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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SMAD3
Full Name:
Mothers against decapentaplegic homolog 3
Alias:
SMAD 3
Type:
Nuclear receptor co-regulator; Transcription, coactivator/corepressor
Mass (Da):
48081
Number AA:
425
UniProt ID:
P84022
International Prot ID:
IPI00024305
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
GO:0005637
GO:0043235
Uniprot
OncoNet
Molecular Function:
GO:0070412
GO:0070410
GO:0010843
PhosphoSite+
KinaseNET
Biological Process:
GO:0007183
GO:0006919
GO:0007050
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T8
M
S
S
I
L
P
F
T
P
P
I
V
K
R
L
Site 2
S37
W
C
E
K
A
V
K
S
L
V
K
K
L
K
K
Site 3
T56
D
E
L
E
K
A
I
T
T
Q
N
V
N
T
K
Site 4
T66
N
V
N
T
K
C
I
T
I
P
R
S
L
D
G
Site 5
S70
K
C
I
T
I
P
R
S
L
D
G
R
L
Q
V
Site 6
S78
L
D
G
R
L
Q
V
S
H
R
K
G
L
P
H
Site 7
Y88
K
G
L
P
H
V
I
Y
C
R
L
W
R
W
P
Site 8
Y125
D
E
V
C
V
N
P
Y
H
Y
Q
R
V
E
T
Site 9
Y127
V
C
V
N
P
Y
H
Y
Q
R
V
E
T
P
V
Site 10
T132
Y
H
Y
Q
R
V
E
T
P
V
L
P
P
V
L
Site 11
T144
P
V
L
V
P
R
H
T
E
I
P
A
E
F
P
Site 12
Y156
E
F
P
P
L
D
D
Y
S
H
S
I
P
E
N
Site 13
S157
F
P
P
L
D
D
Y
S
H
S
I
P
E
N
T
Site 14
S159
P
L
D
D
Y
S
H
S
I
P
E
N
T
N
F
Site 15
S174
P
A
G
I
E
P
Q
S
N
I
P
E
T
P
P
Site 16
T179
P
Q
S
N
I
P
E
T
P
P
P
G
Y
L
S
Site 17
Y184
P
E
T
P
P
P
G
Y
L
S
E
D
G
E
T
Site 18
S186
T
P
P
P
G
Y
L
S
E
D
G
E
T
S
D
Site 19
T191
Y
L
S
E
D
G
E
T
S
D
H
Q
M
N
H
Site 20
S192
L
S
E
D
G
E
T
S
D
H
Q
M
N
H
S
Site 21
S199
S
D
H
Q
M
N
H
S
M
D
A
G
S
P
N
Site 22
S204
N
H
S
M
D
A
G
S
P
N
L
S
P
N
P
Site 23
S208
D
A
G
S
P
N
L
S
P
N
P
M
S
P
A
Site 24
S213
N
L
S
P
N
P
M
S
P
A
H
N
N
L
D
Site 25
Y238
F
W
C
S
I
S
Y
Y
E
L
N
Q
R
V
G
Site 26
T247
L
N
Q
R
V
G
E
T
F
H
A
S
Q
P
S
Site 27
S251
V
G
E
T
F
H
A
S
Q
P
S
M
T
V
D
Site 28
T256
H
A
S
Q
P
S
M
T
V
D
G
F
T
D
P
Site 29
T261
S
M
T
V
D
G
F
T
D
P
S
N
S
E
R
Site 30
S264
V
D
G
F
T
D
P
S
N
S
E
R
F
C
L
Site 31
S266
G
F
T
D
P
S
N
S
E
R
F
C
L
G
L
Site 32
T286
R
N
A
A
V
E
L
T
R
R
H
I
G
R
G
Site 33
S309
E
V
F
A
E
C
L
S
D
S
A
I
F
V
Q
Site 34
T330
R
Y
G
W
H
P
A
T
V
C
K
I
P
P
G
Site 35
Y364
N
Q
G
F
E
A
V
Y
Q
L
T
R
M
C
T
Site 36
Y384
V
K
G
W
G
A
E
Y
R
R
Q
T
V
T
S
Site 37
T388
G
A
E
Y
R
R
Q
T
V
T
S
T
P
C
W
Site 38
T390
E
Y
R
R
Q
T
V
T
S
T
P
C
W
I
E
Site 39
S391
Y
R
R
Q
T
V
T
S
T
P
C
W
I
E
L
Site 40
T392
R
R
Q
T
V
T
S
T
P
C
W
I
E
L
H
Site 41
T412
Q
W
L
D
K
V
L
T
Q
M
G
S
P
S
I
Site 42
S416
K
V
L
T
Q
M
G
S
P
S
I
R
C
S
S
Site 43
S418
L
T
Q
M
G
S
P
S
I
R
C
S
S
V
S
Site 44
S422
G
S
P
S
I
R
C
S
S
V
S
_
_
_
_
Site 45
S423
S
P
S
I
R
C
S
S
V
S
_
_
_
_
_
Site 46
S425
S
I
R
C
S
S
V
S
_
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation