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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CYP4F8
Full Name:
Cytochrome P450 4F8
Alias:
CYPIVF8
Type:
Mass (Da):
59995
Number AA:
520
UniProt ID:
P98187
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T68
L
G
H
L
G
L
V
T
P
T
E
E
G
L
R
Site 2
S109
C
H
P
D
I
V
R
S
V
I
N
T
S
D
A
Site 3
T113
I
V
R
S
V
I
N
T
S
D
A
I
T
D
K
Site 4
S114
V
R
S
V
I
N
T
S
D
A
I
T
D
K
D
Site 5
T118
I
N
T
S
D
A
I
T
D
K
D
I
V
F
Y
Site 6
T127
K
D
I
V
F
Y
K
T
L
K
P
W
L
G
D
Site 7
S139
L
G
D
G
L
L
L
S
V
G
D
K
W
R
H
Site 8
T152
R
H
H
R
R
L
L
T
P
A
F
H
F
N
I
Site 9
Y163
H
F
N
I
L
K
P
Y
I
K
I
F
S
K
S
Site 10
S186
Q
R
L
A
M
E
G
S
T
C
L
D
V
F
E
Site 11
S209
S
L
Q
K
C
I
F
S
F
D
S
N
C
Q
E
Site 12
S212
K
C
I
F
S
F
D
S
N
C
Q
E
K
P
S
Site 13
T223
E
K
P
S
E
Y
I
T
A
I
M
E
L
S
A
Site 14
Y242
R
N
N
Q
F
F
R
Y
K
D
F
L
Y
F
L
Site 15
Y247
F
R
Y
K
D
F
L
Y
F
L
T
P
C
G
R
Site 16
T250
K
D
F
L
Y
F
L
T
P
C
G
R
R
F
H
Site 17
T267
C
R
L
V
H
D
F
T
D
A
V
I
Q
E
R
Site 18
T277
V
I
Q
E
R
R
R
T
L
T
S
Q
G
V
D
Site 19
T279
Q
E
R
R
R
T
L
T
S
Q
G
V
D
D
F
Site 20
S280
E
R
R
R
T
L
T
S
Q
G
V
D
D
F
L
Site 21
T295
Q
A
K
A
K
S
K
T
L
D
F
I
D
V
L
Site 22
S305
F
I
D
V
L
L
L
S
E
D
K
N
G
K
E
Site 23
S314
D
K
N
G
K
E
L
S
D
E
D
I
R
A
E
Site 24
S335
G
G
H
D
T
T
A
S
G
L
S
W
V
L
Y
Site 25
Y342
S
G
L
S
W
V
L
Y
N
L
A
R
H
P
E
Site 26
Y350
N
L
A
R
H
P
E
Y
Q
E
R
C
R
Q
E
Site 27
S388
L
T
M
C
L
K
E
S
L
R
L
H
P
P
I
Site 28
T397
R
L
H
P
P
I
P
T
F
A
R
G
C
T
Q
Site 29
T403
P
T
F
A
R
G
C
T
Q
D
V
V
L
P
D
Site 30
S411
Q
D
V
V
L
P
D
S
R
V
I
P
K
G
N
Site 31
S454
P
E
N
A
Q
K
R
S
P
M
A
F
I
P
F
Site 32
T501
D
H
R
E
P
R
R
T
P
E
I
V
L
R
A
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation