PhosphoNET

           
Protein Info 
   
Short Name:  PHEX
Full Name:  Phosphate-regulating neutral endopeptidase
Alias:  HPDR; HPDR1; HYP; HYP1; Metalloendopeptidase PEX; PEX; Phosphate regulating endopeptidase, X-linked; Vitamin D-resistant hypophosphatemic rickets protein; XLH; X-linked hypophosphatemia protein
Type:  Membrane protein, integral; EC 3.4.24.-; Protease
Mass (Da):  86470
Number AA: 
UniProt ID:  P78562
International Prot ID: 
Sequence:  Retrieve full protein sequence
   
GO Terms  External Links Internal Links  
   
Cellular Component:  GO:0005887     Uniprot OncoNet
Molecular Function:  GO:0004177  GO:0004222  GO:0008270 PhosphoSite+ KinaseNET
Biological Process:  GO:0031214  GO:0007267  GO:0006464 Phosida TranscriptoNet
    STRING Kinexus Products
   
Info Box  A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites 
-7-6-5-4-3-2-101234567Expt. conf.EffectKinasePPaseKinexus ProductsRef.Evol.Kinase Pred.P-site Match
Site 1T5___MEAETGSSVETG
Site 2S7_MEAETGSSVETGKK
Site 3S8MEAETGSSVETGKKA
Site 4T11ETGSSVETGKKANRG
Site 5T129SISRRRDTEAIQKAK
Site 6S140QKAKILYSSCMNEKA
Site 7S141KAKILYSSCMNEKAI
Site 8S186VWSERKFSLLQTLAT
Site 9T190RKFSLLQTLATFRGQ
Site 10T193SLLQTLATFRGQYSN
Site 11Y346VVVRVPQYFKDLFRI
Site 12Y657LREAFRAYRKWINDR
Site 13Y688NQLFFLSYAHVRCNS
Site 14S695YAHVRCNSYRPEAAR
Site 15S711QVQIGAHSPPQFRVN
 
Legend 
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available  
Products available
 


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