E
T
R
A
A
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation