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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MAP1A
Full Name:
Microtubule-associated protein 1A
Alias:
MAP 1A; MAP1L; MAPA; MTAP1; MTAP1A; Proliferation-related protein p80
Type:
Cytoskeletal protein - Microtubule dynamics
Mass (Da):
305627
Number AA:
2805
UniProt ID:
P78559
International Prot ID:
IPI00789977
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005874
GO:0005875
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0005198
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S8
M
D
G
V
A
E
F
S
E
Y
V
S
E
T
V
Site 2
S12
A
E
F
S
E
Y
V
S
E
T
V
D
V
P
S
Site 3
T14
F
S
E
Y
V
S
E
T
V
D
V
P
S
P
F
Site 4
S19
S
E
T
V
D
V
P
S
P
F
D
L
L
E
P
Site 5
S29
D
L
L
E
P
P
T
S
G
G
F
L
K
L
S
Site 6
Y41
K
L
S
K
P
C
C
Y
I
F
P
G
G
R
G
Site 7
S66
N
I
L
V
D
G
G
S
D
R
K
S
C
F
W
Site 8
S70
D
G
G
S
D
R
K
S
C
F
W
K
L
V
R
Site 9
S84
R
H
L
D
R
I
D
S
V
L
L
T
H
I
G
Site 10
S114
A
E
L
E
E
E
Q
S
Q
G
S
S
S
Y
S
Site 11
S117
E
E
E
Q
S
Q
G
S
S
S
Y
S
D
W
V
Site 12
S118
E
E
Q
S
Q
G
S
S
S
Y
S
D
W
V
K
Site 13
S119
E
Q
S
Q
G
S
S
S
Y
S
D
W
V
K
N
Site 14
Y120
Q
S
Q
G
S
S
S
Y
S
D
W
V
K
N
L
Site 15
S121
S
Q
G
S
S
S
Y
S
D
W
V
K
N
L
I
Site 16
S149
K
L
R
L
P
D
A
S
R
K
A
K
R
S
I
Site 17
S155
A
S
R
K
A
K
R
S
I
E
E
A
C
L
T
Site 18
T162
S
I
E
E
A
C
L
T
L
Q
H
L
N
R
L
Site 19
Y177
G
I
Q
A
E
P
L
Y
R
V
V
S
N
T
I
Site 20
S181
E
P
L
Y
R
V
V
S
N
T
I
E
P
L
T
Site 21
Y201
G
V
G
R
L
D
M
Y
V
L
N
P
V
K
D
Site 22
S209
V
L
N
P
V
K
D
S
K
E
M
Q
F
L
M
Site 23
S223
M
Q
K
W
A
G
N
S
K
A
K
T
G
I
V
Site 24
T227
A
G
N
S
K
A
K
T
G
I
V
L
P
N
G
Site 25
S240
N
G
K
E
A
E
I
S
V
P
Y
L
T
S
I
Site 26
T259
V
W
L
P
A
N
P
T
E
K
I
V
R
V
L
Site 27
Y291
R
H
L
D
F
L
R
Y
P
V
A
T
Q
K
D
Site 28
T295
F
L
R
Y
P
V
A
T
Q
K
D
L
A
S
G
Site 29
S301
A
T
Q
K
D
L
A
S
G
A
V
P
T
N
L
Site 30
S319
K
I
K
Q
R
A
D
S
K
E
S
L
K
A
T
Site 31
S322
Q
R
A
D
S
K
E
S
L
K
A
T
T
K
T
Site 32
T326
S
K
E
S
L
K
A
T
T
K
T
A
V
S
K
Site 33
T329
S
L
K
A
T
T
K
T
A
V
S
K
L
A
K
Site 34
T359
L
A
K
E
L
A
K
T
E
K
K
A
K
E
S
Site 35
T382
A
K
P
E
R
V
K
T
E
S
S
E
A
L
K
Site 36
S384
P
E
R
V
K
T
E
S
S
E
A
L
K
A
E
Site 37
S385
E
R
V
K
T
E
S
S
E
A
L
K
A
E
K
Site 38
S410
K
H
L
K
E
K
I
S
K
L
E
E
K
K
D
Site 39
T452
K
E
E
K
R
K
D
T
K
P
E
L
K
K
I
Site 40
S460
K
P
E
L
K
K
I
S
K
P
D
L
K
P
F
Site 41
T468
K
P
D
L
K
P
F
T
P
E
V
R
K
T
L
Site 42
T474
F
T
P
E
V
R
K
T
L
Y
K
A
K
V
P
Site 43
Y476
P
E
V
R
K
T
L
Y
K
A
K
V
P
G
R
Site 44
S489
G
R
V
K
I
D
R
S
R
A
I
R
G
E
K
Site 45
S499
I
R
G
E
K
E
L
S
S
E
P
Q
T
P
P
Site 46
S500
R
G
E
K
E
L
S
S
E
P
Q
T
P
P
A
Site 47
T504
E
L
S
S
E
P
Q
T
P
P
A
Q
K
G
T
Site 48
T516
K
G
T
V
P
L
P
T
I
S
G
H
R
E
L
Site 49
S526
G
H
R
E
L
V
L
S
S
P
E
D
L
T
Q
Site 50
S527
H
R
E
L
V
L
S
S
P
E
D
L
T
Q
D
Site 51
T532
L
S
S
P
E
D
L
T
Q
D
F
E
E
M
K
Site 52
T552
L
L
A
E
Q
R
D
T
G
L
G
D
K
P
F
Site 53
T563
D
K
P
F
P
L
D
T
A
E
E
G
P
P
S
Site 54
S570
T
A
E
E
G
P
P
S
T
A
I
Q
G
T
P
Site 55
T571
A
E
E
G
P
P
S
T
A
I
Q
G
T
P
P
Site 56
T576
P
S
T
A
I
Q
G
T
P
P
S
V
P
G
L
Site 57
S579
A
I
Q
G
T
P
P
S
V
P
G
L
G
Q
E
Site 58
S605
E
V
P
E
E
Q
G
S
K
D
R
G
L
D
S
Site 59
S612
S
K
D
R
G
L
D
S
G
A
E
T
E
E
E
Site 60
T616
G
L
D
S
G
A
E
T
E
E
E
K
D
T
W
Site 61
T622
E
T
E
E
E
K
D
T
W
E
E
K
K
Q
R
Site 62
T638
A
E
R
L
P
D
R
T
E
A
R
E
E
S
E
Site 63
S644
R
T
E
A
R
E
E
S
E
P
E
V
K
E
D
Site 64
S667
E
M
E
E
V
H
P
S
D
E
E
E
E
D
A
Site 65
T675
D
E
E
E
E
D
A
T
K
A
E
G
F
Y
Q
Site 66
Y681
A
T
K
A
E
G
F
Y
Q
K
H
M
Q
E
P
Site 67
T692
M
Q
E
P
L
K
V
T
P
R
S
R
E
A
F
Site 68
S695
P
L
K
V
T
P
R
S
R
E
A
F
G
G
R
Site 69
S716
K
A
P
E
K
E
T
S
L
F
L
S
S
L
T
Site 70
S720
K
E
T
S
L
F
L
S
S
L
T
T
P
A
G
Site 71
Y734
G
A
T
E
H
V
S
Y
I
Q
D
E
T
I
P
Site 72
T749
G
Y
S
E
T
E
Q
T
I
S
D
E
E
I
H
Site 73
S751
S
E
T
E
Q
T
I
S
D
E
E
I
H
D
E
Site 74
T770
P
A
P
P
R
F
H
T
S
T
Y
D
L
P
G
Site 75
S771
A
P
P
R
F
H
T
S
T
Y
D
L
P
G
P
Site 76
T772
P
P
R
F
H
T
S
T
Y
D
L
P
G
P
E
Site 77
Y773
P
R
F
H
T
S
T
Y
D
L
P
G
P
E
G
Site 78
S787
G
A
G
P
F
E
A
S
Q
P
A
D
S
A
V
Site 79
S792
E
A
S
Q
P
A
D
S
A
V
P
A
T
S
G
Site 80
Y802
P
A
T
S
G
K
V
Y
G
T
P
E
T
E
L
Site 81
T804
T
S
G
K
V
Y
G
T
P
E
T
E
L
T
Y
Site 82
T810
G
T
P
E
T
E
L
T
Y
P
T
N
I
V
A
Site 83
Y811
T
P
E
T
E
L
T
Y
P
T
N
I
V
A
A
Site 84
S827
L
A
E
E
E
H
V
S
S
A
T
S
I
T
E
Site 85
S828
A
E
E
E
H
V
S
S
A
T
S
I
T
E
C
Site 86
S831
E
H
V
S
S
A
T
S
I
T
E
C
D
K
L
Site 87
T833
V
S
S
A
T
S
I
T
E
C
D
K
L
S
S
Site 88
S840
T
E
C
D
K
L
S
S
F
A
T
S
V
A
E
Site 89
T843
D
K
L
S
S
F
A
T
S
V
A
E
D
Q
S
Site 90
S844
K
L
S
S
F
A
T
S
V
A
E
D
Q
S
V
Site 91
S850
T
S
V
A
E
D
Q
S
V
A
S
L
T
A
P
Site 92
T859
A
S
L
T
A
P
Q
T
E
E
T
G
K
S
S
Site 93
T862
T
A
P
Q
T
E
E
T
G
K
S
S
L
L
L
Site 94
S865
Q
T
E
E
T
G
K
S
S
L
L
L
D
T
V
Site 95
S874
L
L
L
D
T
V
T
S
I
P
S
S
R
T
E
Site 96
S877
D
T
V
T
S
I
P
S
S
R
T
E
A
T
Q
Site 97
S878
T
V
T
S
I
P
S
S
R
T
E
A
T
Q
G
Site 98
Y888
E
A
T
Q
G
L
D
Y
V
P
S
A
G
T
I
Site 99
S891
Q
G
L
D
Y
V
P
S
A
G
T
I
S
P
T
Site 100
T894
D
Y
V
P
S
A
G
T
I
S
P
T
S
S
L
Site 101
S896
V
P
S
A
G
T
I
S
P
T
S
S
L
E
E
Site 102
T898
S
A
G
T
I
S
P
T
S
S
L
E
E
D
K
Site 103
S899
A
G
T
I
S
P
T
S
S
L
E
E
D
K
G
Site 104
S900
G
T
I
S
P
T
S
S
L
E
E
D
K
G
F
Site 105
S909
E
E
D
K
G
F
K
S
P
P
C
E
D
F
S
Site 106
S916
S
P
P
C
E
D
F
S
V
T
G
E
S
E
K
Site 107
T918
P
C
E
D
F
S
V
T
G
E
S
E
K
R
G
Site 108
S933
E
I
I
G
K
G
L
S
G
E
R
A
V
E
E
Site 109
T945
V
E
E
E
E
E
E
T
A
N
V
E
M
S
E
Site 110
S951
E
T
A
N
V
E
M
S
E
K
L
C
S
Q
Y
Site 111
S956
E
M
S
E
K
L
C
S
Q
Y
G
T
P
V
F
Site 112
Y958
S
E
K
L
C
S
Q
Y
G
T
P
V
F
S
A
Site 113
T960
K
L
C
S
Q
Y
G
T
P
V
F
S
A
P
G
Site 114
S964
Q
Y
G
T
P
V
F
S
A
P
G
H
A
L
H
Site 115
S986
E
A
E
E
R
C
L
S
P
D
D
S
T
V
K
Site 116
S990
R
C
L
S
P
D
D
S
T
V
K
M
A
S
P
Site 117
T991
C
L
S
P
D
D
S
T
V
K
M
A
S
P
P
Site 118
S996
D
S
T
V
K
M
A
S
P
P
P
S
G
P
P
Site 119
S1000
K
M
A
S
P
P
P
S
G
P
P
S
A
T
H
Site 120
S1004
P
P
P
S
G
P
P
S
A
T
H
T
P
F
H
Site 121
T1006
P
S
G
P
P
S
A
T
H
T
P
F
H
Q
S
Site 122
T1008
G
P
P
S
A
T
H
T
P
F
H
Q
S
P
V
Site 123
S1013
T
H
T
P
F
H
Q
S
P
V
E
E
K
S
E
Site 124
S1019
Q
S
P
V
E
E
K
S
E
P
Q
D
F
Q
E
Site 125
S1029
Q
D
F
Q
E
A
D
S
W
G
D
T
K
R
T
Site 126
T1033
E
A
D
S
W
G
D
T
K
R
T
P
G
V
G
Site 127
T1036
S
W
G
D
T
K
R
T
P
G
V
G
K
E
D
Site 128
T1048
K
E
D
A
A
E
E
T
V
K
P
G
P
E
E
Site 129
S1069
E
K
V
P
P
P
R
S
P
Q
A
Q
E
A
P
Site 130
T1124
A
L
P
G
G
L
R
T
L
P
Q
E
P
G
K
Site 131
Y1140
Q
K
D
E
V
L
R
Y
P
D
R
S
L
S
P
Site 132
S1144
V
L
R
Y
P
D
R
S
L
S
P
E
D
A
E
Site 133
S1146
R
Y
P
D
R
S
L
S
P
E
D
A
E
S
L
Site 134
S1152
L
S
P
E
D
A
E
S
L
S
V
L
S
V
P
Site 135
S1154
P
E
D
A
E
S
L
S
V
L
S
V
P
S
P
Site 136
S1157
A
E
S
L
S
V
L
S
V
P
S
P
D
T
A
Site 137
S1160
L
S
V
L
S
V
P
S
P
D
T
A
N
Q
E
Site 138
T1163
L
S
V
P
S
P
D
T
A
N
Q
E
P
T
P
Site 139
T1169
D
T
A
N
Q
E
P
T
P
K
S
P
C
G
L
Site 140
S1172
N
Q
E
P
T
P
K
S
P
C
G
L
T
E
Q
Site 141
Y1180
P
C
G
L
T
E
Q
Y
L
H
K
D
R
W
P
Site 142
S1190
K
D
R
W
P
E
V
S
P
E
D
T
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T
T
P
V
I
S
S
V
Site 295
S2276
S
S
V
A
E
R
F
S
P
S
L
E
A
A
E
Site 296
S2278
V
A
E
R
F
S
P
S
L
E
A
A
E
Q
E
Site 297
S2299
G
M
E
P
A
A
H
S
L
W
D
L
T
P
L
Site 298
T2304
A
H
S
L
W
D
L
T
P
L
S
P
A
P
P
Site 299
T2344
L
E
C
S
E
A
A
T
E
K
P
S
P
F
Q
Site 300
S2348
E
A
A
T
E
K
P
S
P
F
Q
V
P
S
E
Site 301
S2354
P
S
P
F
Q
V
P
S
E
D
C
A
A
N
G
Site 302
S2366
A
N
G
P
T
E
T
S
P
N
P
P
G
P
A
Site 303
S2400
W
P
E
G
A
E
R
S
S
R
P
D
T
L
L
Site 304
S2401
P
E
G
A
E
R
S
S
R
P
D
T
L
L
S
Site 305
T2405
E
R
S
S
R
P
D
T
L
L
S
P
E
Q
P
Site 306
S2408
S
R
P
D
T
L
L
S
P
E
Q
P
V
C
P
Site 307
S2419
P
V
C
P
A
G
G
S
G
G
P
P
S
S
A
Site 308
S2424
G
G
S
G
G
P
P
S
S
A
S
P
E
V
E
Site 309
S2425
G
S
G
G
P
P
S
S
A
S
P
E
V
E
A
Site 310
S2427
G
G
P
P
S
S
A
S
P
E
V
E
A
G
P
Site 311
T2439
A
G
P
Q
G
C
A
T
E
P
R
P
H
R
G
Site 312
S2449
R
P
H
R
G
E
L
S
P
S
F
L
N
P
P
Site 313
S2451
H
R
G
E
L
S
P
S
F
L
N
P
P
L
P
Site 314
S2460
L
N
P
P
L
P
P
S
I
D
D
R
D
L
S
Site 315
S2467
S
I
D
D
R
D
L
S
T
E
E
V
R
L
V
Site 316
T2468
I
D
D
R
D
L
S
T
E
E
V
R
L
V
G
Site 317
T2495
T
G
G
P
C
P
V
T
D
E
T
P
P
T
S
Site 318
T2498
P
C
P
V
T
D
E
T
P
P
T
S
A
S
D
Site 319
T2501
V
T
D
E
T
P
P
T
S
A
S
D
S
G
S
Site 320
S2502
T
D
E
T
P
P
T
S
A
S
D
S
G
S
S
Site 321
S2504
E
T
P
P
T
S
A
S
D
S
G
S
S
Q
S
Site 322
S2506
P
P
T
S
A
S
D
S
G
S
S
Q
S
D
S
Site 323
S2508
T
S
A
S
D
S
G
S
S
Q
S
D
S
D
V
Site 324
S2509
S
A
S
D
S
G
S
S
Q
S
D
S
D
V
P
Site 325
S2511
S
D
S
G
S
S
Q
S
D
S
D
V
P
P
E
Site 326
S2513
S
G
S
S
Q
S
D
S
D
V
P
P
E
T
E
Site 327
T2519
D
S
D
V
P
P
E
T
E
E
C
P
S
I
T
Site 328
S2524
P
E
T
E
E
C
P
S
I
T
A
E
A
A
L
Site 329
S2533
T
A
E
A
A
L
D
S
D
E
D
G
D
F
L
Site 330
T2551
K
A
G
G
V
S
G
T
H
H
P
R
P
G
H
Site 331
S2571
P
Q
P
D
P
R
P
S
P
P
R
P
D
V
C
Site 332
S2587
A
D
P
E
G
L
S
S
E
S
G
R
V
E
R
Site 333
S2617
P
G
K
A
K
P
A
S
P
A
R
R
L
D
L
Site 334
S2629
L
D
L
R
G
K
R
S
P
T
P
G
K
G
P
Site 335
T2631
L
R
G
K
R
S
P
T
P
G
K
G
P
A
D
Site 336
S2641
K
G
P
A
D
R
A
S
R
A
P
P
R
P
R
Site 337
S2649
R
A
P
P
R
P
R
S
T
T
S
Q
V
T
P
Site 338
T2650
A
P
P
R
P
R
S
T
T
S
Q
V
T
P
A
Site 339
T2651
P
P
R
P
R
S
T
T
S
Q
V
T
P
A
E
Site 340
S2652
P
R
P
R
S
T
T
S
Q
V
T
P
A
E
E
Site 341
T2655
R
S
T
T
S
Q
V
T
P
A
E
E
K
D
G
Site 342
S2664
A
E
E
K
D
G
H
S
P
M
S
K
G
L
V
Site 343
S2667
K
D
G
H
S
P
M
S
K
G
L
V
N
G
L
Site 344
S2679
N
G
L
K
A
G
P
S
A
L
S
S
K
G
S
Site 345
S2682
K
A
G
P
S
A
L
S
S
K
G
S
S
G
A
Site 346
S2683
A
G
P
S
A
L
S
S
K
G
S
S
G
A
P
Site 347
S2686
S
A
L
S
S
K
G
S
S
G
A
P
V
Y
V
Site 348
S2687
A
L
S
S
K
G
S
S
G
A
P
V
Y
V
D
Site 349
Y2692
G
S
S
G
A
P
V
Y
V
D
L
A
Y
I
P
Site 350
S2718
F
F
R
R
V
R
A
S
Y
Y
V
V
S
G
N
Site 351
Y2719
F
R
R
V
R
A
S
Y
Y
V
V
S
G
N
D
Site 352
Y2720
R
R
V
R
A
S
Y
Y
V
V
S
G
N
D
P
Site 353
T2756
E
N
L
Q
V
S
V
T
L
I
P
T
H
D
T
Site 354
T2763
T
L
I
P
T
H
D
T
E
V
T
R
E
W
Y
Site 355
T2766
P
T
H
D
T
E
V
T
R
E
W
Y
Q
Q
T
Site 356
Y2770
T
E
V
T
R
E
W
Y
Q
Q
T
H
E
Q
Q
Site 357
S2797
T
V
V
M
Q
D
E
S
F
P
A
C
K
I
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation