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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
HSF1
Full Name:
Heat shock factor protein 1
Alias:
Heat shock factor protein 1: Heat shock transcription factor 1: Heat shock factor protein 1: Heat shock transcription factor 1; Heat shock transcription factor 1; HSTF1
Type:
Transcription protein
Mass (Da):
57260
Number AA:
529
UniProt ID:
Q00613
International Prot ID:
IPI00024071
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0003700
PhosphoSite+
KinaseNET
Biological Process:
GO:0006355
GO:0006350
Phosida
TranscriptoNet
STRING
Kinexus Products
Heat shock factor protein 1 pan-specific antibody AB-NN268-1#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NN268-1#Heat shock factor protein 1 pan-specific antibody AB-NN268-2#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NN268-2#Heat shock factor protein 1 pan-specific antibody AB-NN268-3#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NN268-3#Heat shock factor protein 1 pan-specific antibody AB-NN268-4#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NN268-4
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S27
T
K
L
W
T
L
V
S
D
P
D
T
D
A
L
Site 2
S38
T
D
A
L
I
C
W
S
P
S
G
N
S
F
H
Site 3
Y60
A
K
E
V
L
P
K
Y
F
K
H
N
N
M
A
Site 4
Y76
F
V
R
Q
L
N
M
Y
G
F
R
K
V
V
H
Site 5
T97
V
K
P
E
R
D
D
T
E
F
Q
H
P
C
F
Site 6
T120
E
N
I
K
R
K
V
T
S
V
S
T
L
K
S
Site 7
S121
N
I
K
R
K
V
T
S
V
S
T
L
K
S
E
Site 8
S123
K
R
K
V
T
S
V
S
T
L
K
S
E
D
I
Site 9
S127
T
S
V
S
T
L
K
S
E
D
I
K
I
R
Q
Site 10
S136
D
I
K
I
R
Q
D
S
V
T
K
L
L
T
D
Site 11
T138
K
I
R
Q
D
S
V
T
K
L
L
T
D
V
Q
Site 12
T142
D
S
V
T
K
L
L
T
D
V
Q
L
M
K
G
Site 13
S174
A
L
W
R
E
V
A
S
L
R
Q
K
H
A
Q
Site 14
S216
I
P
L
M
L
N
D
S
G
S
A
H
S
M
P
Site 15
S218
L
M
L
N
D
S
G
S
A
H
S
M
P
K
Y
Site 16
S221
N
D
S
G
S
A
H
S
M
P
K
Y
S
R
Q
Site 17
Y225
S
A
H
S
M
P
K
Y
S
R
Q
F
S
L
E
Site 18
S226
A
H
S
M
P
K
Y
S
R
Q
F
S
L
E
H
Site 19
S230
P
K
Y
S
R
Q
F
S
L
E
H
V
H
G
S
Site 20
S237
S
L
E
H
V
H
G
S
G
P
Y
S
A
P
S
Site 21
Y240
H
V
H
G
S
G
P
Y
S
A
P
S
P
A
Y
Site 22
S241
V
H
G
S
G
P
Y
S
A
P
S
P
A
Y
S
Site 23
S244
S
G
P
Y
S
A
P
S
P
A
Y
S
S
S
S
Site 24
Y247
Y
S
A
P
S
P
A
Y
S
S
S
S
L
Y
A
Site 25
S248
S
A
P
S
P
A
Y
S
S
S
S
L
Y
A
P
Site 26
S249
A
P
S
P
A
Y
S
S
S
S
L
Y
A
P
D
Site 27
S250
P
S
P
A
Y
S
S
S
S
L
Y
A
P
D
A
Site 28
S251
S
P
A
Y
S
S
S
S
L
Y
A
P
D
A
V
Site 29
Y253
A
Y
S
S
S
S
L
Y
A
P
D
A
V
A
S
Site 30
S275
I
T
E
L
A
P
A
S
P
M
A
S
P
G
G
Site 31
S279
A
P
A
S
P
M
A
S
P
G
G
S
I
D
E
Site 32
S283
P
M
A
S
P
G
G
S
I
D
E
R
P
L
S
Site 33
S290
S
I
D
E
R
P
L
S
S
S
P
L
V
R
V
Site 34
S292
D
E
R
P
L
S
S
S
P
L
V
R
V
K
E
Site 35
S303
R
V
K
E
E
P
P
S
P
P
Q
S
P
R
V
Site 36
S307
E
P
P
S
P
P
Q
S
P
R
V
E
E
A
S
Site 37
S314
S
P
R
V
E
E
A
S
P
G
R
P
S
S
V
Site 38
S319
E
A
S
P
G
R
P
S
S
V
D
T
L
L
S
Site 39
S320
A
S
P
G
R
P
S
S
V
D
T
L
L
S
P
Site 40
T323
G
R
P
S
S
V
D
T
L
L
S
P
T
A
L
Site 41
S326
S
S
V
D
T
L
L
S
P
T
A
L
I
D
S
Site 42
T328
V
D
T
L
L
S
P
T
A
L
I
D
S
I
L
Site 43
S333
S
P
T
A
L
I
D
S
I
L
R
E
S
E
P
Site 44
S338
I
D
S
I
L
R
E
S
E
P
A
P
A
S
V
Site 45
S344
E
S
E
P
A
P
A
S
V
T
A
L
T
D
A
Site 46
T349
P
A
S
V
T
A
L
T
D
A
R
G
H
T
D
Site 47
T355
L
T
D
A
R
G
H
T
D
T
E
G
R
P
P
Site 48
T357
D
A
R
G
H
T
D
T
E
G
R
P
P
S
P
Site 49
S363
D
T
E
G
R
P
P
S
P
P
P
T
S
T
P
Site 50
T367
R
P
P
S
P
P
P
T
S
T
P
E
K
C
L
Site 51
S368
P
P
S
P
P
P
T
S
T
P
E
K
C
L
S
Site 52
T369
P
S
P
P
P
T
S
T
P
E
K
C
L
S
V
Site 53
S375
S
T
P
E
K
C
L
S
V
A
C
L
D
K
N
Site 54
S385
C
L
D
K
N
E
L
S
D
H
L
D
A
M
D
Site 55
S393
D
H
L
D
A
M
D
S
N
L
D
N
L
Q
T
Site 56
T400
S
N
L
D
N
L
Q
T
M
L
S
S
H
G
F
Site 57
S403
D
N
L
Q
T
M
L
S
S
H
G
F
S
V
D
Site 58
S404
N
L
Q
T
M
L
S
S
H
G
F
S
V
D
T
Site 59
S419
S
A
L
L
D
L
F
S
P
S
V
T
V
P
D
Site 60
S428
S
V
T
V
P
D
M
S
L
P
D
L
D
S
S
Site 61
S434
M
S
L
P
D
L
D
S
S
L
A
S
I
Q
E
Site 62
S435
S
L
P
D
L
D
S
S
L
A
S
I
Q
E
L
Site 63
S438
D
L
D
S
S
L
A
S
I
Q
E
L
L
S
P
Site 64
S444
A
S
I
Q
E
L
L
S
P
Q
E
P
P
R
P
Site 65
S457
R
P
P
E
A
E
N
S
S
P
D
S
G
K
Q
Site 66
S458
P
P
E
A
E
N
S
S
P
D
S
G
K
Q
L
Site 67
S461
A
E
N
S
S
P
D
S
G
K
Q
L
V
H
Y
Site 68
Y468
S
G
K
Q
L
V
H
Y
T
A
Q
P
L
F
L
Site 69
S480
L
F
L
L
D
P
G
S
V
D
T
G
S
N
D
Site 70
S485
P
G
S
V
D
T
G
S
N
D
L
P
V
L
F
Site 71
S498
L
F
E
L
G
E
G
S
Y
F
S
E
G
D
G
Site 72
Y499
F
E
L
G
E
G
S
Y
F
S
E
G
D
G
F
Site 73
S501
L
G
E
G
S
Y
F
S
E
G
D
G
F
A
E
Site 74
T511
D
G
F
A
E
D
P
T
I
S
L
L
T
G
S
Site 75
S518
T
I
S
L
L
T
G
S
E
P
P
K
A
K
D
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation