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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PCTAIRE2
Full Name:
Cell division protein kinase 17
Alias:
EC 2.7.11.22; KPT2; PCTAIRE protein kinase 2; PCTAIRE-motif protein kinase 2; PCTK2; Serine/threonine-protein kinase PCTAIRE-2
Type:
EC 2.7.11.22; Protein kinase, Ser/Thr (non-receptor);
CMGC
group; CDK family; TAIRE subfamily; CDK/TAIRE subfamily
Mass (Da):
59582
Number AA:
523
UniProt ID:
Q00537
International Prot ID:
IPI00376955
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0004693
PhosphoSite+
KinaseNET
Biological Process:
GO:0006468
GO:0000074
Phosida
TranscriptoNet
STRING
Kinexus Products
Cell division protein kinase 17; Protein-serine kinase PCTAIRE-2 pan-specific antibody AB-NK285-1#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NK285-1#Cell division protein kinase 17; Protein-serine kinase PCTAIRE-2 S180 phosphosite-specific antibody AB-PK756#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PK756#Cell division protein kinase 17 / Protein-serine kinase PCTAIRE-2 (G14-E32, human) peptide - Powder PE-01BEJ85#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01BEJ85
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S9
K
K
F
K
R
R
L
S
L
T
L
R
G
S
Q
Site 2
T11
F
K
R
R
L
S
L
T
L
R
G
S
Q
T
I
Site 3
S15
L
S
L
T
L
R
G
S
Q
T
I
D
E
S
L
Site 4
T17
L
T
L
R
G
S
Q
T
I
D
E
S
L
S
E
Site 5
S21
G
S
Q
T
I
D
E
S
L
S
E
L
A
E
Q
Site 6
S23
Q
T
I
D
E
S
L
S
E
L
A
E
Q
M
T
Site 7
T30
S
E
L
A
E
Q
M
T
I
E
E
N
S
S
K
Site 8
S36
M
T
I
E
E
N
S
S
K
D
N
E
P
I
V
Site 9
T50
V
K
N
G
R
P
P
T
S
H
S
M
H
S
F
Site 10
S51
K
N
G
R
P
P
T
S
H
S
M
H
S
F
L
Site 11
S53
G
R
P
P
T
S
H
S
M
H
S
F
L
H
Q
Site 12
S56
P
T
S
H
S
M
H
S
F
L
H
Q
Y
T
G
Site 13
S64
F
L
H
Q
Y
T
G
S
F
K
K
P
P
L
R
Site 14
S75
P
P
L
R
R
P
H
S
V
I
G
G
S
L
G
Site 15
S80
P
H
S
V
I
G
G
S
L
G
S
F
M
A
M
Site 16
S92
M
A
M
P
R
N
G
S
R
L
D
I
V
H
E
Site 17
S105
H
E
N
L
K
M
G
S
D
G
E
S
D
Q
A
Site 18
S109
K
M
G
S
D
G
E
S
D
Q
A
S
G
T
S
Site 19
S113
D
G
E
S
D
Q
A
S
G
T
S
S
D
E
V
Site 20
T115
E
S
D
Q
A
S
G
T
S
S
D
E
V
Q
S
Site 21
S116
S
D
Q
A
S
G
T
S
S
D
E
V
Q
S
P
Site 22
S117
D
Q
A
S
G
T
S
S
D
E
V
Q
S
P
T
Site 23
S122
T
S
S
D
E
V
Q
S
P
T
G
V
C
L
R
Site 24
T124
S
D
E
V
Q
S
P
T
G
V
C
L
R
N
R
Site 25
S137
N
R
I
H
R
R
I
S
M
E
D
L
N
K
R
Site 26
S146
E
D
L
N
K
R
L
S
L
P
A
D
I
R
I
Site 27
Y157
D
I
R
I
P
D
G
Y
L
E
K
L
Q
I
N
Site 28
S165
L
E
K
L
Q
I
N
S
P
P
F
D
Q
P
M
Site 29
S173
P
P
F
D
Q
P
M
S
R
R
S
R
R
A
S
Site 30
S176
D
Q
P
M
S
R
R
S
R
R
A
S
L
S
E
Site 31
S180
S
R
R
S
R
R
A
S
L
S
E
I
G
F
G
Cell division protein kinase 17; Protein-serine kinase PCTAIRE-2 S180 phosphosite-specific antibody AB-PK756#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PK756
Site 32
S182
R
S
R
R
A
S
L
S
E
I
G
F
G
K
M
Site 33
Y192
G
F
G
K
M
E
T
Y
I
K
L
E
K
L
G
Site 34
T202
L
E
K
L
G
E
G
T
Y
A
T
V
Y
K
G
Site 35
Y203
E
K
L
G
E
G
T
Y
A
T
V
Y
K
G
R
Site 36
T205
L
G
E
G
T
Y
A
T
V
Y
K
G
R
S
K
Site 37
Y207
E
G
T
Y
A
T
V
Y
K
G
R
S
K
L
T
Site 38
S240
C
T
A
I
R
E
V
S
L
L
K
D
L
K
H
Site 39
Y269
S
L
T
L
V
F
E
Y
L
D
K
D
L
K
Q
Site 40
Y277
L
D
K
D
L
K
Q
Y
M
D
D
C
G
N
I
Site 41
Y303
Q
I
L
R
G
L
A
Y
C
H
R
R
K
V
L
Site 42
S339
F
G
L
A
R
A
K
S
V
P
T
K
T
Y
S
Site 43
T344
A
K
S
V
P
T
K
T
Y
S
N
E
V
V
T
Site 44
S346
S
V
P
T
K
T
Y
S
N
E
V
V
T
L
W
Site 45
S363
P
P
D
V
L
L
G
S
S
E
Y
S
T
Q
I
Site 46
S367
L
L
G
S
S
E
Y
S
T
Q
I
D
M
W
G
Site 47
T368
L
G
S
S
E
Y
S
T
Q
I
D
M
W
G
V
Site 48
S392
G
R
P
L
F
P
G
S
T
V
E
D
E
L
H
Site 49
T393
R
P
L
F
P
G
S
T
V
E
D
E
L
H
L
Site 50
T407
L
I
F
R
L
L
G
T
P
S
Q
E
T
W
P
Site 51
S409
F
R
L
L
G
T
P
S
Q
E
T
W
P
G
I
Site 52
T412
L
G
T
P
S
Q
E
T
W
P
G
I
S
S
N
Site 53
S418
E
T
W
P
G
I
S
S
N
E
E
F
K
N
Y
Site 54
Y425
S
N
E
E
F
K
N
Y
N
F
P
K
Y
K
P
Site 55
Y430
K
N
Y
N
F
P
K
Y
K
P
Q
P
L
I
N
Site 56
S444
N
H
A
P
R
L
D
S
E
G
I
E
L
I
T
Site 57
S458
T
K
F
L
Q
Y
E
S
K
K
R
V
S
A
E
Site 58
S463
Y
E
S
K
K
R
V
S
A
E
E
A
M
K
H
Site 59
Y472
E
E
A
M
K
H
V
Y
F
R
S
L
G
P
R
Site 60
S475
M
K
H
V
Y
F
R
S
L
G
P
R
I
H
A
Site 61
S491
P
E
S
V
S
I
F
S
L
K
E
I
Q
L
Q
Site 62
S506
K
D
P
G
F
R
N
S
S
Y
P
E
T
G
H
Site 63
S507
D
P
G
F
R
N
S
S
Y
P
E
T
G
H
G
Site 64
Y508
P
G
F
R
N
S
S
Y
P
E
T
G
H
G
K
Site 65
T511
R
N
S
S
Y
P
E
T
G
H
G
K
N
R
R
Site 66
S520
H
G
K
N
R
R
Q
S
M
L
F
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation