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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
Shc2
Full Name:
SHC-transforming protein 2
Alias:
Sck; SH2 domain protein C2; SHCB; Src homology 2 domain-containing transforming protein C2
Type:
Adaptor/scaffold protein
Mass (Da):
61916
Number AA:
582
UniProt ID:
P98077
International Prot ID:
IPI00786975
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0007265
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T24
P
E
P
E
A
P
T
T
F
C
A
L
L
P
R
Site 2
S57
A
A
R
A
A
G
A
S
G
G
A
D
P
Q
P
Site 3
S97
P
C
P
L
P
A
L
S
R
C
R
G
A
G
S
Site 4
S104
S
R
C
R
G
A
G
S
R
G
S
R
G
G
R
Site 5
S107
R
G
A
G
S
R
G
S
R
G
G
R
G
A
A
Site 6
S130
A
E
W
I
R
K
G
S
F
I
H
K
P
A
H
Site 7
S166
G
C
I
E
V
L
R
S
M
R
S
L
D
F
N
Site 8
S169
E
V
L
R
S
M
R
S
L
D
F
N
T
R
T
Site 9
S196
A
V
P
G
V
R
G
S
W
K
K
K
A
P
N
Site 10
S232
H
I
S
T
D
G
L
S
L
S
V
P
A
T
R
Site 11
S234
S
T
D
G
L
S
L
S
V
P
A
T
R
Q
V
Site 12
S249
I
A
N
H
H
M
P
S
I
S
F
A
S
G
G
Site 13
S251
N
H
H
M
P
S
I
S
F
A
S
G
G
D
T
Site 14
T258
S
F
A
S
G
G
D
T
D
M
T
D
Y
V
A
Site 15
T261
S
G
G
D
T
D
M
T
D
Y
V
A
Y
V
A
Site 16
Y263
G
D
T
D
M
T
D
Y
V
A
Y
V
A
K
D
Site 17
Y266
D
M
T
D
Y
V
A
Y
V
A
K
D
P
I
N
Site 18
Y305
F
E
L
R
F
K
Q
Y
L
H
S
P
P
K
V
Site 19
S308
R
F
K
Q
Y
L
H
S
P
P
K
V
A
L
P
Site 20
S333
A
W
G
D
E
E
D
S
L
E
H
N
Y
Y
N
Site 21
Y338
E
D
S
L
E
H
N
Y
Y
N
S
I
P
G
K
Site 22
Y339
D
S
L
E
H
N
Y
Y
N
S
I
P
G
K
E
Site 23
S341
L
E
H
N
Y
Y
N
S
I
P
G
K
E
P
P
Site 24
S373
T
A
L
D
Q
G
P
S
P
S
L
R
D
A
C
Site 25
S375
L
D
Q
G
P
S
P
S
L
R
D
A
C
S
L
Site 26
S381
P
S
L
R
D
A
C
S
L
P
W
D
V
G
S
Site 27
S388
S
L
P
W
D
V
G
S
T
G
T
A
P
P
G
Site 28
T391
W
D
V
G
S
T
G
T
A
P
P
G
D
G
Y
Site 29
Y398
T
A
P
P
G
D
G
Y
V
Q
A
D
A
R
G
Site 30
Y414
P
D
H
E
E
H
L
Y
V
N
T
Q
G
L
D
Site 31
S428
D
A
P
E
P
E
D
S
P
K
K
D
L
F
D
Site 32
S467
P
L
E
D
Q
W
P
S
P
P
T
R
R
A
P
Site 33
Y488
Q
L
R
Q
E
P
W
Y
H
G
R
M
S
R
R
Site 34
S493
P
W
Y
H
G
R
M
S
R
R
A
A
E
R
M
Site 35
S512
G
D
F
L
V
R
D
S
V
T
N
P
G
Q
Y
Site 36
Y519
S
V
T
N
P
G
Q
Y
V
L
T
G
M
H
A
Site 37
S550
T
K
D
V
L
F
E
S
I
S
H
L
I
D
H
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation