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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
GPLD1
Full Name:
Phosphatidylinositol-glycan-specific phospholipase D
Alias:
EC 3.1.4.50; Glycosyl-phosphatidylinositol-specific phospholipase D; GPIPLD; PHL1; PHLD; PI-G PLD; PIGPLD1
Type:
Phospholipase
Mass (Da):
92336
Number AA:
840
UniProt ID:
P80108
International Prot ID:
IPI00299503
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0004621
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S22
G
S
L
C
H
R
G
S
P
C
G
L
S
T
H
Site 2
S27
R
G
S
P
C
G
L
S
T
H
V
E
I
G
H
Site 3
T28
G
S
P
C
G
L
S
T
H
V
E
I
G
H
R
Site 4
Y49
L
H
N
G
R
V
N
Y
R
E
L
L
L
E
H
Site 5
S84
G
G
K
F
H
D
V
S
E
S
T
H
W
T
P
Site 6
T90
V
S
E
S
T
H
W
T
P
F
L
N
A
S
V
Site 7
Y104
V
H
Y
I
R
E
N
Y
P
L
P
W
E
K
D
Site 8
S131
S
H
M
A
A
D
V
S
W
H
S
L
G
L
E
Site 9
S153
G
A
I
D
F
H
G
S
Y
S
E
A
H
S
A
Site 10
S155
I
D
F
H
G
S
Y
S
E
A
H
S
A
G
D
Site 11
S159
G
S
Y
S
E
A
H
S
A
G
D
F
G
G
D
Site 12
S169
D
F
G
G
D
V
L
S
Q
F
E
F
N
F
N
Site 13
Y177
Q
F
E
F
N
F
N
Y
L
A
R
R
W
Y
V
Site 14
Y183
N
Y
L
A
R
R
W
Y
V
P
V
K
D
L
L
Site 15
Y193
V
K
D
L
L
G
I
Y
E
K
L
Y
G
R
K
Site 16
Y197
L
G
I
Y
E
K
L
Y
G
R
K
V
I
T
E
Site 17
Y229
M
L
A
V
S
K
L
Y
P
T
Y
S
T
K
S
Site 18
T231
A
V
S
K
L
Y
P
T
Y
S
T
K
S
P
F
Site 19
Y232
V
S
K
L
Y
P
T
Y
S
T
K
S
P
F
L
Site 20
S233
S
K
L
Y
P
T
Y
S
T
K
S
P
F
L
V
Site 21
T234
K
L
Y
P
T
Y
S
T
K
S
P
F
L
V
E
Site 22
S236
Y
P
T
Y
S
T
K
S
P
F
L
V
E
Q
F
Site 23
Y246
L
V
E
Q
F
Q
E
Y
F
L
G
G
L
D
D
Site 24
S274
F
M
L
E
N
G
T
S
D
C
N
L
P
E
N
Site 25
T294
C
G
G
Q
Q
N
H
T
Q
G
S
K
M
Q
K
Site 26
T309
N
D
F
H
R
N
L
T
T
S
L
T
E
S
V
Site 27
S311
F
H
R
N
L
T
T
S
L
T
E
S
V
D
R
Site 28
T313
R
N
L
T
T
S
L
T
E
S
V
D
R
N
I
Site 29
S315
L
T
T
S
L
T
E
S
V
D
R
N
I
N
Y
Site 30
Y322
S
V
D
R
N
I
N
Y
T
E
R
G
V
F
F
Site 31
T323
V
D
R
N
I
N
Y
T
E
R
G
V
F
F
S
Site 32
S330
T
E
R
G
V
F
F
S
V
N
S
W
T
P
D
Site 33
S333
G
V
F
F
S
V
N
S
W
T
P
D
S
M
S
Site 34
S340
S
W
T
P
D
S
M
S
F
I
Y
K
A
L
E
Site 35
S358
R
T
M
F
I
G
G
S
Q
L
S
Q
K
H
V
Site 36
S361
F
I
G
G
S
Q
L
S
Q
K
H
V
S
S
P
Site 37
S367
L
S
Q
K
H
V
S
S
P
L
A
S
Y
F
L
Site 38
Y405
L
V
V
G
A
P
G
Y
S
R
P
G
H
I
H
Site 39
T480
S
V
G
S
E
Q
L
T
Y
K
G
A
V
Y
V
Site 40
Y481
V
G
S
E
Q
L
T
Y
K
G
A
V
Y
V
Y
Site 41
Y486
L
T
Y
K
G
A
V
Y
V
Y
F
G
S
K
Q
Site 42
Y488
Y
K
G
A
V
Y
V
Y
F
G
S
K
Q
G
G
Site 43
S491
A
V
Y
V
Y
F
G
S
K
Q
G
G
M
S
S
Site 44
S497
G
S
K
Q
G
G
M
S
S
S
P
N
I
T
I
Site 45
S498
S
K
Q
G
G
M
S
S
S
P
N
I
T
I
S
Site 46
S499
K
Q
G
G
M
S
S
S
P
N
I
T
I
S
C
Site 47
T503
M
S
S
S
P
N
I
T
I
S
C
Q
D
I
Y
Site 48
S526
A
A
D
V
N
G
D
S
E
P
D
L
V
I
G
Site 49
S555
A
A
F
Y
S
G
P
S
L
S
D
K
E
K
L
Site 50
S557
F
Y
S
G
P
S
L
S
D
K
E
K
L
N
V
Site 51
T570
N
V
E
A
A
N
W
T
V
R
G
E
E
D
F
Site 52
T588
G
Y
S
L
H
G
V
T
V
D
N
R
T
L
L
Site 53
S599
R
T
L
L
L
V
G
S
P
T
W
K
N
A
S
Site 54
S620
H
I
R
D
E
K
K
S
L
G
R
V
Y
G
Y
Site 55
Y625
K
K
S
L
G
R
V
Y
G
Y
F
P
P
N
G
Site 56
Y627
S
L
G
R
V
Y
G
Y
F
P
P
N
G
Q
S
Site 57
S639
G
Q
S
W
F
T
I
S
G
D
K
A
M
G
K
Site 58
T649
K
A
M
G
K
L
G
T
S
L
S
S
G
H
V
Site 59
S652
G
K
L
G
T
S
L
S
S
G
H
V
L
M
N
Site 60
Y695
Q
G
G
A
T
R
M
Y
A
L
T
S
D
A
Q
Site 61
S707
D
A
Q
P
L
L
L
S
T
F
S
G
D
R
R
Site 62
T708
A
Q
P
L
L
L
S
T
F
S
G
D
R
R
F
Site 63
S710
P
L
L
L
S
T
F
S
G
D
R
R
F
S
R
Site 64
S716
F
S
G
D
R
R
F
S
R
F
G
G
V
L
H
Site 65
Y759
G
G
E
D
G
R
V
Y
V
Y
N
G
K
E
T
Site 66
Y761
E
D
G
R
V
Y
V
Y
N
G
K
E
T
T
L
Site 67
T772
E
T
T
L
G
D
M
T
G
K
C
K
S
W
I
Site 68
T780
G
K
C
K
S
W
I
T
P
C
P
E
E
K
A
Site 69
Y789
C
P
E
E
K
A
Q
Y
V
L
I
S
P
E
A
Site 70
S793
K
A
Q
Y
V
L
I
S
P
E
A
S
S
R
F
Site 71
S802
E
A
S
S
R
F
G
S
S
L
I
T
V
R
S
Site 72
S803
A
S
S
R
F
G
S
S
L
I
T
V
R
S
K
Site 73
T806
R
F
G
S
S
L
I
T
V
R
S
K
A
K
N
Site 74
S809
S
S
L
I
T
V
R
S
K
A
K
N
Q
V
V
Site 75
S836
S
G
A
L
H
V
Y
S
L
G
S
D
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation