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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
XIAP
Full Name:
Baculoviral IAP repeat-containing protein 4
Alias:
API3; BIR4; BIRC4; E3 ubiquitin-protein ligase XIAP; HILP; IAP3; IAP-like protein; Inhibitor of apoptosis protein 3; X-linked IAP; X-linked inhibitor of apoptosis; X-linked inhibitor of apoptosis protein
Type:
Inhibitor protein; Apoptosis; EC 6.3.2.-; Ligase
Mass (Da):
56685
Number AA:
497
UniProt ID:
P98170
International Prot ID:
IPI00303890
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
GO:0005737
GO:0005829
Uniprot
OncoNet
Molecular Function:
GO:0043027
GO:0016874
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0006916
GO:0006915
GO:0019941
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S9
T
F
N
S
F
E
G
S
K
T
C
V
P
A
D
Site 2
T11
N
S
F
E
G
S
K
T
C
V
P
A
D
I
N
Site 3
T32
E
E
F
N
R
L
K
T
F
A
N
F
P
S
G
Site 4
S38
K
T
F
A
N
F
P
S
G
S
P
V
S
A
S
Site 5
S40
F
A
N
F
P
S
G
S
P
V
S
A
S
T
L
Site 6
S45
S
G
S
P
V
S
A
S
T
L
A
R
A
G
F
Site 7
T46
G
S
P
V
S
A
S
T
L
A
R
A
G
F
L
Site 8
Y75
A
A
V
D
R
W
Q
Y
G
D
S
A
V
G
R
Site 9
S78
D
R
W
Q
Y
G
D
S
A
V
G
R
H
R
K
Site 10
S87
V
G
R
H
R
K
V
S
P
N
C
R
F
I
N
Site 11
Y97
C
R
F
I
N
G
F
Y
L
E
N
S
A
T
Q
Site 12
S101
N
G
F
Y
L
E
N
S
A
T
Q
S
T
N
S
Site 13
T103
F
Y
L
E
N
S
A
T
Q
S
T
N
S
G
I
Site 14
S105
L
E
N
S
A
T
Q
S
T
N
S
G
I
Q
N
Site 15
S108
S
A
T
Q
S
T
N
S
G
I
Q
N
G
Q
Y
Site 16
Y115
S
G
I
Q
N
G
Q
Y
K
V
E
N
Y
L
G
Site 17
Y120
G
Q
Y
K
V
E
N
Y
L
G
S
R
D
H
F
Site 18
S123
K
V
E
N
Y
L
G
S
R
D
H
F
A
L
D
Site 19
S133
H
F
A
L
D
R
P
S
E
T
H
A
D
Y
L
Site 20
Y139
P
S
E
T
H
A
D
Y
L
L
R
T
G
Q
V
Site 21
S150
T
G
Q
V
V
D
I
S
D
T
I
Y
P
R
N
Site 22
T152
Q
V
V
D
I
S
D
T
I
Y
P
R
N
P
A
Site 23
Y154
V
D
I
S
D
T
I
Y
P
R
N
P
A
M
Y
Site 24
Y161
Y
P
R
N
P
A
M
Y
S
E
E
A
R
L
K
Site 25
S162
P
R
N
P
A
M
Y
S
E
E
A
R
L
K
S
Site 26
S169
S
E
E
A
R
L
K
S
F
Q
N
W
P
D
Y
Site 27
Y176
S
F
Q
N
W
P
D
Y
A
H
L
T
P
R
E
Site 28
T180
W
P
D
Y
A
H
L
T
P
R
E
L
A
S
A
Site 29
Y190
E
L
A
S
A
G
L
Y
Y
T
G
I
G
D
Q
Site 30
S239
G
R
N
L
N
I
R
S
E
S
D
A
V
S
S
Site 31
S241
N
L
N
I
R
S
E
S
D
A
V
S
S
D
R
Site 32
S245
R
S
E
S
D
A
V
S
S
D
R
N
F
P
N
Site 33
S246
S
E
S
D
A
V
S
S
D
R
N
F
P
N
S
Site 34
S253
S
D
R
N
F
P
N
S
T
N
L
P
R
N
P
Site 35
S261
T
N
L
P
R
N
P
S
M
A
D
Y
E
A
R
Site 36
Y265
R
N
P
S
M
A
D
Y
E
A
R
I
F
T
F
Site 37
T308
F
H
C
G
G
G
L
T
D
W
K
P
S
E
D
Site 38
Y329
K
W
Y
P
G
C
K
Y
L
L
E
Q
K
G
Q
Site 39
T345
Y
I
N
N
I
H
L
T
H
S
L
E
E
C
L
Site 40
S347
N
N
I
H
L
T
H
S
L
E
E
C
L
V
R
Site 41
T355
L
E
E
C
L
V
R
T
T
E
K
T
P
S
L
Site 42
T356
E
E
C
L
V
R
T
T
E
K
T
P
S
L
T
Site 43
T359
L
V
R
T
T
E
K
T
P
S
L
T
R
R
I
Site 44
S361
R
T
T
E
K
T
P
S
L
T
R
R
I
D
D
Site 45
T369
L
T
R
R
I
D
D
T
I
F
Q
N
P
M
V
Site 46
S385
E
A
I
R
M
G
F
S
F
K
D
I
K
K
I
Site 47
S400
M
E
E
K
I
Q
I
S
G
S
N
Y
K
S
L
Site 48
S402
E
K
I
Q
I
S
G
S
N
Y
K
S
L
E
V
Site 49
Y404
I
Q
I
S
G
S
N
Y
K
S
L
E
V
L
V
Site 50
S421
L
V
N
A
Q
K
D
S
M
Q
D
E
S
S
Q
Site 51
S426
K
D
S
M
Q
D
E
S
S
Q
T
S
L
Q
K
Site 52
S427
D
S
M
Q
D
E
S
S
Q
T
S
L
Q
K
E
Site 53
S430
Q
D
E
S
S
Q
T
S
L
Q
K
E
I
S
T
Site 54
S436
T
S
L
Q
K
E
I
S
T
E
E
Q
L
R
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation