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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ADAMTSL3
Full Name:
ADAMTS-like protein 3
Alias:
a disintegrin-like and metalloprotease domain with thrombospondin type I motifs-like 3; ADAMTS-like 3; ATL3; KIAA1233; punctin-2
Type:
Mass (Da):
188640
Number AA:
UniProt ID:
P82987
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005578
Uniprot
OncoNet
Molecular Function:
GO:0008237
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T24
M
H
S
P
L
P
Q
T
T
A
E
K
S
P
G
Site 2
T25
H
S
P
L
P
Q
T
T
A
E
K
S
P
G
A
Site 3
S29
P
Q
T
T
A
E
K
S
P
G
A
Y
F
L
P
Site 4
S45
F
A
L
S
P
Q
G
S
F
L
E
D
T
T
G
Site 5
T50
Q
G
S
F
L
E
D
T
T
G
E
Q
F
L
T
Site 6
T51
G
S
F
L
E
D
T
T
G
E
Q
F
L
T
Y
Site 7
T57
T
T
G
E
Q
F
L
T
Y
R
Y
D
D
Q
T
Site 8
Y58
T
G
E
Q
F
L
T
Y
R
Y
D
D
Q
T
S
Site 9
Y60
E
Q
F
L
T
Y
R
Y
D
D
Q
T
S
R
N
Site 10
T64
T
Y
R
Y
D
D
Q
T
S
R
N
T
R
S
D
Site 11
T68
D
D
Q
T
S
R
N
T
R
S
D
E
D
K
D
Site 12
S70
Q
T
S
R
N
T
R
S
D
E
D
K
D
G
N
Site 13
S96
R
T
C
G
G
G
A
S
Y
S
L
R
R
C
L
Site 14
S98
C
G
G
G
A
S
Y
S
L
R
R
C
L
T
G
Site 15
T104
Y
S
L
R
R
C
L
T
G
R
N
C
E
G
Q
Site 16
Y115
C
E
G
Q
N
I
R
Y
K
T
C
S
N
H
D
Site 17
Y138
R
A
Q
Q
C
S
A
Y
N
D
V
Q
Y
Q
G
Site 18
Y143
S
A
Y
N
D
V
Q
Y
Q
G
H
Y
Y
E
W
Site 19
Y147
D
V
Q
Y
Q
G
H
Y
Y
E
W
L
P
R
Y
Site 20
Y148
V
Q
Y
Q
G
H
Y
Y
E
W
L
P
R
Y
N
Site 21
Y154
Y
Y
E
W
L
P
R
Y
N
D
P
A
A
P
C
Site 22
T184
A
P
K
V
L
D
G
T
R
C
N
T
D
S
L
Site 23
T188
L
D
G
T
R
C
N
T
D
S
L
D
M
C
I
Site 24
S190
G
T
R
C
N
T
D
S
L
D
M
C
I
S
G
Site 25
T226
V
C
A
G
D
G
S
T
C
R
L
V
R
G
Q
Site 26
S234
C
R
L
V
R
G
Q
S
K
S
H
V
S
P
E
Site 27
S236
L
V
R
G
Q
S
K
S
H
V
S
P
E
K
R
Site 28
S239
G
Q
S
K
S
H
V
S
P
E
K
R
E
E
N
Site 29
T260
G
S
R
S
V
R
I
T
V
K
G
P
A
H
L
Site 30
T273
H
L
V
I
E
S
K
T
L
Q
G
S
K
G
E
Site 31
S282
Q
G
S
K
G
E
H
S
F
N
S
P
G
V
F
Site 32
S285
K
G
E
H
S
F
N
S
P
G
V
F
L
V
E
Site 33
T295
V
F
L
V
E
N
T
T
V
E
F
Q
R
G
S
Site 34
S302
T
V
E
F
Q
R
G
S
E
R
Q
T
F
K
I
Site 35
T306
Q
R
G
S
E
R
Q
T
F
K
I
P
G
P
L
Site 36
Y323
D
F
I
F
K
T
R
Y
T
A
A
K
D
S
V
Site 37
Y379
K
R
V
V
P
D
H
Y
C
H
Y
Y
P
E
N
Site 38
Y382
V
P
D
H
Y
C
H
Y
Y
P
E
N
V
K
P
Site 39
Y383
P
D
H
Y
C
H
Y
Y
P
E
N
V
K
P
K
Site 40
S397
K
P
K
L
K
E
C
S
M
D
P
C
P
S
S
Site 41
S404
S
M
D
P
C
P
S
S
D
G
F
K
E
I
M
Site 42
Y413
G
F
K
E
I
M
P
Y
D
H
F
Q
P
L
P
Site 43
S442
G
G
G
I
Q
R
R
S
F
V
C
V
E
E
S
Site 44
Y535
C
V
I
P
I
P
C
Y
K
P
K
E
K
S
P
Site 45
S541
C
Y
K
P
K
E
K
S
P
V
E
A
K
L
P
Site 46
T563
L
E
E
T
R
I
A
T
E
E
P
T
F
I
P
Site 47
T567
R
I
A
T
E
E
P
T
F
I
P
E
P
W
S
Site 48
S577
P
E
P
W
S
A
C
S
T
T
C
G
P
G
V
Site 49
T578
E
P
W
S
A
C
S
T
T
C
G
P
G
V
Q
Site 50
T596
V
K
C
R
V
L
L
T
F
T
Q
T
E
T
E
Site 51
T602
L
T
F
T
Q
T
E
T
E
L
P
E
E
E
C
Site 52
T616
C
E
G
P
K
L
P
T
E
R
P
C
L
L
E
Site 53
S628
L
L
E
A
C
D
E
S
P
A
S
R
E
L
D
Site 54
S631
A
C
D
E
S
P
A
S
R
E
L
D
I
P
L
Site 55
S642
D
I
P
L
P
E
D
S
E
T
T
Y
D
W
E
Site 56
T644
P
L
P
E
D
S
E
T
T
Y
D
W
E
Y
A
Site 57
Y646
P
E
D
S
E
T
T
Y
D
W
E
Y
A
G
F
Site 58
Y650
E
T
T
Y
D
W
E
Y
A
G
F
T
P
C
T
Site 59
T679
L
H
I
Q
T
Q
Q
T
V
N
D
S
L
C
D
Site 60
S695
V
H
R
P
P
A
M
S
Q
A
C
N
T
E
P
Site 61
Y729
G
I
Q
T
R
D
V
Y
C
L
H
P
G
E
T
Site 62
T736
Y
C
L
H
P
G
E
T
P
A
P
P
E
E
C
Site 63
T785
G
T
Q
N
R
R
V
T
C
R
Q
L
L
T
D
Site 64
S794
R
Q
L
L
T
D
G
S
F
L
N
L
S
D
E
Site 65
S799
D
G
S
F
L
N
L
S
D
E
L
C
Q
G
P
Site 66
S809
L
C
Q
G
P
K
A
S
S
H
K
S
C
A
R
Site 67
S813
P
K
A
S
S
H
K
S
C
A
R
T
D
C
P
Site 68
T817
S
H
K
S
C
A
R
T
D
C
P
P
H
L
A
Site 69
S859
K
G
R
R
I
P
L
S
E
M
M
C
R
D
L
Site 70
S874
P
G
L
P
L
V
R
S
C
Q
M
P
E
C
S
Site 71
S885
P
E
C
S
K
I
K
S
E
M
K
T
K
L
G
Site 72
T889
K
I
K
S
E
M
K
T
K
L
G
E
Q
G
P
Site 73
S900
E
Q
G
P
Q
I
L
S
V
Q
R
V
Y
I
Q
Site 74
Y905
I
L
S
V
Q
R
V
Y
I
Q
T
R
E
E
K
Site 75
T908
V
Q
R
V
Y
I
Q
T
R
E
E
K
R
I
N
Site 76
S942
P
V
R
R
F
Q
K
S
L
I
Q
W
E
K
D
Site 77
S956
D
G
R
C
L
Q
N
S
K
R
L
G
I
T
K
Site 78
T962
N
S
K
R
L
G
I
T
K
S
G
S
L
K
I
Site 79
S964
K
R
L
G
I
T
K
S
G
S
L
K
I
H
G
Site 80
Y1015
L
R
E
P
M
R
E
Y
P
G
M
D
H
S
E
Site 81
S1021
E
Y
P
G
M
D
H
S
E
A
N
S
L
G
V
Site 82
S1025
M
D
H
S
E
A
N
S
L
G
V
T
W
H
K
Site 83
Y1044
W
N
N
K
N
D
L
Y
L
D
D
D
H
I
S
Site 84
S1051
Y
L
D
D
D
H
I
S
N
Q
P
F
L
R
A
Site 85
S1064
R
A
L
L
G
H
C
S
N
S
A
G
S
T
N
Site 86
S1066
L
L
G
H
C
S
N
S
A
G
S
T
N
S
W
Site 87
T1070
C
S
N
S
A
G
S
T
N
S
W
E
L
K
N
Site 88
T1093
Q
G
A
Y
S
M
D
T
A
Q
F
D
E
L
I
Site 89
S1104
D
E
L
I
R
N
M
S
Q
L
M
E
T
G
E
Site 90
S1113
L
M
E
T
G
E
V
S
D
D
L
A
S
Q
L
Site 91
T1145
W
R
G
I
Q
E
E
T
P
P
A
A
Q
L
R
Site 92
T1155
A
A
Q
L
R
G
E
T
G
S
V
S
Q
S
S
Site 93
S1157
Q
L
R
G
E
T
G
S
V
S
Q
S
S
H
A
Site 94
S1159
R
G
E
T
G
S
V
S
Q
S
S
H
A
K
N
Site 95
S1161
E
T
G
S
V
S
Q
S
S
H
A
K
N
S
G
Site 96
S1162
T
G
S
V
S
Q
S
S
H
A
K
N
S
G
K
Site 97
T1171
A
K
N
S
G
K
L
T
F
K
P
K
G
P
V
Site 98
S1183
G
P
V
L
M
R
Q
S
Q
P
P
S
I
S
F
Site 99
S1187
M
R
Q
S
Q
P
P
S
I
S
F
N
K
T
I
Site 100
S1189
Q
S
Q
P
P
S
I
S
F
N
K
T
I
N
S
Site 101
T1193
P
S
I
S
F
N
K
T
I
N
S
R
I
G
N
Site 102
S1196
S
F
N
K
T
I
N
S
R
I
G
N
T
V
Y
Site 103
Y1203
S
R
I
G
N
T
V
Y
I
T
K
R
T
E
V
Site 104
T1205
I
G
N
T
V
Y
I
T
K
R
T
E
V
I
N
Site 105
Y1225
I
T
P
S
E
A
T
Y
T
W
T
K
D
G
T
Site 106
T1226
T
P
S
E
A
T
Y
T
W
T
K
D
G
T
L
Site 107
T1232
Y
T
W
T
K
D
G
T
L
L
Q
P
S
V
K
Site 108
Y1261
T
R
K
E
Q
G
I
Y
E
C
S
V
A
N
H
Site 109
S1264
E
Q
G
I
Y
E
C
S
V
A
N
H
L
G
S
Site 110
S1271
S
V
A
N
H
L
G
S
D
V
E
S
S
S
V
Site 111
S1275
H
L
G
S
D
V
E
S
S
S
V
L
Y
A
E
Site 112
S1277
G
S
D
V
E
S
S
S
V
L
Y
A
E
A
P
Site 113
T1294
L
S
V
E
R
N
I
T
K
P
E
H
N
H
L
Site 114
S1339
T
W
L
K
R
G
G
S
L
S
G
N
V
S
L
Site 115
S1358
S
L
L
L
Q
N
V
S
L
E
N
E
G
T
Y
Site 116
Y1365
S
L
E
N
E
G
T
Y
V
C
I
A
T
N
A
Site 117
S1392
L
E
R
R
W
P
E
S
R
I
V
F
L
Q
G
Site 118
Y1403
F
L
Q
G
H
K
K
Y
I
L
Q
A
T
N
T
Site 119
T1408
K
K
Y
I
L
Q
A
T
N
T
R
T
N
S
N
Site 120
T1410
Y
I
L
Q
A
T
N
T
R
T
N
S
N
D
P
Site 121
S1414
A
T
N
T
R
T
N
S
N
D
P
T
G
E
P
Site 122
T1418
R
T
N
S
N
D
P
T
G
E
P
P
P
Q
E
Site 123
S1496
T
S
V
W
S
Q
C
S
V
S
C
G
E
G
Y
Site 124
Y1503
S
V
S
C
G
E
G
Y
H
S
R
Q
V
T
C
Site 125
S1505
S
C
G
E
G
Y
H
S
R
Q
V
T
C
K
R
Site 126
T1509
G
Y
H
S
R
Q
V
T
C
K
R
T
K
A
N
Site 127
T1518
K
R
T
K
A
N
G
T
V
Q
V
V
S
P
R
Site 128
S1523
N
G
T
V
Q
V
V
S
P
R
A
C
A
P
K
Site 129
T1569
V
R
M
Q
Q
R
H
T
A
C
Q
H
N
S
S
Site 130
S1576
T
A
C
Q
H
N
S
S
D
S
N
C
D
D
R
Site 131
T1587
C
D
D
R
K
R
P
T
L
R
R
N
C
T
S
Site 132
T1593
P
T
L
R
R
N
C
T
S
G
A
C
D
V
C
Site 133
S1676
V
K
H
L
N
L
C
S
L
D
R
Y
K
Q
R
Site 134
Y1680
N
L
C
S
L
D
R
Y
K
Q
R
C
C
Q
S
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation