KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
FGD1
Full Name:
FYVE, RhoGEF and PH domain-containing protein 1
Alias:
AAS; Faciogenital dysplasia 1; Faciogenital dysplasia 1 protein; FGDY; FYVE, RhoGEF and PH domain containing 1; FYVE, rhoGEF and PH domain containing 1 (faciogenital dysplasia); FYVE, rhoGEF and PH domain-containing 1; Rho/Rac GEF; Rho/rac guanine nucleotide exchange factor FGD1; Rho/Rac guanine nucleotide exchange factor FGD1; ZFYVE3; Zinc finger FYVE domain-containing 3; Zinc finger FYVE domain-containing protein 3
Type:
Guanine nucleotide exchange factor, misc.
Mass (Da):
106561
Number AA:
961
UniProt ID:
P98174
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005794
GO:0005856
GO:0005829
Uniprot
OncoNet
Molecular Function:
GO:0005089
GO:0031267
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0030036
GO:0006915
GO:0046847
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S13
A
P
G
G
A
G
P
S
E
P
E
H
P
A
T
Site 2
T20
S
E
P
E
H
P
A
T
N
P
P
G
A
A
P
Site 3
S33
A
P
P
A
C
A
D
S
D
P
G
A
S
E
P
Site 4
S48
G
L
L
A
R
R
G
S
G
S
A
L
G
G
P
Site 5
S50
L
A
R
R
G
S
G
S
A
L
G
G
P
L
D
Site 6
S64
D
P
Q
F
V
G
P
S
D
T
S
L
G
A
A
Site 7
S67
F
V
G
P
S
D
T
S
L
G
A
A
P
G
H
Site 8
S82
R
V
L
P
C
G
P
S
P
Q
H
H
R
A
L
Site 9
S92
H
H
R
A
L
R
F
S
Y
H
L
E
G
S
Q
Site 10
Y93
H
R
A
L
R
F
S
Y
H
L
E
G
S
Q
P
Site 11
S98
F
S
Y
H
L
E
G
S
Q
P
R
P
G
L
H
Site 12
S114
G
N
R
I
L
V
K
S
L
S
L
D
P
G
Q
Site 13
S116
R
I
L
V
K
S
L
S
L
D
P
G
Q
S
L
Site 14
S122
L
S
L
D
P
G
Q
S
L
E
P
H
P
E
G
Site 15
S135
E
G
P
Q
R
L
R
S
D
P
G
P
P
T
E
Site 16
T141
R
S
D
P
G
P
P
T
E
T
P
S
Q
R
P
Site 17
T143
D
P
G
P
P
T
E
T
P
S
Q
R
P
S
P
Site 18
S145
G
P
P
T
E
T
P
S
Q
R
P
S
P
L
K
Site 19
S149
E
T
P
S
Q
R
P
S
P
L
K
R
A
P
G
Site 20
S166
P
Q
V
P
P
K
P
S
Y
L
Q
M
P
R
M
Site 21
Y167
Q
V
P
P
K
P
S
Y
L
Q
M
P
R
M
P
Site 22
S185
E
P
I
P
P
P
P
S
R
P
L
P
A
D
P
Site 23
S205
L
A
P
R
A
E
A
S
P
S
S
A
A
V
S
Site 24
S207
P
R
A
E
A
S
P
S
S
A
A
V
S
S
L
Site 25
S208
R
A
E
A
S
P
S
S
A
A
V
S
S
L
I
Site 26
S212
S
P
S
S
A
A
V
S
S
L
I
E
K
F
E
Site 27
S213
P
S
S
A
A
V
S
S
L
I
E
K
F
E
R
Site 28
S227
R
E
P
V
I
V
A
S
D
R
P
V
P
G
P
Site 29
S235
D
R
P
V
P
G
P
S
P
G
P
P
E
P
V
Site 30
S249
V
M
L
P
Q
P
T
S
Q
P
P
V
P
Q
L
Site 31
S283
E
K
V
P
N
R
D
S
G
I
D
S
I
S
S
Site 32
S287
N
R
D
S
G
I
D
S
I
S
S
P
S
N
S
Site 33
S289
D
S
G
I
D
S
I
S
S
P
S
N
S
E
E
Site 34
S290
S
G
I
D
S
I
S
S
P
S
N
S
E
E
T
Site 35
S292
I
D
S
I
S
S
P
S
N
S
E
E
T
C
F
Site 36
S294
S
I
S
S
P
S
N
S
E
E
T
C
F
V
S
Site 37
S301
S
E
E
T
C
F
V
S
D
D
G
P
P
S
H
Site 38
S307
V
S
D
D
G
P
P
S
H
S
L
C
P
G
P
Site 39
S309
D
D
G
P
P
S
H
S
L
C
P
G
P
P
A
Site 40
S332
A
D
P
H
R
P
G
S
Q
E
V
D
S
D
L
Site 41
S337
P
G
S
Q
E
V
D
S
D
L
E
E
E
D
D
Site 42
S365
P
L
M
E
R
Q
E
S
V
E
L
T
V
Q
Q
Site 43
T369
R
Q
E
S
V
E
L
T
V
Q
Q
K
V
F
H
Site 44
T384
I
A
N
E
L
L
Q
T
E
K
A
Y
V
S
R
Site 45
S411
L
E
E
A
R
N
R
S
S
F
P
A
D
V
V
Site 46
S412
E
E
A
R
N
R
S
S
F
P
A
D
V
V
H
Site 47
Y450
R
M
E
E
W
D
R
Y
P
R
I
G
D
I
L
Site 48
Y470
F
L
K
M
Y
G
E
Y
V
K
N
F
D
R
A
Site 49
T483
R
A
V
E
L
V
N
T
W
T
E
R
S
T
Q
Site 50
T485
V
E
L
V
N
T
W
T
E
R
S
T
Q
F
K
Site 51
Y523
P
V
Q
R
I
P
R
Y
E
L
L
L
K
D
Y
Site 52
Y530
Y
E
L
L
L
K
D
Y
L
L
K
L
P
H
G
Site 53
S538
L
L
K
L
P
H
G
S
P
D
S
K
D
A
Q
Site 54
S541
L
P
H
G
S
P
D
S
K
D
A
Q
K
S
L
Site 55
S547
D
S
K
D
A
Q
K
S
L
E
L
I
A
T
A
Site 56
T553
K
S
L
E
L
I
A
T
A
A
E
H
S
N
A
Site 57
Y575
M
H
K
L
L
K
V
Y
E
L
L
G
G
E
E
Site 58
S586
G
G
E
E
D
I
V
S
P
T
K
E
L
I
K
Site 59
S601
E
G
H
I
L
K
L
S
A
K
N
G
T
T
Q
Site 60
Y611
N
G
T
T
Q
D
R
Y
L
I
L
F
N
D
R
Site 61
Y621
L
F
N
D
R
L
L
Y
C
V
P
R
L
R
L
Site 62
S634
R
L
L
G
Q
K
F
S
V
R
A
R
I
D
V
Site 63
S649
D
G
M
E
L
K
E
S
S
N
L
N
L
P
R
Site 64
S650
G
M
E
L
K
E
S
S
N
L
N
L
P
R
T
Site 65
T657
S
N
L
N
L
P
R
T
F
L
V
S
G
K
Q
Site 66
S661
L
P
R
T
F
L
V
S
G
K
Q
R
S
L
E
Site 67
S666
L
V
S
G
K
Q
R
S
L
E
L
Q
A
R
T
Site 68
T694
T
L
L
K
H
E
Q
T
L
E
T
F
K
L
L
Site 69
T697
K
H
E
Q
T
L
E
T
F
K
L
L
N
S
T
Site 70
S703
E
T
F
K
L
L
N
S
T
N
R
E
D
E
D
Site 71
T704
T
F
K
L
L
N
S
T
N
R
E
D
E
D
T
Site 72
T711
T
N
R
E
D
E
D
T
P
P
N
S
P
N
V
Site 73
S715
D
E
D
T
P
P
N
S
P
N
V
D
L
G
K
Site 74
T726
D
L
G
K
R
A
P
T
P
I
R
E
K
E
V
Site 75
Y773
E
F
R
A
R
L
V
Y
D
N
N
R
S
N
R
Site 76
S795
A
L
H
G
V
P
G
S
S
P
A
C
S
Q
H
Site 77
S796
L
H
G
V
P
G
S
S
P
A
C
S
Q
H
T
Site 78
S800
P
G
S
S
P
A
C
S
Q
H
T
P
Q
R
R
Site 79
T803
S
P
A
C
S
Q
H
T
P
Q
R
R
R
S
I
Site 80
S809
H
T
P
Q
R
R
R
S
I
L
E
K
Q
A
S
Site 81
S816
S
I
L
E
K
Q
A
S
V
A
A
E
N
S
V
Site 82
Y854
E
N
E
P
L
V
L
Y
I
Y
G
A
P
Q
D
Site 83
T893
R
R
H
V
F
K
I
T
Q
S
H
L
S
W
Y
Site 84
S898
K
I
T
Q
S
H
L
S
W
Y
F
S
P
E
T
Site 85
Y900
T
Q
S
H
L
S
W
Y
F
S
P
E
T
E
E
Site 86
S902
S
H
L
S
W
Y
F
S
P
E
T
E
E
L
Q
Site 87
T905
S
W
Y
F
S
P
E
T
E
E
L
Q
R
R
W
Site 88
T924
G
R
A
G
R
G
D
T
F
C
P
G
P
T
L
Site 89
S932
F
C
P
G
P
T
L
S
E
D
R
E
M
E
E
Site 90
S954
A
T
A
E
P
P
E
S
P
Q
T
R
D
K
T
Site 91
T957
E
P
P
E
S
P
Q
T
R
D
K
T
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation