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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MYBPC1
Full Name:
Myosin-binding protein C, slow-type
Alias:
C-protein, skeletal muscle slow-isoform; MYBPCS; Myosin binding protein C, slow type; MYPC1; Slow MyBP-C
Type:
Actin binding protein; Myosin binding protein
Mass (Da):
128294
Number AA:
1141
UniProt ID:
Q00872
International Prot ID:
IPI00025092
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0030016
GO:0032982
Uniprot
OncoNet
Molecular Function:
GO:0003779
GO:0008307
GO:0031432
PhosphoSite+
KinaseNET
Biological Process:
GO:0007155
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T31
K
E
K
E
A
G
T
T
P
A
K
D
W
T
L
Site 2
T37
T
T
P
A
K
D
W
T
L
V
E
T
P
P
G
Site 3
T41
K
D
W
T
L
V
E
T
P
P
G
E
E
Q
A
Site 4
S54
Q
A
K
Q
N
A
N
S
Q
L
S
I
L
F
I
Site 5
T91
E
D
L
L
R
K
P
T
I
K
W
F
K
G
K
Site 6
S104
G
K
W
M
D
L
A
S
K
A
G
K
H
L
Q
Site 7
T115
K
H
L
Q
L
K
E
T
F
E
R
H
S
R
V
Site 8
S120
K
E
T
F
E
R
H
S
R
V
Y
T
F
E
M
Site 9
Y123
F
E
R
H
S
R
V
Y
T
F
E
M
Q
I
I
Site 10
T124
E
R
H
S
R
V
Y
T
F
E
M
Q
I
I
K
Site 11
Y140
K
D
N
F
A
G
N
Y
R
C
E
V
T
Y
K
Site 12
Y146
N
Y
R
C
E
V
T
Y
K
D
K
F
D
S
C
Site 13
S152
T
Y
K
D
K
F
D
S
C
S
F
D
L
E
V
Site 14
S154
K
D
K
F
D
S
C
S
F
D
L
E
V
H
E
Site 15
S162
F
D
L
E
V
H
E
S
T
G
T
T
P
N
I
Site 16
T165
E
V
H
E
S
T
G
T
T
P
N
I
D
I
R
Site 17
T166
V
H
E
S
T
G
T
T
P
N
I
D
I
R
S
Site 18
S173
T
P
N
I
D
I
R
S
A
F
K
R
S
G
E
Site 19
S191
D
A
G
E
L
D
F
S
G
L
L
K
R
R
E
Site 20
S251
M
R
R
E
E
K
K
S
A
A
F
A
K
I
L
Site 21
Y262
A
K
I
L
D
P
A
Y
Q
V
D
K
G
G
R
Site 22
Y286
P
K
L
E
V
K
W
Y
K
N
G
Q
E
I
R
Site 23
S295
N
G
Q
E
I
R
P
S
T
K
Y
I
F
E
H
Site 24
T296
G
Q
E
I
R
P
S
T
K
Y
I
F
E
H
K
Site 25
Y298
E
I
R
P
S
T
K
Y
I
F
E
H
K
G
C
Site 26
Y322
Q
M
T
D
D
S
E
Y
Y
V
T
A
G
D
E
Site 27
Y323
M
T
D
D
S
E
Y
Y
V
T
A
G
D
E
K
Site 28
T325
D
D
S
E
Y
Y
V
T
A
G
D
E
K
C
S
Site 29
T333
A
G
D
E
K
C
S
T
E
L
F
V
R
E
P
Site 30
T351
V
T
K
Q
L
E
D
T
T
A
Y
C
G
E
R
Site 31
T352
T
K
Q
L
E
D
T
T
A
Y
C
G
E
R
V
Site 32
Y354
Q
L
E
D
T
T
A
Y
C
G
E
R
V
E
L
Site 33
S366
V
E
L
E
C
E
V
S
E
D
D
A
N
V
K
Site 34
S387
E
I
I
P
G
P
K
S
R
Y
R
I
R
V
E
Site 35
S414
K
A
D
A
A
E
Y
S
V
M
T
T
G
G
Q
Site 36
T417
A
A
E
Y
S
V
M
T
T
G
G
Q
S
S
A
Site 37
T418
A
E
Y
S
V
M
T
T
G
G
Q
S
S
A
K
Site 38
S422
V
M
T
T
G
G
Q
S
S
A
K
L
S
V
D
Site 39
S423
M
T
T
G
G
Q
S
S
A
K
L
S
V
D
L
Site 40
S427
G
Q
S
S
A
K
L
S
V
D
L
K
P
L
K
Site 41
T437
L
K
P
L
K
I
L
T
P
L
T
D
Q
T
V
Site 42
T443
L
T
P
L
T
D
Q
T
V
N
L
G
K
E
I
Site 43
S474
N
G
L
P
V
Q
E
S
D
R
L
K
V
V
H
Site 44
Y501
L
T
E
D
E
G
D
Y
V
F
A
P
D
A
Y
Site 45
S550
L
R
L
E
I
P
I
S
G
E
P
P
P
K
A
Site 46
S560
P
P
P
K
A
M
W
S
R
G
D
K
A
I
M
Site 47
S570
D
K
A
I
M
E
G
S
G
R
I
R
T
E
S
Site 48
T575
E
G
S
G
R
I
R
T
E
S
Y
P
D
S
S
Site 49
S577
S
G
R
I
R
T
E
S
Y
P
D
S
S
T
L
Site 50
Y578
G
R
I
R
T
E
S
Y
P
D
S
S
T
L
V
Site 51
S581
R
T
E
S
Y
P
D
S
S
T
L
V
I
D
I
Site 52
S582
T
E
S
Y
P
D
S
S
T
L
V
I
D
I
A
Site 53
T583
E
S
Y
P
D
S
S
T
L
V
I
D
I
A
E
Site 54
S594
D
I
A
E
R
D
D
S
G
V
Y
H
I
N
L
Site 55
S611
E
A
G
E
A
H
A
S
I
K
V
K
V
V
D
Site 56
T627
P
D
P
P
V
A
P
T
V
T
E
V
G
D
D
Site 57
Y645
M
N
W
E
P
P
A
Y
D
G
G
S
P
I
L
Site 58
Y654
G
G
S
P
I
L
G
Y
F
I
E
R
K
K
K
Site 59
S663
I
E
R
K
K
K
Q
S
S
R
W
M
R
L
N
Site 60
S664
E
R
K
K
K
Q
S
S
R
W
M
R
L
N
F
Site 61
T678
F
D
L
C
K
E
T
T
F
E
P
K
K
M
I
Site 62
S703
A
V
N
A
I
G
I
S
K
P
S
M
P
S
R
Site 63
S706
A
I
G
I
S
K
P
S
M
P
S
R
P
F
V
Site 64
S709
I
S
K
P
S
M
P
S
R
P
F
V
P
L
A
Site 65
T725
T
S
P
P
T
L
L
T
V
D
S
V
T
D
T
Site 66
T732
T
V
D
S
V
T
D
T
T
V
T
M
R
W
R
Site 67
T733
V
D
S
V
T
D
T
T
V
T
M
R
W
R
P
Site 68
T735
S
V
T
D
T
T
V
T
M
R
W
R
P
P
D
Site 69
Y756
L
D
G
Y
V
L
E
Y
C
F
E
G
S
T
S
Site 70
S763
Y
C
F
E
G
S
T
S
A
K
Q
S
D
E
N
Site 71
S767
G
S
T
S
A
K
Q
S
D
E
N
G
E
A
A
Site 72
Y775
D
E
N
G
E
A
A
Y
D
L
P
A
E
D
W
Site 73
T793
N
K
D
L
I
D
K
T
K
F
T
I
T
G
L
Site 74
Y823
A
G
A
S
E
P
K
Y
Y
S
Q
P
I
L
V
Site 75
Y824
G
A
S
E
P
K
Y
Y
S
Q
P
I
L
V
K
Site 76
S825
A
S
E
P
K
Y
Y
S
Q
P
I
L
V
K
E
Site 77
T848
I
P
R
H
L
K
Q
T
Y
I
R
R
V
G
E
Site 78
Y849
P
R
H
L
K
Q
T
Y
I
R
R
V
G
E
A
Site 79
T894
I
R
N
S
E
T
D
T
I
I
F
I
R
K
A
Site 80
S904
F
I
R
K
A
E
R
S
H
S
G
K
Y
D
L
Site 81
S906
R
K
A
E
R
S
H
S
G
K
Y
D
L
Q
V
Site 82
T921
K
V
D
K
F
V
E
T
A
S
I
D
I
Q
I
Site 83
S923
D
K
F
V
E
T
A
S
I
D
I
Q
I
I
D
Site 84
T951
W
G
E
N
V
A
L
T
W
T
P
P
K
D
D
Site 85
T953
E
N
V
A
L
T
W
T
P
P
K
D
D
G
N
Site 86
Y985
W
F
T
V
I
E
H
Y
H
R
T
S
A
T
I
Site 87
S989
I
E
H
Y
H
R
T
S
A
T
I
T
E
L
V
Site 88
T993
H
R
T
S
A
T
I
T
E
L
V
I
G
N
E
Site 89
Y1001
E
L
V
I
G
N
E
Y
Y
F
R
V
F
S
E
Site 90
Y1002
L
V
I
G
N
E
Y
Y
F
R
V
F
S
E
N
Site 91
T1018
C
G
L
S
E
D
A
T
M
T
K
E
S
A
V
Site 92
Y1033
I
A
R
D
G
K
I
Y
K
N
P
V
Y
E
D
Site 93
Y1038
K
I
Y
K
N
P
V
Y
E
D
F
D
F
S
E
Site 94
S1069
Y
N
A
T
L
N
C
S
V
R
G
N
P
K
P
Site 95
Y1093
A
I
V
D
D
P
R
Y
R
M
F
S
N
Q
G
Site 96
S1097
D
P
R
Y
R
M
F
S
N
Q
G
V
C
T
L
Site 97
S1110
T
L
E
I
R
K
P
S
P
Y
D
G
G
T
Y
Site 98
Y1112
E
I
R
K
P
S
P
Y
D
G
G
T
Y
C
C
Site 99
Y1117
S
P
Y
D
G
G
T
Y
C
C
K
A
V
N
D
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation