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Updated November 2019
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Protein Info
Short Name:
HSPG2
Full Name:
Basement membrane-specific heparan sulfate proteoglycan core protein
Alias:
Heparan sulfate proteoglycan 2; HSPG; Perlecan; Perlecan proteoglycan; PGBM; PLC; PRCAN; SJS1
Type:
Adhesion
Mass (Da):
468798
Number AA:
4391
UniProt ID:
P98160
International Prot ID:
IPI00024284
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0008022
PhosphoSite+
KinaseNET
Biological Process:
GO:0007155
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T23
H
G
R
L
L
A
V
T
H
G
L
R
A
Y
D
Site 2
Y29
V
T
H
G
L
R
A
Y
D
G
L
S
L
P
E
Site 3
T40
S
L
P
E
D
I
E
T
V
T
A
S
Q
M
R
Site 4
T49
T
A
S
Q
M
R
W
T
H
S
Y
L
S
D
D
Site 5
S51
S
Q
M
R
W
T
H
S
Y
L
S
D
D
E
D
Site 6
S54
R
W
T
H
S
Y
L
S
D
D
E
D
M
L
A
Site 7
S63
D
E
D
M
L
A
D
S
I
S
G
D
D
L
G
Site 8
S65
D
M
L
A
D
S
I
S
G
D
D
L
G
S
G
Site 9
S71
I
S
G
D
D
L
G
S
G
D
L
G
S
G
D
Site 10
S76
L
G
S
G
D
L
G
S
G
D
F
Q
M
V
Y
Site 11
S93
A
L
V
N
F
T
R
S
I
E
Y
S
P
Q
L
Site 12
S97
F
T
R
S
I
E
Y
S
P
Q
L
E
D
A
G
Site 13
S105
P
Q
L
E
D
A
G
S
R
E
F
R
E
V
S
Site 14
S112
S
R
E
F
R
E
V
S
E
A
V
V
D
T
L
Site 15
T118
V
S
E
A
V
V
D
T
L
E
S
E
Y
L
K
Site 16
S176
I
S
S
G
S
V
A
S
Y
V
T
S
P
Q
G
Site 17
Y177
S
S
G
S
V
A
S
Y
V
T
S
P
Q
G
F
Site 18
S180
S
V
A
S
Y
V
T
S
P
Q
G
F
Q
F
R
Site 19
T191
F
Q
F
R
R
L
G
T
V
P
Q
F
P
R
A
Site 20
S229
R
P
D
C
R
D
M
S
D
E
L
N
C
E
E
Site 21
S253
S
L
L
V
E
T
T
S
L
P
P
R
P
E
T
Site 22
T260
S
L
P
P
R
P
E
T
T
I
M
R
Q
P
P
Site 23
T261
L
P
P
R
P
E
T
T
I
M
R
Q
P
P
V
Site 24
T269
I
M
R
Q
P
P
V
T
H
A
P
Q
P
L
L
Site 25
S279
P
Q
P
L
L
P
G
S
V
R
P
L
P
C
G
Site 26
Y302
G
H
C
I
P
R
D
Y
L
C
D
G
Q
E
D
Site 27
S314
Q
E
D
C
E
D
G
S
D
E
L
D
C
G
P
Site 28
T354
D
F
D
C
E
D
R
T
D
E
A
N
C
P
T
Site 29
T361
T
D
E
A
N
C
P
T
K
R
P
E
E
V
C
Site 30
S392
S
F
H
C
D
E
E
S
D
C
P
D
R
S
D
Site 31
S398
E
S
D
C
P
D
R
S
D
E
F
G
C
M
P
Site 32
T410
C
M
P
P
Q
V
V
T
P
P
R
E
S
I
Q
Site 33
S415
V
V
T
P
P
R
E
S
I
Q
A
S
R
G
Q
Site 34
S419
P
R
E
S
I
Q
A
S
R
G
Q
T
V
T
F
Site 35
T454
I
P
S
H
P
R
V
T
V
T
S
E
G
G
R
Site 36
S457
H
P
R
V
T
V
T
S
E
G
G
R
G
T
L
Site 37
T463
T
S
E
G
G
R
G
T
L
I
I
R
D
V
K
Site 38
S472
I
I
R
D
V
K
E
S
D
Q
G
A
Y
T
C
Site 39
Y511
P
C
P
D
G
H
F
Y
L
E
H
S
A
A
C
Site 40
S532
G
I
T
S
V
C
Q
S
T
R
R
F
R
D
Q
Site 41
T563
T
M
P
A
Q
P
G
T
P
P
L
S
S
T
Q
Site 42
S567
Q
P
G
T
P
P
L
S
S
T
Q
L
Q
I
D
Site 43
S576
T
Q
L
Q
I
D
P
S
L
H
E
F
Q
L
V
Site 44
S586
E
F
Q
L
V
D
L
S
R
R
F
L
V
H
D
Site 45
S594
R
R
F
L
V
H
D
S
F
W
A
L
P
E
Q
Site 46
S609
F
L
G
N
K
V
D
S
Y
G
G
S
L
R
Y
Site 47
Y610
L
G
N
K
V
D
S
Y
G
G
S
L
R
Y
N
Site 48
S613
K
V
D
S
Y
G
G
S
L
R
Y
N
V
R
Y
Site 49
Y616
S
Y
G
G
S
L
R
Y
N
V
R
Y
E
L
A
Site 50
Y620
S
L
R
Y
N
V
R
Y
E
L
A
R
G
M
L
Site 51
S646
G
A
G
Y
R
L
L
S
R
G
H
T
P
T
Q
Site 52
T650
R
L
L
S
R
G
H
T
P
T
Q
P
G
A
L
Site 53
T652
L
S
R
G
H
T
P
T
Q
P
G
A
L
N
Q
Site 54
S673
E
E
H
W
V
H
E
S
G
R
P
V
Q
R
A
Site 55
T715
S
D
I
A
M
D
T
T
V
T
H
A
T
S
H
Site 56
T717
I
A
M
D
T
T
V
T
H
A
T
S
H
G
R
Site 57
S727
T
S
H
G
R
A
H
S
V
E
E
C
R
C
P
Site 58
Y737
E
C
R
C
P
I
G
Y
S
G
L
S
C
E
S
Site 59
S741
P
I
G
Y
S
G
L
S
C
E
S
C
D
A
H
Site 60
T750
E
S
C
D
A
H
F
T
R
V
P
G
G
P
Y
Site 61
Y757
T
R
V
P
G
G
P
Y
L
G
T
C
S
G
C
Site 62
Y777
A
S
S
C
D
P
V
Y
G
H
C
L
N
C
Q
Site 63
Y818
C
R
P
C
P
C
P
Y
I
D
A
S
R
R
F
Site 64
S826
I
D
A
S
R
R
F
S
D
T
C
F
L
D
T
Site 65
T828
A
S
R
R
F
S
D
T
C
F
L
D
T
D
G
Site 66
Y846
C
D
A
C
A
P
G
Y
T
G
R
R
C
E
S
Site 67
T847
D
A
C
A
P
G
Y
T
G
R
R
C
E
S
C
Site 68
S853
Y
T
G
R
R
C
E
S
C
A
P
G
Y
E
G
Site 69
Y858
C
E
S
C
A
P
G
Y
E
G
N
P
I
Q
P
Site 70
S884
V
R
C
D
E
R
G
S
M
G
T
S
G
E
A
Site 71
T887
D
E
R
G
S
M
G
T
S
G
E
A
C
R
C
Site 72
S888
E
R
G
S
M
G
T
S
G
E
A
C
R
C
K
Site 73
S914
A
D
G
S
F
H
L
S
T
R
N
P
D
G
C
Site 74
T915
D
G
S
F
H
L
S
T
R
N
P
D
G
C
L
Site 75
T934
M
G
V
S
R
H
C
T
S
S
S
W
S
R
A
Site 76
S935
G
V
S
R
H
C
T
S
S
S
W
S
R
A
Q
Site 77
S936
V
S
R
H
C
T
S
S
S
W
S
R
A
Q
L
Site 78
S937
S
R
H
C
T
S
S
S
W
S
R
A
Q
L
H
Site 79
S939
H
C
T
S
S
S
W
S
R
A
Q
L
H
G
A
Site 80
S947
R
A
Q
L
H
G
A
S
E
E
P
G
H
F
S
Site 81
S954
S
E
E
P
G
H
F
S
L
T
N
A
A
S
T
Site 82
T956
E
P
G
H
F
S
L
T
N
A
A
S
T
H
T
Site 83
T964
N
A
A
S
T
H
T
T
N
E
G
I
F
S
P
Site 84
S970
T
T
N
E
G
I
F
S
P
T
P
G
E
L
G
Site 85
T972
N
E
G
I
F
S
P
T
P
G
E
L
G
F
S
Site 86
S979
T
P
G
E
L
G
F
S
S
F
H
R
L
L
S
Site 87
S980
P
G
E
L
G
F
S
S
F
H
R
L
L
S
G
Site 88
S986
S
S
F
H
R
L
L
S
G
P
Y
F
W
S
L
Site 89
Y989
H
R
L
L
S
G
P
Y
F
W
S
L
P
S
R
Site 90
T1003
R
F
L
G
D
K
V
T
S
Y
G
G
E
L
R
Site 91
Y1005
L
G
D
K
V
T
S
Y
G
G
E
L
R
F
T
Site 92
T1012
Y
G
G
E
L
R
F
T
V
T
Q
R
S
Q
P
Site 93
T1014
G
E
L
R
F
T
V
T
Q
R
S
Q
P
G
S
Site 94
S1017
R
F
T
V
T
Q
R
S
Q
P
G
S
T
P
L
Site 95
S1021
T
Q
R
S
Q
P
G
S
T
P
L
H
G
Q
P
Site 96
T1022
Q
R
S
Q
P
G
S
T
P
L
H
G
Q
P
L
Site 97
S1048
H
H
V
A
Q
E
P
S
P
G
Q
P
S
T
F
Site 98
S1053
E
P
S
P
G
Q
P
S
T
F
I
V
P
F
R
Site 99
T1054
P
S
P
G
Q
P
S
T
F
I
V
P
F
R
E
Site 100
T1073
R
P
D
G
Q
P
A
T
R
E
H
L
L
M
A
Site 101
S1092
D
T
L
L
I
R
A
S
Y
A
Q
Q
P
A
E
Site 102
Y1093
T
L
L
I
R
A
S
Y
A
Q
Q
P
A
E
S
Site 103
S1100
Y
A
Q
Q
P
A
E
S
R
V
S
G
I
S
M
Site 104
S1103
Q
P
A
E
S
R
V
S
G
I
S
M
D
V
A
Site 105
S1106
E
S
R
V
S
G
I
S
M
D
V
A
V
P
E
Site 106
S1127
A
L
E
V
E
Q
C
S
C
P
P
G
Y
R
G
Site 107
Y1132
Q
C
S
C
P
P
G
Y
R
G
P
S
C
Q
D
Site 108
S1136
P
P
G
Y
R
G
P
S
C
Q
D
C
D
T
G
Site 109
T1142
P
S
C
Q
D
C
D
T
G
Y
T
R
T
P
S
Site 110
Y1144
C
Q
D
C
D
T
G
Y
T
R
T
P
S
G
L
Site 111
T1145
Q
D
C
D
T
G
Y
T
R
T
P
S
G
L
Y
Site 112
T1147
C
D
T
G
Y
T
R
T
P
S
G
L
Y
L
G
Site 113
S1149
T
G
Y
T
R
T
P
S
G
L
Y
L
G
T
C
Site 114
T1155
P
S
G
L
Y
L
G
T
C
E
R
C
S
C
H
Site 115
T1172
S
E
A
C
E
P
E
T
G
A
C
Q
G
C
Q
Site 116
Y1194
C
E
Q
C
Q
P
G
Y
Y
G
D
A
Q
R
G
Site 117
T1202
Y
G
D
A
Q
R
G
T
P
Q
D
C
Q
L
C
Site 118
Y1212
D
C
Q
L
C
P
C
Y
G
D
P
A
A
G
Q
Site 119
S1238
H
P
T
C
D
A
C
S
P
G
H
S
G
R
H
Site 120
Y1253
C
E
R
C
A
P
G
Y
Y
G
N
P
S
Q
G
Site 121
Y1254
E
R
C
A
P
G
Y
Y
G
N
P
S
Q
G
Q
Site 122
S1258
P
G
Y
Y
G
N
P
S
Q
G
Q
P
C
Q
R
Site 123
S1267
G
Q
P
C
Q
R
D
S
Q
V
P
G
P
I
G
Site 124
S1282
C
N
C
D
P
Q
G
S
V
S
S
Q
C
D
A
Site 125
S1285
D
P
Q
G
S
V
S
S
Q
C
D
A
A
G
Q
Site 126
S1315
R
P
H
H
F
H
L
S
A
S
N
P
D
G
C
Site 127
S1317
H
H
F
H
L
S
A
S
N
P
D
G
C
L
P
Site 128
S1336
G
I
T
Q
Q
C
A
S
S
A
Y
T
R
H
L
Site 129
T1340
Q
C
A
S
S
A
Y
T
R
H
L
I
S
T
H
Site 130
S1345
A
Y
T
R
H
L
I
S
T
H
F
A
P
G
D
Site 131
T1346
Y
T
R
H
L
I
S
T
H
F
A
P
G
D
F
Site 132
S1365
L
V
N
P
Q
R
N
S
R
L
T
G
E
F
T
Site 133
T1368
P
Q
R
N
S
R
L
T
G
E
F
T
V
E
P
Site 134
T1372
S
R
L
T
G
E
F
T
V
E
P
V
P
E
G
Site 135
Y1411
Q
G
D
K
V
A
A
Y
G
G
K
L
R
Y
T
Site 136
T1418
Y
G
G
K
L
R
Y
T
L
S
Y
T
A
G
P
Site 137
S1420
G
K
L
R
Y
T
L
S
Y
T
A
G
P
Q
G
Site 138
Y1421
K
L
R
Y
T
L
S
Y
T
A
G
P
Q
G
S
Site 139
T1422
L
R
Y
T
L
S
Y
T
A
G
P
Q
G
S
P
Site 140
S1428
Y
T
A
G
P
Q
G
S
P
L
S
D
P
D
V
Site 141
S1431
G
P
Q
G
S
P
L
S
D
P
D
V
Q
I
T
Site 142
S1458
L
Q
G
P
E
R
R
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G
R
S
P
G
P
N
Site 446
S4319
E
E
L
V
S
G
R
S
P
G
P
N
V
A
V
Site 447
T4342
G
G
A
P
D
V
A
T
L
T
G
G
R
F
S
Site 448
T4344
A
P
D
V
A
T
L
T
G
G
R
F
S
S
G
Site 449
S4363
V
K
N
L
V
L
H
S
A
R
P
G
A
P
P
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation