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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ATP8B2
Full Name:
Probable phospholipid-transporting ATPase ID
Alias:
AT8B2; ATPase, Class I, type 8B, member 2; ATPID; EC 3.6.3.1; KIAA1137; Probable phospholipid-transporting ATPase ID
Type:
Membrane protein, integral; Transporter; EC 3.6.3.1; Hydrolase
Mass (Da):
137440
Number AA:
1209
UniProt ID:
P98198
International Prot ID:
IPI00396074
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0015662
GO:0000287
PhosphoSite+
KinaseNET
Biological Process:
GO:0006754
GO:0015914
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S19
A
R
A
Q
A
P
P
S
W
S
R
K
K
P
S
Site 2
S21
A
Q
A
P
P
S
W
S
R
K
K
P
S
W
G
Site 3
S26
S
W
S
R
K
K
P
S
W
G
T
E
E
E
R
Site 4
Y42
A
R
A
N
D
R
E
Y
N
E
K
F
Q
Y
A
Site 5
Y48
E
Y
N
E
K
F
Q
Y
A
S
N
C
I
K
T
Site 6
T117
I
T
A
V
K
D
A
T
D
D
Y
F
R
H
K
Site 7
Y120
V
K
D
A
T
D
D
Y
F
R
H
K
S
D
N
Site 8
S134
N
Q
V
N
N
R
Q
S
Q
V
L
I
N
G
I
Site 9
Y181
S
E
P
H
G
L
C
Y
I
E
T
A
E
L
D
Site 10
T184
H
G
L
C
Y
I
E
T
A
E
L
D
G
E
T
Site 11
S209
T
S
E
L
G
D
I
S
K
L
A
K
F
D
G
Site 12
T233
K
L
D
K
F
S
G
T
L
Y
W
K
E
N
K
Site 13
Y235
D
K
F
S
G
T
L
Y
W
K
E
N
K
F
P
Site 14
S244
K
E
N
K
F
P
L
S
N
Q
N
M
L
L
R
Site 15
T272
V
I
F
A
G
P
D
T
K
L
M
Q
N
S
G
Site 16
S278
D
T
K
L
M
Q
N
S
G
R
T
K
F
K
R
Site 17
S287
R
T
K
F
K
R
T
S
I
D
R
L
M
N
T
Site 18
Y374
V
I
R
L
G
H
S
Y
F
I
N
W
D
K
K
Site 19
T389
M
F
C
M
K
K
R
T
P
A
E
A
R
T
T
Site 20
T396
T
P
A
E
A
R
T
T
T
L
N
E
E
L
G
Site 21
T397
P
A
E
A
R
T
T
T
L
N
E
E
L
G
Q
Site 22
S410
G
Q
V
E
Y
I
F
S
D
K
T
G
T
L
T
Site 23
T413
E
Y
I
F
S
D
K
T
G
T
L
T
Q
N
I
Site 24
T417
S
D
K
T
G
T
L
T
Q
N
I
M
V
F
N
Site 25
S456
R
P
E
P
V
D
F
S
F
N
P
L
A
D
K
Site 26
T483
V
K
I
G
D
P
H
T
H
E
F
F
R
L
L
Site 27
T495
R
L
L
S
L
C
H
T
V
M
S
E
E
K
N
Site 28
S498
S
L
C
H
T
V
M
S
E
E
K
N
E
G
E
Site 29
Y507
E
K
N
E
G
E
L
Y
Y
K
A
Q
S
P
D
Site 30
Y508
K
N
E
G
E
L
Y
Y
K
A
Q
S
P
D
E
Site 31
S512
E
L
Y
Y
K
A
Q
S
P
D
E
G
A
L
V
Site 32
S531
N
F
G
F
V
F
R
S
R
T
P
K
T
I
T
Site 33
T533
G
F
V
F
R
S
R
T
P
K
T
I
T
V
H
Site 34
T536
F
R
S
R
T
P
K
T
I
T
V
H
E
M
G
Site 35
T538
S
R
T
P
K
T
I
T
V
H
E
M
G
T
A
Site 36
S564
N
N
I
R
K
R
M
S
V
I
V
R
N
P
E
Site 37
Y577
P
E
G
K
I
R
L
Y
C
K
G
A
D
T
I
Site 38
S592
L
L
D
R
L
H
H
S
T
Q
E
L
L
N
T
Site 39
T593
L
D
R
L
H
H
S
T
Q
E
L
L
N
T
T
Site 40
T599
S
T
Q
E
L
L
N
T
T
M
D
H
L
N
E
Site 41
Y607
T
M
D
H
L
N
E
Y
A
G
E
G
L
R
T
Site 42
T614
Y
A
G
E
G
L
R
T
L
V
L
A
Y
K
D
Site 43
Y626
Y
K
D
L
D
E
E
Y
Y
E
E
W
A
E
R
Site 44
Y627
K
D
L
D
E
E
Y
Y
E
E
W
A
E
R
R
Site 45
S638
A
E
R
R
L
Q
A
S
L
A
Q
D
S
R
E
Site 46
S643
Q
A
S
L
A
Q
D
S
R
E
D
R
L
A
S
Site 47
S650
S
R
E
D
R
L
A
S
I
Y
E
E
V
E
N
Site 48
Y652
E
D
R
L
A
S
I
Y
E
E
V
E
N
N
M
Site 49
Y705
E
T
A
V
N
I
G
Y
S
C
K
M
L
T
D
Site 50
S742
A
R
E
K
M
M
D
S
S
R
S
V
G
N
G
Site 51
S743
R
E
K
M
M
D
S
S
R
S
V
G
N
G
F
Site 52
S745
K
M
M
D
S
S
R
S
V
G
N
G
F
T
Y
Site 53
T751
R
S
V
G
N
G
F
T
Y
Q
D
K
L
S
S
Site 54
Y752
S
V
G
N
G
F
T
Y
Q
D
K
L
S
S
S
Site 55
S757
F
T
Y
Q
D
K
L
S
S
S
K
L
T
S
V
Site 56
S759
Y
Q
D
K
L
S
S
S
K
L
T
S
V
L
E
Site 57
S839
G
D
G
A
N
D
V
S
M
I
K
T
A
H
I
Site 58
T843
N
D
V
S
M
I
K
T
A
H
I
G
V
G
I
Site 59
Y864
Q
A
V
L
A
S
D
Y
S
F
S
Q
F
K
F
Site 60
S867
L
A
S
D
Y
S
F
S
Q
F
K
F
L
Q
R
Site 61
Y955
P
E
Q
R
S
M
E
Y
P
K
L
Y
E
P
G
Site 62
Y959
S
M
E
Y
P
K
L
Y
E
P
G
Q
L
N
L
Site 63
T999
Y
G
V
F
A
D
A
T
R
D
D
G
T
Q
L
Site 64
T1004
D
A
T
R
D
D
G
T
Q
L
A
D
Y
Q
S
Site 65
Y1009
D
G
T
Q
L
A
D
Y
Q
S
F
A
V
T
V
Site 66
Y1034
Q
I
G
L
D
T
G
Y
W
T
A
I
N
H
F
Site 67
S1115
L
N
L
K
P
D
L
S
D
T
V
R
Y
T
Q
Site 68
T1117
L
K
P
D
L
S
D
T
V
R
Y
T
Q
L
V
Site 69
T1121
L
S
D
T
V
R
Y
T
Q
L
V
R
K
K
Q
Site 70
T1141
C
M
R
R
V
G
R
T
G
S
R
R
S
G
Y
Site 71
S1143
R
R
V
G
R
T
G
S
R
R
S
G
Y
A
F
Site 72
S1146
G
R
T
G
S
R
R
S
G
Y
A
F
S
H
Q
Site 73
Y1148
T
G
S
R
R
S
G
Y
A
F
S
H
Q
E
G
Site 74
S1151
R
R
S
G
Y
A
F
S
H
Q
E
G
F
G
E
Site 75
S1162
G
F
G
E
L
I
M
S
G
K
N
M
R
L
S
Site 76
S1169
S
G
K
N
M
R
L
S
S
L
A
L
S
S
F
Site 77
S1170
G
K
N
M
R
L
S
S
L
A
L
S
S
F
T
Site 78
S1174
R
L
S
S
L
A
L
S
S
F
T
T
R
S
S
Site 79
S1175
L
S
S
L
A
L
S
S
F
T
T
R
S
S
S
Site 80
T1177
S
L
A
L
S
S
F
T
T
R
S
S
S
S
W
Site 81
T1178
L
A
L
S
S
F
T
T
R
S
S
S
S
W
I
Site 82
S1180
L
S
S
F
T
T
R
S
S
S
S
W
I
E
S
Site 83
S1181
S
S
F
T
T
R
S
S
S
S
W
I
E
S
L
Site 84
S1182
S
F
T
T
R
S
S
S
S
W
I
E
S
L
R
Site 85
S1183
F
T
T
R
S
S
S
S
W
I
E
S
L
R
R
Site 86
S1187
S
S
S
S
W
I
E
S
L
R
R
K
K
S
D
Site 87
S1193
E
S
L
R
R
K
K
S
D
S
A
S
S
P
S
Site 88
S1195
L
R
R
K
K
S
D
S
A
S
S
P
S
G
G
Site 89
S1197
R
K
K
S
D
S
A
S
S
P
S
G
G
A
D
Site 90
S1198
K
K
S
D
S
A
S
S
P
S
G
G
A
D
K
Site 91
S1200
S
D
S
A
S
S
P
S
G
G
A
D
K
P
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation