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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SIM1
Full Name:
Single-minded homolog 1
Alias:
BHLHe14; Single-minded 1
Type:
Transcription factor
Mass (Da):
85496
Number AA:
766
UniProt ID:
P81133
International Prot ID:
IPI00292234
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005794
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0004871
GO:0003700
PhosphoSite+
KinaseNET
Biological Process:
GO:0030154
GO:0007399
GO:0006355
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S18
T
R
R
E
K
E
N
S
E
F
Y
E
L
A
K
Site 2
S41
T
S
Q
L
D
K
A
S
I
I
R
L
T
T
S
Site 3
T46
K
A
S
I
I
R
L
T
T
S
Y
L
K
M
R
Site 4
S67
L
G
E
A
W
G
H
S
S
R
T
S
P
L
D
Site 5
S68
G
E
A
W
G
H
S
S
R
T
S
P
L
D
N
Site 6
S71
W
G
H
S
S
R
T
S
P
L
D
N
V
G
R
Site 7
Y125
E
L
T
G
N
S
I
Y
E
Y
I
H
P
A
D
Site 8
Y127
T
G
N
S
I
Y
E
Y
I
H
P
A
D
H
D
Site 9
T137
P
A
D
H
D
E
M
T
A
V
L
T
A
H
Q
Site 10
Y154
H
S
H
F
V
Q
E
Y
E
I
E
R
S
F
F
Site 11
T176
A
K
R
N
A
G
L
T
C
G
G
Y
K
V
I
Site 12
Y188
K
V
I
H
C
S
G
Y
L
K
I
R
Q
Y
S
Site 13
Y194
G
Y
L
K
I
R
Q
Y
S
L
D
M
S
P
F
Site 14
S195
Y
L
K
I
R
Q
Y
S
L
D
M
S
P
F
D
Site 15
S199
R
Q
Y
S
L
D
M
S
P
F
D
G
C
Y
Q
Site 16
T253
D
S
R
V
A
E
L
T
G
Y
E
P
Q
D
L
Site 17
Y255
R
V
A
E
L
T
G
Y
E
P
Q
D
L
I
E
Site 18
Y266
D
L
I
E
K
T
L
Y
H
H
V
H
G
C
D
Site 19
Y294
K
G
Q
V
T
T
K
Y
Y
R
F
L
A
K
H
Site 20
S317
Y
A
T
I
V
H
N
S
R
S
S
R
P
H
C
Site 21
S319
T
I
V
H
N
S
R
S
S
R
P
H
C
I
V
Site 22
S320
I
V
H
N
S
R
S
S
R
P
H
C
I
V
S
Site 23
T335
V
N
Y
V
L
T
D
T
E
Y
K
G
L
Q
L
Site 24
Y337
Y
V
L
T
D
T
E
Y
K
G
L
Q
L
S
L
Site 25
S343
E
Y
K
G
L
Q
L
S
L
D
Q
I
S
A
S
Site 26
S348
Q
L
S
L
D
Q
I
S
A
S
K
P
A
F
S
Site 27
S350
S
L
D
Q
I
S
A
S
K
P
A
F
S
Y
T
Site 28
S355
S
A
S
K
P
A
F
S
Y
T
S
S
S
T
P
Site 29
Y356
A
S
K
P
A
F
S
Y
T
S
S
S
T
P
T
Site 30
T357
S
K
P
A
F
S
Y
T
S
S
S
T
P
T
M
Site 31
S358
K
P
A
F
S
Y
T
S
S
S
T
P
T
M
T
Site 32
S359
P
A
F
S
Y
T
S
S
S
T
P
T
M
T
D
Site 33
S360
A
F
S
Y
T
S
S
S
T
P
T
M
T
D
N
Site 34
T361
F
S
Y
T
S
S
S
T
P
T
M
T
D
N
R
Site 35
T363
Y
T
S
S
S
T
P
T
M
T
D
N
R
K
G
Site 36
T365
S
S
S
T
P
T
M
T
D
N
R
K
G
A
K
Site 37
S373
D
N
R
K
G
A
K
S
R
L
S
S
S
K
S
Site 38
S376
K
G
A
K
S
R
L
S
S
S
K
S
K
S
R
Site 39
S377
G
A
K
S
R
L
S
S
S
K
S
K
S
R
T
Site 40
S378
A
K
S
R
L
S
S
S
K
S
K
S
R
T
S
Site 41
S380
S
R
L
S
S
S
K
S
K
S
R
T
S
P
Y
Site 42
S382
L
S
S
S
K
S
K
S
R
T
S
P
Y
P
Q
Site 43
T384
S
S
K
S
K
S
R
T
S
P
Y
P
Q
Y
S
Site 44
S385
S
K
S
K
S
R
T
S
P
Y
P
Q
Y
S
G
Site 45
Y387
S
K
S
R
T
S
P
Y
P
Q
Y
S
G
F
H
Site 46
Y390
R
T
S
P
Y
P
Q
Y
S
G
F
H
T
E
R
Site 47
S391
T
S
P
Y
P
Q
Y
S
G
F
H
T
E
R
S
Site 48
T395
P
Q
Y
S
G
F
H
T
E
R
S
E
S
D
H
Site 49
S398
S
G
F
H
T
E
R
S
E
S
D
H
D
S
Q
Site 50
S400
F
H
T
E
R
S
E
S
D
H
D
S
Q
W
G
Site 51
S404
R
S
E
S
D
H
D
S
Q
W
G
G
S
P
L
Site 52
S409
H
D
S
Q
W
G
G
S
P
L
T
D
T
A
S
Site 53
T412
Q
W
G
G
S
P
L
T
D
T
A
S
P
Q
L
Site 54
T414
G
G
S
P
L
T
D
T
A
S
P
Q
L
L
D
Site 55
S416
S
P
L
T
D
T
A
S
P
Q
L
L
D
P
A
Site 56
S428
D
P
A
D
R
P
G
S
Q
H
D
A
S
C
A
Site 57
S433
P
G
S
Q
H
D
A
S
C
A
Y
R
Q
F
S
Site 58
S440
S
C
A
Y
R
Q
F
S
D
R
S
S
L
C
Y
Site 59
S444
R
Q
F
S
D
R
S
S
L
C
Y
G
F
A
L
Site 60
Y447
S
D
R
S
S
L
C
Y
G
F
A
L
D
H
S
Site 61
S454
Y
G
F
A
L
D
H
S
R
L
V
E
E
R
H
Site 62
Y477
G
R
C
E
A
G
R
Y
F
L
G
T
P
Q
A
Site 63
T481
A
G
R
Y
F
L
G
T
P
Q
A
G
R
E
P
Site 64
T499
S
R
A
A
L
P
L
T
K
A
S
P
E
S
R
Site 65
S502
A
L
P
L
T
K
A
S
P
E
S
R
E
A
Y
Site 66
Y509
S
P
E
S
R
E
A
Y
E
N
S
M
P
H
I
Site 67
S512
S
R
E
A
Y
E
N
S
M
P
H
I
A
S
V
Site 68
S532
R
G
H
W
D
E
D
S
V
V
S
S
P
D
P
Site 69
S536
D
E
D
S
V
V
S
S
P
D
P
G
S
A
S
Site 70
S541
V
S
S
P
D
P
G
S
A
S
E
S
G
D
R
Site 71
S543
S
P
D
P
G
S
A
S
E
S
G
D
R
Y
R
Site 72
S545
D
P
G
S
A
S
E
S
G
D
R
Y
R
T
E
Site 73
Y549
A
S
E
S
G
D
R
Y
R
T
E
Q
Y
Q
S
Site 74
T551
E
S
G
D
R
Y
R
T
E
Q
Y
Q
S
S
P
Site 75
S556
Y
R
T
E
Q
Y
Q
S
S
P
H
E
P
S
K
Site 76
S557
R
T
E
Q
Y
Q
S
S
P
H
E
P
S
K
I
Site 77
S562
Q
S
S
P
H
E
P
S
K
I
E
T
L
I
R
Site 78
T566
H
E
P
S
K
I
E
T
L
I
R
A
T
Q
Q
Site 79
T571
I
E
T
L
I
R
A
T
Q
Q
M
I
K
E
E
Site 80
S589
L
Q
L
R
K
A
P
S
D
Q
L
A
S
I
N
Site 81
Y609
H
S
L
C
F
A
N
Y
Q
Q
P
P
P
T
G
Site 82
T615
N
Y
Q
Q
P
P
P
T
G
E
V
C
H
G
S
Site 83
S628
G
S
A
L
A
N
T
S
P
C
D
H
I
Q
Q
Site 84
S642
Q
R
E
G
K
M
L
S
P
H
E
N
D
Y
D
Site 85
Y648
L
S
P
H
E
N
D
Y
D
N
S
P
T
A
L
Site 86
S651
H
E
N
D
Y
D
N
S
P
T
A
L
S
R
I
Site 87
S656
D
N
S
P
T
A
L
S
R
I
S
S
P
N
S
Site 88
S659
P
T
A
L
S
R
I
S
S
P
N
S
D
R
I
Site 89
S660
T
A
L
S
R
I
S
S
P
N
S
D
R
I
S
Site 90
S663
S
R
I
S
S
P
N
S
D
R
I
S
K
S
S
Site 91
S667
S
P
N
S
D
R
I
S
K
S
S
L
I
L
A
Site 92
S669
N
S
D
R
I
S
K
S
S
L
I
L
A
K
D
Site 93
S670
S
D
R
I
S
K
S
S
L
I
L
A
K
D
Y
Site 94
Y677
S
L
I
L
A
K
D
Y
L
H
S
D
I
S
P
Site 95
S680
L
A
K
D
Y
L
H
S
D
I
S
P
H
Q
T
Site 96
S683
D
Y
L
H
S
D
I
S
P
H
Q
T
A
G
D
Site 97
T687
S
D
I
S
P
H
Q
T
A
G
D
H
P
T
V
Site 98
T693
Q
T
A
G
D
H
P
T
V
S
P
N
C
F
G
Site 99
S695
A
G
D
H
P
T
V
S
P
N
C
F
G
S
H
Site 100
Y705
C
F
G
S
H
R
Q
Y
F
D
K
H
A
Y
T
Site 101
T714
D
K
H
A
Y
T
L
T
G
Y
A
L
E
H
L
Site 102
Y722
G
Y
A
L
E
H
L
Y
D
S
E
T
I
R
N
Site 103
S724
A
L
E
H
L
Y
D
S
E
T
I
R
N
Y
S
Site 104
T726
E
H
L
Y
D
S
E
T
I
R
N
Y
S
L
G
Site 105
Y730
D
S
E
T
I
R
N
Y
S
L
G
C
N
G
S
Site 106
S731
S
E
T
I
R
N
Y
S
L
G
C
N
G
S
H
Site 107
S737
Y
S
L
G
C
N
G
S
H
F
D
V
T
S
H
Site 108
T742
N
G
S
H
F
D
V
T
S
H
L
R
M
Q
P
Site 109
S743
G
S
H
F
D
V
T
S
H
L
R
M
Q
P
D
Site 110
S759
A
Q
G
H
K
G
T
S
V
I
I
T
N
G
S
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation